Compare Renova vs. Minocycline

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Treats acne and sun damage. Renova (Tretinoin) isn't a cure for fine lines and wrinkles, but it's clinically proven to improve them.Treats bacterial infections. Solodyn (Minocycline) is an effective way to treat certain skin infections, acne, and rosacea, but you'll need to use barrier methods of birth control since it can make birth control pills less effective and cause birth defects.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Renova (Tretinoin)
of people (All ages) say Renova (Tretinoin) is worth it
say it works well
say it's a big hassle
Have you used Renova (Tretinoin)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Solodyn (Minocycline)?
Worth itNot sureNot worth it
Side effects
  • Severe local irritation 6%
More Renova side effects »

We haven’t found good data for Minocycline side effects.

FDA side effect reports for Minocycline »
How it works
Renova (Tretinoin) is a vitamin A derivative. Researchers don't know exactly how it works, but it seems to make skin cells renew faster and better.Solodyn (Minocycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.
Type of medication
Acne agent
Prescription only
Prescription only
Available as
  • Cream, gel, or ointment
  • Pill
  • Extended release
  • Extended release capsule
Used for (click to learn more)
Risk factors for serious side effects
  • Using other medicines or products that irritate the skin
  • Eczema
  • Extreme temperatures (hot or cold)
    • Allergy to fish or fish products
      Detailed Renova (Tretinoin) risks & warnings »
      • Age 8 years or younger
      • Using oral birth control pills
      • Long antibiotic treatment period
          • Women of childbearing age
          Detailed Solodyn (Minocycline) risks & warnings »

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Upsides and benefits
          • You only need to apply it once a day, usually in the evening.
          • Most people who reported having skin irritation said that it was mild.
          • Part of a complete program to help you take better care of your skin.
          • Clinical studies show it's effective against MRSA, a common skin infection, and it's commonly used to treat acne and rosacea.
          • Available as a generic, so it should be reasonably priced.
          • Solodyn (Minocycline) is less likely to cause sunburn than other tetracycline antibiotics.
          • Bacteria are less likely to become resistant to Solodyn (Minocycline) than other tetracycline antibiotics.
          Downsides and risks
          • It may take up to 6 months to see the full benefit for facial wrinkles.
          • Not a good choice for women who want to become or are pregnant
          • Can change the color and texture of your skin if used long-term.
          • You need to be careful about avoiding any sunlight or artificial tanning while using it.
          • It doesn't work for deep wrinkles.
          • It can make birth control pills less effective, so people should use barrier methods of birth control like condoms or diaphragms while on Solodyn (Minocycline).
          • Can stain your teeth, mouth, and gums if you're using the tablets, or your skin if you're using the topical version, but this is temporary.
          Tips from our pharmacists for people taking the medication
          • Works best as part of a complete skin care program (including SPF) to protect your skin from sun damage.
          • Renova doesn't permanently erase or improve significant skin changes such as deep wrinkles.
          • Apply a very small amount (pea-size) on entire face once a day at bedtime.
          • You'll need to use Renova regularly for at least 3 to 4 months before you see improvement. Once you stop, the improvement may slowly disappear.
          • Renova wasn't studied in people with skin cancer or serious damage from the sun (actinic keratosis) so it's not known if this would benefit.
          • Not safe to use during pregnancy. Even though Renova is applied to the skin, a small amount is absorbed and harmful to your unborn baby.
          • Some medicines you take by mouth can make you more sensitive to sunlight and combine with effects of Renova. Check with your doctor or pharmacist before you take any new medicines.
          • Both men and women should use barrier methods of birth control while on Solodyn (Minocycline) since it can cause birth defects and make birth control pills less effective.
          • Can make you dizzy, so be careful if you're getting up from lying down or sitting. Don't drive until you know how it affects you.
          • Can stain your teeth, tongue and gums, but this is temporary.
          • Take this exactly how your doctor or pharmacist tells you until it's all gone.
          • Don't eat any dairy products or take any vitamins within 2 hours of taking Solodyn (Minocycline) because they can make the medication less effective.
          Learn more
          More about RenovaSide effectsReviews & ratingsFDA package insert
          Have you used Renova (Tretinoin)?
          Worth itNot sureNot worth it
          More about MinocyclineSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Solodyn (Minocycline)?
          Worth itNot sureNot worth it