Compare Remicade vs. Methotrexate

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Remicade
(infliximab)

Otrexup
(methotrexate)

Calms down your immune system. Remicade (infliximab) is an effective treatment for many autoimmune diseases, but you can have serious side effects.Treats cancer and changes how your immune system works. Otrexup (Methotrexate) is a first line treatment for many autoimmune diseases and types of cancer. If you're taking it for a long time, you'll have to get routine blood tests.
Reviews & ratings
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Filter group. All currently selected
5.44Remicade
Reviews for Remicade
76%
of people (All ages) say Remicade is worth it
62%
say it works well
15%
say it's a big hassle
Have you used Remicade (infliximab)?
Worth itNot sureNot worth it

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Have you used Otrexup (methotrexate)?
Worth itNot sureNot worth it
Side effects
RemicadeMethotrexate
  • Upper airway infection 7%
  • Nausea 1%
  • Headache 4%
  • Sinus infection 6%
  • Sore throat 4%
  • Coughinng 4%
  • Abdominal pain 4%
  • Bronchitis 1%
  • Rash 5%
More Remicade side effects »
  • Elevated liver function tests 15%
  • Nausea/vomiting 10%
  • Stomatitis 10%
  • Thrombocytopenia 10%
  • Rash/pruritus/dermatitis 3%
  • Diarrhea 3%
  • Alopecia 3%
  • Leukopenia 3%
  • Pancytopenia 3%
  • Dizziness 3%
More Methotrexate side effects »
How it works
RemicadeMethotrexate
Remicade (infliximab) blocks a protein in your immune system called TNF (tumor necrosis factor) that causes inflammation.Otrexup (Methotrexate) is an anti-cancer and immunosuppressive medication that treats forms of cancer, arthritis, and psoriasis. For cancer, it helps your body destroy cancer cells by blocking building blocks that cancer cells need to grow. For rheumatoid arthritis and psoriasis, it lowers the body's normal immune response and prevents the body from attacking itself.
Type of medication
RemicadeMethotrexate
Prescription onlyPrescription only
Available as
RemicadeMethotrexate
  • Injection
  • Pill
  • Injection
Used for
RemicadeMethotrexate
Risk factors for serious side effects
RemicadeMethotrexate
  • Taking other immunosuppressant drugs
  • Age 65 or older
  • Comorbidities
  • History of malignancy
Detailed Remicade (infliximab) risks & warnings »
  • Women of childbearing age
  • Men of childbearing potential
  • Reduced kidney function
  • fluid in the abdomen (ascites)
  • fluid in the lungs (pleural effusion)
Detailed Otrexup (methotrexate) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Alcohol
RemicadeMethotrexate
No alcohol related info.
  • Don't use alcohol, NSAIDs (anti-inflammatory medications), or stay in the sun too long.
  • You have to avoid alcohol and being in the sun too long.
Weight
RemicadeMethotrexate
  • Although rare, Remicade (infliximab) can hurt your liver. If you have appetite/weight loss, stomach discomfort, vomiting, or dark urine, talk to your doctor. If you have yellowing of skin/eyes, talk to your doctor right away.
No weight related info.
Upsides and benefits
RemicadeMethotrexate
  • People taking Remicade (infliximab) for ulcerative colitis, Crohn's disease, rheumatoid arthritis and other autoimmune conditions had more clinical response, clinical remission and symptom improvement compared to people who did not take Remicade (infliximab).
  • People who were also taking steroids for treatment were able to discontinue steroid use while taking Remicade (infliximab).
  • Remicade (infliximab) has almost two decades of clinical trial data and real-life experience with many people who have used it.
  • After the initial dosing, you only need to take Remicade (infliximab) every 6-8 weeks, depending on your condition.
  • Compared to other medications used to treat autoimmune conditions, Remicade (infliximab) has not been associated with as many harmful effects during pregnancy and breastfeeding.
  • Recommended as first line treatment for rheumatoid arthritis.
  • Available as a generic medication. Comes as a tablet, an injection that you give yourself weekly, and as an infusion that you get in your doctor's office or at an infusion center.
  • If you accidentally take too much, there's an antidote to help your body recover.
Downsides and risks
RemicadeMethotrexate
  • You have to receive this medication at your doctor's office or clinic. You might need to be tested regularly for tuberculosis.
  • Remicade (infliximab) lowers your ability to fight infection and can cause serious illness. The risk is greater if you take other drugs that lower your immune system, or have a history of diabetes or tuberculosis.
  • Remicade (infliximab) can in some cases worsen symptoms of heart failure or neurologic conditions. People 65 years and older may have more side effects from this medication.
  • In rare cases, Remicade (infliximab) has been associated with cancers in children and adolescents.
  • No generic available, so it can be costly.
  • You have to be on birth control for at least 2 to 3 months after you finish Otrexup (Methotrexate) since it can cause birth defects.
  • You have to avoid alcohol and being in the sun too long.
  • You'll have to get blood tests done if you're taking this long-term because it can cause harmful side effects.
Tips from our pharmacists for people taking the medication
RemicadeMethotrexate
  • Remicade (infliximab) can in some cases cause a serious allergic reaction either immediately or several days after the treatment. Your doctor can give you medicines that will lower this risk.
  • Your doctor will test you for tuberculosis before taking Remicade (infliximab) and regularly during treatment.
  • Remicade (infliximab) lowers your immune system's ability to fight infections, so it's important to let your doctor know if you notice a fever, cough, or flu-like symptoms.
  • You should not receive any live vaccines while taking Remicade (infliximab). Tell your doctor that you are taking Remicade (infliximab) before receiving any vaccines.
  • If you have any signs or new or worsening symptoms such as heart, neurological, or autoimmune conditions, talk to your doctor. Tell your doctor about symptoms such as bruising or bleeding.
  • Don't use alcohol, NSAIDs (anti-inflammatory medications), or stay in the sun too long.
  • Use birth control and avoid pregnancy for at least 2 months (for women) and 3 months (for men) after you finish Otrexup (Methotrexate).
  • Drink plenty of liquids to stay hydrated while taking this.
  • Take the medication exactly as your doctor or pharmacist tells you. Call your doctor or pharmacist if you're confused.
Learn more
More about RemicadeSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Remicade (infliximab)?
Worth itNot sureNot worth it
More about MethotrexateSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Otrexup (methotrexate)?
Worth itNot sureNot worth it