Compare Remicade vs. Simponi

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Calms down your immune system. Remicade (infliximab) is an effective treatment for many autoimmune diseases, but you can have serious side effects.Calms down the immune system. Simponi (golimumab) effectively calms down your immune system, but it is given as a shot and puts you at risk of serious infections like tuberculosis or hepatitis B.
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Best available price for 18 (100mg) vials of remicade
Reviews & ratings
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Reviews for Remicade
of people (All ages) say Remicade is worth it
say it works well
say it's a big hassle
Have you used Remicade (infliximab)?
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Have you used Simponi (golimumab)?
Worth itNot sureNot worth it
Side effects
  • Upper airway infection 7%
  • Nausea 1%
  • Headache 4%
  • Sinus infection 6%
  • Sore throat 4%
  • Coughinng 4%
  • Abdominal pain 4%
  • Bronchitis 1%
  • Rash 5%
More Remicade side effects »
  • Common cold 3%
  • Injection site reaction 4%
  • Viral infections (such as influenza and herpes) 2%
  • Increased liver function test (alt) 1%
  • Increased liver function test (ast) 1%
  • High blood pressure 1%
  • Bronchitis 1%
  • Superficial fungal infections 1%
  • Tingling sensation 1%
  • Dizziness 1%
More Simponi side effects »
How it works
Remicade (infliximab) blocks a protein in your immune system called TNF (tumor necrosis factor) that causes inflammation.Simponi (golimumab) blocks a protein called TNF (tumor necrosis factor) that revs up the immune system. Blocking TNF lowers inflammation, relieves symptoms and prevents disease progression. Simponi (golimumab) is also known as a biologic DMARD (disease-modifying anti-rheumatic drug) - or just a "biologic" - when used to treat rheumatoid arthritis.
Type of medication
Prescription onlyPrescription only
Available as
  • Injection
  • Injection
Used for
Risk factors for serious side effects
  • Taking other immunosuppressant drugs
  • Age 65 or older
  • Comorbidities
  • History of malignancy
Detailed Remicade (infliximab) risks & warnings »
  • Taking other immunosuppressant drugs
  • Age 65 or older
  • Active, chronic, or recurrent infection
  • History of malignancy
Detailed Simponi (golimumab) risks & warnings »
  • Although rare, Remicade (infliximab) can hurt your liver. If you have appetite/weight loss, stomach discomfort, vomiting, or dark urine, talk to your doctor. If you have yellowing of skin/eyes, talk to your doctor right away.
No weight related info.
Upsides and benefits
  • People taking Remicade (infliximab) for ulcerative colitis, Crohn's disease, rheumatoid arthritis and other autoimmune conditions had more clinical response, clinical remission and symptom improvement compared to people who did not take Remicade (infliximab).
  • People who were also taking steroids for treatment were able to discontinue steroid use while taking Remicade (infliximab).
  • Remicade (infliximab) has almost two decades of clinical trial data and real-life experience with many people who have used it.
  • After the initial dosing, you only need to take Remicade (infliximab) every 6-8 weeks, depending on your condition.
  • Compared to other medications used to treat autoimmune conditions, Remicade (infliximab) has not been associated with as many harmful effects during pregnancy and breastfeeding.
  • Simponi (golimumab) is only injected once a month.
  • Simponi (golimumab) comes in a prefilled syringe or autoinjector. You won't need to measure out the medication.
  • While taking Simponi (golimumab), you may continue to use other drugs prescribed by your doctor that help treat your condition, such as NSAIDS (like ibuprofen) and steroids.
Downsides and risks
  • You have to receive this medication at your doctor's office or clinic. You might need to be tested regularly for tuberculosis.
  • Remicade (infliximab) lowers your ability to fight infection and can cause serious illness. The risk is greater if you take other drugs that lower your immune system, or have a history of diabetes or tuberculosis.
  • Remicade (infliximab) can in some cases worsen symptoms of heart failure or neurologic conditions. People 65 years and older may have more side effects from this medication.
  • In rare cases, Remicade (infliximab) has been associated with cancers in children and adolescents.
  • No generic available, so it can be costly.
  • Like other immunosuppressive drugs, Simponi (golimumab) can awaken (reactivate) infections.
  • Simponi (golimumab) can increase the risk of lymphoma, leukemia, and other cancers.
  • Not the best choice if you have a history of heart failure or nervous system problems like multiple sclerosis.
  • You'll need to have regular blood tests before and during treatment to make sure you don't have any problems taking Simponi (golimumab).
Tips from our pharmacists for people taking the medication
  • Remicade (infliximab) can in some cases cause a serious allergic reaction either immediately or several days after the treatment. Your doctor can give you medicines that will lower this risk.
  • Your doctor will test you for tuberculosis before taking Remicade (infliximab) and regularly during treatment.
  • Remicade (infliximab) lowers your immune system's ability to fight infections, so it's important to let your doctor know if you notice a fever, cough, or flu-like symptoms.
  • You should not receive any live vaccines while taking Remicade (infliximab). Tell your doctor that you are taking Remicade (infliximab) before receiving any vaccines.
  • If you have any signs or new or worsening symptoms such as heart, neurological, or autoimmune conditions, talk to your doctor. Tell your doctor about symptoms such as bruising or bleeding.
  • Simponi (golimumab) is an immunosuppressant medication that's injected under the skin (subcutaneous) once a month.
  • Simponi (golimumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
  • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
  • Each time you use Simponi (golimumab), it's important to rotate the sites you chose to inject it in (either your abdomen, thigh, or upper arm). Don't inject Simponi (golimumab) into skin that's red, bruised, or irritated.
  • Keep it refrigerated, and let it sit at room temperature for about 30 minutes before injecting yourself. Do not shake the Simponi (golimumab) autoinjector at any time.
  • People taking Simponi (golimumab) should not get live vaccines. Talk to your doctor before receiving any vaccines.
Learn more
More about RemicadeSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Remicade (infliximab)?
Worth itNot sureNot worth it
More about SimponiSide effectsAlternativesFDA package insert
Have you used Simponi (golimumab)?
Worth itNot sureNot worth it