Compare Remicade vs. Rituxan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Remicade
(Infliximab)

Rituxan
(Rituximab)

Calms down your immune system. Remicade (Infliximab) is very effective at calming down your immune system, but you have to get each dose at your doctor's office and watch out for serious side effects.Calms down your immune system. Rituxan (Rituximab) is effective for treating multiple types of cancer and arthritis. That said, you'll need to watch for possibly serious side effects, especially infusion reactions.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.458333333333333Remicade
Reviews for Remicade (Infliximab)
77%
of people say Remicade (Infliximab) is worth it
65%
say it works well
13%
say it's a big hassle

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Side effects
RemicadeRituxan
  • Infusion reaction 13%
  • Infections 11%
More Remicade side effects »
  • Low blood phosphate 11%
  • Acute infusion reactions 8%
  • Cardiac side effect 1%
More Rituxan side effects »
How it works
RemicadeRituxan
Remicade (Infliximab) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.Rituxan (Rituximab) is a monoclonal antibody. It targets a specific protein on white blood cells that makes it easier for your immune system to find and destroy cancerous cells. It also relieves symptoms and slows the progression of Rheumatoid Arthritis.
Type of medication
RemicadeRituxan
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Anticancer
Biological response modifier
Prescription only
Available as
RemicadeRituxan
  • Injection
  • Infusion (IV)
Used for (click to learn more)
RemicadeRituxan
Risk factors for serious side effects
RemicadeRituxan
    • History of heart failure
    • Taking other immunosuppressant drugs
    • Age 60 or older
    • Taking other immunosuppressant drugs
    • History of malignancy
    • History of neurologic condition
        Detailed Remicade (Infliximab) risks & warnings »
          • Taking other immunosuppressant drugs
          • Age 60 or older
          • Weak immune system
          • Taking Rituxan (Rituximab) with immunosuppressant drugs (if using for RA)
          • Taking Rituxan (Rituximab) with chemotherapy (if using for NHL or CLL
          • Stem cell transplant
            • Taking Rituxan (Rituximab) for Non-Hodgkin's Lymphoma (NHL)
            • Rapidly growing tumors
            • History of heart problems
            • Drug interactions
            • Start of therapy with Rituxan (Rituximab)
              Detailed Rituxan (Rituximab) risks & warnings »
              Pregnancy category
              RemicadeRituxan
              BFDA pregnancy category (Probably safe)

              Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

              See the FDA package insert
              CFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              Alcohol
              No specific alcohol-related info.No specific alcohol-related info.
              Food
              No specific food-related info.No specific food-related info.
              Kidneys and liver
              No specific kidneys and liver-related info.
              • Discuss with your doctor the serious heart, kidney, liver, or stomach problems that can happen while on Rituxan (Rituximab).
              • Tumor lysis syndrome (TLS) happens when cancer cells are broken down very quickly and damage the kidneys. The damage can be so bad that people need dialysis. If you're taking Rituxan (Rituximab) for a cancer condition your doctor can give you medicines and take measures to prevent this reaction.
              Sex
              No specific sex-related info.No specific sex-related info.
              Sleep
              No specific sleep-related info.No specific sleep-related info.
              Weight
              • Remicade (Infliximab) can increase your risk of serious or life-threatening bacterial, fungal and viral infections. In some cases infections can be reactivated from an inactive virus in your body like tuberculosis (TB) or hepatitis B virus (HBV). You may need to take medicine for TB before you can begin taking Remicade (Infliximab). If you develop symptoms of cough, fever, chills, muscle aches, feel very tired, or you notice dark urine, yellowing of skin/eyes, appetite/weight loss, vomiting, change in stool color, stomach discomfort, and skin rash, tell your doctor and get medical care right away.
              • Although rare, Remicade (Infliximab) can cause serious liver injury. You'll need to have your liver enzymes tested regularly. If liver enzymes are significantly elevated and you have appetite/weight loss, stomach discomfort, vomiting, and notice dark urine, yellowing of skin/eyes, change in stool color, and skin rash you should stop treatment with Remicade (Infliximab) until you can be completely assessed,
              • Rituxan (Rituximab) can increase your risk of serious or life-threatening bacterial, fungal and viral infections including sepsis. In some cases infections can be reactivated from an inactive virus in your body like tuberculosis (TB) or hepatitis B virus (HBV). You may need to take medicine for TB before you can begin taking Rituxan (Rituximab). If you develop symptoms of cough, fever, chills, muscle aches, feel very tired, or you notice dark urine, yellowing of skin/eyes, appetite/weight loss, vomiting, change in stool color, stomach discomfort, and skin rash, tell your doctor and get medical care right away.
              Upsides and benefits
              RemicadeRituxan
              • Treats certain types of arthritis and gastrointestinal conditions caused by an overactive immune system.
              • Remicade has almost two decades of clinical trial data and real-life experience with millions of people who have used it.
              • Initial dosing to introduce Remicade to your body might be a hassle, but then you only need to take it every 6-8 weeks depending on your condition.
              • Treats leukemia, lymphoma, and blood vessel inflammation.
              • Also treats moderate to severe rheumatoid arthritis that hasn't responded to anti-TNF treatment (but you'll need to take methotrexate too).
              • The chance of having a reaction to the infusion is highest during your first dose, but the risk decreases each time you get Rituxan (Rituximab). It usually happens within 30 minutes to 2 hours after starting the infusion.
              • Rituxan (Rituximab) is a targeted therapy that works differently than chemotherapy. Both work well when they're taken together, especially when treating CLL and NHL.
              Downsides and risks
              RemicadeRituxan
              • You have to get every dose through an IV infusion at your doctor's office.
              • It's expensive because there's no generic available yet.
              • Remicade has a higher risk of serious infusion-related side effects during or after it's given since it's injected right into your veins. Your doctor can prescribe medication before your dose that may lower this risk.
              • Remicade lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
              • Not the best choice if you have heart failure.
              • Talk to your baby's doctor if you're pregnant or breast-feeding. When women in a study took Remicade (Infliximab), the medicine was found in their breast milk 2 to 3 days after each dose, and in the baby's blood 6 months after they were born.
              • Only your doctor or other trained medical staff can administer Rituxan (Rituximab), so you'll need to go into an office or clinic for every dose.
              • Not the best choice if you have heart problems.
              • Rituxan (Rituximab) can stay in your body for up to 6 months after you complete treatment. Men and women who are able to have children need to use birth control for up to one year after finishing Rituxan (Rituximab).
              • Discuss with your doctor the serious heart, kidney, liver, or stomach problems that can happen while on Rituxan (Rituximab).
              Tips from our pharmacists for people taking the medication
              RemicadeRituxan
              • Remicade (Infliximab) is a medication that's given as an infusion at your doctor's office or clinic.
              • It's very important to read the patient Medication Guide when you first start using Remicade (Infliximab).
              • It's possible to get an allergic reaction to Remicade (Infliximab) either immediately during the treatment or a several days after stopping it. Your doctor can give you medicines that'll lower this risk.
              • You'll need to have a TB test before you start taking Remicade (Infliximab) and periodically during treatment.
              • Remicade (Infliximab) lowers your immune system's ability to fight infections, so it's important to let your doctor know if you notice a fever, cough, or flu-like symptoms. Children seem to get more infections than adults, so keep a close eye on them.
              • If you have a young child, let their doctor know if you were on Remicade (Infliximab) while pregnant or nursing. It can increase their risk of infections for several months after your last dose and can delay their vaccine schedule.
              • Rituxan (Rituximab) is given as an IV infusion by trained medical staff in a clinic or hospital.
              • You'll need to be monitored in the clinic in case you have a serious or life-threatening reaction during the infusion, but you can take other medications that'll lower your risk of this happening.
              • It's very important that you read the Medication Guide before you start taking Rituxan (Rituximab).
              • Rituxan (Rituximab) lowers your immune system's ability to fight infections, so it's important to let your doctor know if you notice a fever, a cough that doesn't go away, or flu-like symptoms.
              • Use effective birth control while you're taking Rituxan (Rituximab) and for 12 months after you finish treatment.
              • Don't get live vaccines while you're taking Rituxan (Rituximab).
              Learn more
              More about RemicadeSide effectsReviews & ratingsAlternativesFDA package insert
              More about RituxanSide effectsReviews & ratingsAlternativesFDA package insert