Compare Relpax vs. Onzetra

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relpax
(eletriptan)

Onzetra
(sumatriptan)

Treats migraine headaches. Relpax (eletriptan) is a first choice medicine to treat migraines, but it can be expensive.Treats migraine headaches. Onzetra (sumatriptan) is the only medicine that's available in a breath-powered nose powder to treat migraines. However, it can be expensive compared to other medicines.
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Reviews & ratings
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Have you used Relpax (eletriptan)?
Worth itNot sureNot worth it

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Have you used Onzetra (sumatriptan)?
Worth itNot sureNot worth it
Side effects
RelpaxOnzetra
  • Headache 1%
  • Weakness 1%
  • Tingling or prickling sensation 1%
  • Indigestion 1%
  • Abdominal issues 1%
More Relpax side effects »
  • Changes in taste 17%
  • Discomfort in the nose 10%
  • Runny nose 3%
  • Stuffy nose 2%
More Onzetra side effects »
How it works
RelpaxOnzetra
Relpax (eletriptan) is a triptan. Migraine headaches happen when blood vessels are too open and allow too much blood to the brain. Relpax (eletriptan) tightens the blood vessels, which relieves the pain.Onzetra (sumatriptan) is a selective serotonin receptor agonist called a triptan. It's believed that migraine headaches happen when blood vessels are too open and allow too much blood in the brain. Onzetra (sumatriptan) tightens the blood vessels, which relieves the pain.
Type of medication
RelpaxOnzetra
Prescription only
Prescription only
Available as
RelpaxOnzetra
  • Pill
  • Nasal powder
Used for
RelpaxOnzetra
Risk factors for serious side effects
RelpaxOnzetra
  • Heart rhythm problems
  • History of chest pain
  • Uncontrolled high blood pressure
  • History of a stroke
  • Using Relpax (eletriptan) for more than 10 days a month
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
  • ADHD medicines
  • Triptans
  • Uncontrolled high blood pressure
  • High blood pressure
  • History of stroke
  • History of heart attack
Detailed Relpax (eletriptan) risks & warnings »
  • Heart disease
  • History of chest pain
  • Uncontrolled high blood pressure
  • History of a stroke
  • Using Onzetra (sumatriptan) for more than 10 days a month
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
  • ADHD medicines
  • Triptans
  • Uncontrolled high blood pressure
  • Taking medicines for seizures
  • High blood pressure
  • History of stroke
Detailed Onzetra (sumatriptan) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Upsides and benefits
RelpaxOnzetra
  • Relpax (eletriptan) works as well as other first choice medicines for migraines.
  • Relpax (eletriptan) comes in 2 different strengths.
  • Compared to pills, Onzetra (sumatriptan) is better absorbed in the body and good if it's hard to take pills.
  • Onzetra (sumatriptan) is a first choice medicine to treat migraines.
  • There is a copay program available that can make Onzetra (sumatriptan) cheaper.
Downsides and risks
RelpaxOnzetra
  • Relpax (eletriptan) is only available as a brand name.
  • Relpax (eletriptan) can cause dizziness and might make you more likely to fall.
  • If you have more than 3 migraines a month, Relpax (eletriptan) isn't a good choice because of its side effects.
  • It can be very expensive. There are other forms of this same medicine that are much cheaper, including a nose spray.
  • You have to use two nosepieces to get the full dose of Onzetra (sumatriptan), which can be hard to remember.
  • Onzetra (sumatriptan) is only available in one strength.
Tips from our pharmacists for people taking the medication
RelpaxOnzetra
  • Relpax (eletriptan) can only treat a migraine that's already happening. Relpax (eletriptan) doesn't prevent migraines from starting.
  • Take Relpax (eletriptan) at the first sign of a migraine. You can take another dose if you don't feel better after 2 hours. Don't take more than 80 mg every 24 hours.
  • Relpax (eletriptan) can make you feel dizzy or tired when you first start taking it. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • If you find you're using the entire month's supply of Relpax (eletriptan) before your next refill, talk to your doctor to see if you should try something else.
  • Relpax (eletriptan) can cause nausea or tightness in the chest or throat. Talk to your doctor if it bothers you.
  • Follow the instructions exactly as shown by the package insert and your doctor or pharmacist; otherwise, Onzetra (sumatriptan) won't work correctly and you won't get any medicine.
  • Onzetra (sumatriptan) can only treat a migraine that's already happening. You can't use it to stop migraines from starting.
  • You have to use 2 nosepieces of Onzetra (sumatriptan) to get the full dose of medicine.
  • Don't use more than 2 full doses (4 nosepieces) in a 24-hour period.
  • If you're using more than 8 doses of Onzetra (sumatriptan) a month, talk to your doctor to see if you should try another medicine.
  • You can only use each nosepiece of Onzetra (sumatriptan) once. Throw it away in the trash after you've checked that you used the medicine correctly.
Learn more
More about RelpaxSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Relpax (eletriptan)?
Worth itNot sureNot worth it
More about OnzetraSide effectsAlternativesFDA package insert
Have you used Onzetra (sumatriptan)?
Worth itNot sureNot worth it