Compare Remicade vs. Rituxan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Remicade
(infliximab)

Rituxan
(Rituximab)

Calms down your immune system. Remicade (infliximab) is an effective treatment for many autoimmune diseases, but you can have serious side effects.Calms down your immune system. Rituxan (Rituximab) is effective for treating multiple types of cancer and arthritis. That said, you'll need to watch for possibly serious side effects, especially infusion reactions.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.44Remicade
Reviews for Remicade
76%
of people (All ages) say Remicade is worth it
62%
say it works well
15%
say it's a big hassle
Have you used Remicade (infliximab)?
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Have you used Rituxan (Rituximab)?
Worth itNot sureNot worth it
Side effects
RemicadeRituxan
  • Yeast infectionn 2%
  • Itchiness 5%
  • Fever 3%
  • High blood pressure 2%
  • Pain 1%
  • Joint pain 1%
  • Urinary tract infection 2%
  • Fatigue 2%
  • Indigestion 3%
  • Bronchitis 1%
More Remicade side effects »
  • Chills 13%
  • Cardiac disorder 28%
  • Lung disorder 31%
  • Pyrexia 60%
  • Any serious infection 1%
  • Cardiac side effect 1%
  • Infusion reaction 12%
  • Any infection 5%
  • Tested positive for HACA 23%
More Rituxan side effects »
How it works
RemicadeRituxan
Remicade (infliximab) blocks a protein in your immune system called TNF (tumor necrosis factor) that causes inflammation.Rituxan (Rituximab) is a monoclonal antibody. It targets a specific protein on white blood cells that makes it easier for your immune system to find and destroy cancerous cells. It also relieves symptoms and slows the progression of Rheumatoid Arthritis.
Type of medication
RemicadeRituxan
Prescription onlyNo lower cost generic availablePrescription onlyNo lower cost generic available
Available as
RemicadeRituxan
  • Injection
  • Infusion (iv)
Used for
RemicadeRituxan
Risk factors for serious side effects
RemicadeRituxan
  • Taking other immunosuppressant drugs
  • Age 65 or older
  • Comorbidities
  • History of malignancy
Detailed Remicade (infliximab) risks & warnings »
  • Taking other immunosuppressant drugs
  • Age 60 or older
  • Weak immune system
  • Taking Rituxan (Rituximab) with immunosuppressant drugs (if using for RA)
  • Taking Rituxan (Rituximab) with chemotherapy (if using for NHL or CLL
Detailed Rituxan (Rituximab) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
RemicadeRituxan
No kidneys and liver related info.
  • Discuss with your doctor the serious heart, kidney, liver, or stomach problems that can happen while on Rituxan (Rituximab).
Weight
RemicadeRituxan
  • Although rare, Remicade (infliximab) can hurt your liver. If you have appetite/weight loss, stomach discomfort, vomiting, or dark urine, talk to your doctor. If you have yellowing of skin/eyes, talk to your doctor right away.
No weight related info.
Upsides and benefits
RemicadeRituxan
  • People taking Remicade (infliximab) for ulcerative colitis, Crohn's disease, rheumatoid arthritis and other autoimmune conditions had more clinical response, clinical remission and symptom improvement compared to people who did not take Remicade (infliximab).
  • People who were also taking steroids for treatment were able to discontinue steroid use while taking Remicade (infliximab).
  • Remicade (infliximab) has almost two decades of clinical trial data and real-life experience with many people who have used it.
  • After the initial dosing, you only need to take Remicade (infliximab) every 6-8 weeks, depending on your condition.
  • Compared to other medications used to treat autoimmune conditions, Remicade (infliximab) has not been associated with as many harmful effects during pregnancy and breastfeeding.
  • Treats leukemia, lymphoma, and blood vessel inflammation.
  • Also treats moderate to severe rheumatoid arthritis that hasn't responded to anti-TNF treatment (but you'll need to take methotrexate too).
  • The chance of having a reaction to the infusion is highest during your first dose, but the risk decreases each time you get Rituxan (Rituximab). It usually happens within 30 minutes to 2 hours after starting the infusion.
  • Rituxan (Rituximab) is a targeted therapy that works differently than chemotherapy. Both work well when they're taken together, especially when treating CLL and NHL.
Downsides and risks
RemicadeRituxan
  • You have to receive this medication at your doctor's office or clinic. You might need to be tested regularly for tuberculosis.
  • Remicade (infliximab) lowers your ability to fight infection and can cause serious illness. The risk is greater if you take other drugs that lower your immune system, or have a history of diabetes or tuberculosis.
  • Remicade (infliximab) can in some cases worsen symptoms of heart failure or neurologic conditions. People 65 years and older may have more side effects from this medication.
  • In rare cases, Remicade (infliximab) has been associated with cancers in children and adolescents.
  • No generic available, so it can be costly.
  • Only your doctor or other trained medical staff can administer Rituxan (Rituximab), so you'll need to go into an office or clinic for every dose.
  • Not the best choice if you have heart problems.
  • Rituxan (Rituximab) can stay in your body for up to 6 months after you complete treatment. Men and women who are able to have children need to use birth control for up to one year after finishing Rituxan (Rituximab).
  • Discuss with your doctor the serious heart, kidney, liver, or stomach problems that can happen while on Rituxan (Rituximab).
Tips from our pharmacists for people taking the medication
RemicadeRituxan
  • Remicade (infliximab) can in some cases cause a serious allergic reaction either immediately or several days after the treatment. Your doctor can give you medicines that will lower this risk.
  • Your doctor will test you for tuberculosis before taking Remicade (infliximab) and regularly during treatment.
  • Remicade (infliximab) lowers your immune system's ability to fight infections, so it's important to let your doctor know if you notice a fever, cough, or flu-like symptoms.
  • You should not receive any live vaccines while taking Remicade (infliximab). Tell your doctor that you are taking Remicade (infliximab) before receiving any vaccines.
  • If you have any signs or new or worsening symptoms such as heart, neurological, or autoimmune conditions, talk to your doctor. Tell your doctor about symptoms such as bruising or bleeding.
  • Rituxan (Rituximab) is given as an IV infusion by trained medical staff in a clinic or hospital.
  • You'll need to be monitored in the clinic in case you have a serious or life-threatening reaction during the infusion, but you can take other medications that'll lower your risk of this happening.
  • It's very important that you read the Medication Guide before you start taking Rituxan (Rituximab).
  • Rituxan (Rituximab) lowers your immune system's ability to fight infections, so it's important to let your doctor know if you notice a fever, a cough that doesn't go away, or flu-like symptoms.
  • Use effective birth control while you're taking Rituxan (Rituximab) and for 12 months after you finish treatment.
  • Don't get live vaccines while you're taking Rituxan (Rituximab).
Learn more
More about RemicadeSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Remicade (infliximab)?
Worth itNot sureNot worth it
More about RituxanSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Rituxan (Rituximab)?
Worth itNot sureNot worth it