Compare Remeron vs. Oleptro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Remeron
(Mirtazapine)

Oleptro
(Trazodone)

Improves mood. Remeron (Mirtazapine) is okay for treating depression and good for sleep. More likely to cause weight gain than any other antidepressant.Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.480314960629921Remeron
Reviews for Remeron (Mirtazapine)
47%
of people say Remeron (Mirtazapine) is worth it
42%
say it works well
26%
say it's a big hassle
Reviews for Oleptro (Trazodone)
72%
+25% vs. Remeron (Mirtazapine)
48%
+6% vs. Remeron (Mirtazapine)
24%
+2% vs. Remeron (Mirtazapine)
Side effects
RemeronOleptro
  • Drowsiness 36%
  • Increased appetite 15%
  • Dry mouth 10%
  • Weight gain 10%
  • Constipation 6%
  • Dizziness 4%
  • Muscle weakness 3%
  • Abnormal dreams 3%
  • Flu syndrome 2%
  • Thinking abnormal 2%
More Remeron side effects »
  • Somnolence/sedation 27%
  • Drowsiness 21%
  • Dry mouth 14%
  • Dizziness/lightheadedness 13%
  • Dizziness 13%
  • Blurred vision 11%
  • Nausea 8%
  • Fatigue 7%
  • Skin condition/edema 6%
  • Headache 6%
More Oleptro side effects »
How it works
RemeronOleptro
Remeron (Mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
RemeronOleptro
Antidepressant
Noradrenergic and specific serotonergic antidepressant
Prescription only
Antidepressant
Serotonin antagonist and reuptake inhibitor
Prescription only
Available as
RemeronOleptro
  • Pill
  • Dissolving tablet
  • Pill
  • Extended release
Used for (click to learn more)
RemeronOleptro
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.

After 4 weeks using Start and Remeron (Mirtazapine), here’s how much better people feel.

The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Oleptro (Trazodone)
Risk factors for serious side effects
RemeronOleptro
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • History of heart problems
  • History of liver problems
  • Higher dose
  • Alcohol
  • Taking other medicines that make you less alert
      Detailed Remeron (Mirtazapine) risks & warnings »
      • Age 24 years or younger
      • History of seizures
      • Alcoholism
      • Eating disorder
      • Higher dose
      • Drug interactions
        • Age 65 years or older
        • Alcohol
        • Taking other medicines that make you less alert
        Detailed Oleptro (Trazodone) risks & warnings »
        Pregnancy category
        RemeronOleptro
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.No specific alcohol-related info.
        Food
        No specific food-related info.No specific food-related info.
        Kidneys and liver
        No specific kidneys and liver-related info.No specific kidneys and liver-related info.
        Sex
        No specific sex-related info.
        • Fewer sexual side effects than many other antidepressants.
        • Seek medical attention for unwanted, persistent erection.
        • Rarely, Oleptro (Trazodone) can cause a painful, persistent erection for 4 hours or more. Seek medical attention.
        Sleep
        No specific sleep-related info.
        • Commonly used in lower doses to help treat sleep problems (insomnia).
        • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
        • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
        • Comes as a generic medication and is cheaper than many other sleep aides.
        Weight
        • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
        • Good option for people who are underweight or frail, because it can help you gain weight.
        • Can increase appetite and weight.
        • Remeron (Mirtazapine) can increase appetite and cause you to gain weight.
        No specific weight-related info.
        Upsides and benefits
        RemeronOleptro
        • Effective at relieving some depression symptoms.
        • Starts to work more quickly than most antidepressants.
        • Might be a good option for people who have insomnia with their depression, because it can make you very sleepy.
        • Good option for people who are underweight or frail, because it can help you gain weight.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        • Commonly used in lower doses to help treat sleep problems (insomnia).
        • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
        • Fewer sexual side effects than many other antidepressants.
        • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
        • Comes as a generic medication and is cheaper than many other sleep aides.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        Downsides and risks
        RemeronOleptro
        • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
        • Not as effective as other medications for depression.
        • More sedating than other antidepressants.
        • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
        • Not as effective as other medications for depression.
        • More sedating than other antidepressants.
        • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        Tips from our pharmacists for people taking the medication
        RemeronOleptro
        • Can increase appetite and weight.
        • Takes 8 to 12 weeks to see full effects on mood.
        • Stop taking slowly to avoid withdrawal symptoms.
        • Makes you sleepy. Take at bedtime.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        • Can cause temporary dry mouth and upset stomach.
        • Seek medical attention for unwanted, persistent erection.
        • Makes you sleepy. Take at bedtime.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        Learn more
        More about RemeronSide effectsReviews & ratingsAlternativesFDA package insert
        More about OleptroSide effectsReviews & ratingsAlternativesFDA package insert