Compare Risperdal vs. Saphris

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Risperdal
(Risperidone)

Saphris
(asenapine)

Helps control your thoughts and mood. Risperdal (Risperidone) is good for treating psychosis, mania, and irritability. Among newer antipsychotic medicines, more likely to cause side effects, especially weight gain and hormone problems.Treats bipolar disorder and schizophrenia. While Saphris (asenapine) has fewer side effects compared with other medicines that treat bipolar disorder and schizophrenia, it can be more expensive.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.53Risperdal
Reviews for Risperdal
42%
of people (All ages) say Risperdal is worth it
47%
say it works well
49%
say it's a big hassle
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Have you used Saphris (asenapine)?
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Side effects
RisperdalSaphris
  • Vision blurred 1%
  • Stomach discomfort 2%
  • Fatigue 1%
  • Lethargy 1%
  • Diarrhea 1%
  • Salivary hypersecretion 2%
  • Nausea 3%
  • Dystonia 4%
  • Tremor 3%
  • Dizziness 1%
More Risperdal side effects »
  • Dry mouth 1%
  • Drooling 2%
  • Stomach discomfort 1%
  • Irritability 1%
  • Increased appetite 1%
  • Weight gain 2%
  • Numbness in the mouth 4%
More Saphris side effects »
How it works
RisperdalSaphris
Risperdal (Risperidone) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.While it's not clear how Saphris (asenapine) helps to treat bipolar disorder or schizophrenia, it changes the amount of dopamine and serotonin in the brain, two chemicals that are known to regulate mood.
Type of medication
RisperdalSaphris
Prescription onlyLower-cost generic availablePrescription onlyNo lower cost generic available
Available as
RisperdalSaphris
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
  • Dissolving pill
Used for
RisperdalSaphris
Risk factors for serious side effects
RisperdalSaphris
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Risperdal (Risperidone) risks & warnings »
  • People age 65 or older with dementia and psychosis
  • Taking antipsychotic medications
  • High blood pressure
  • History of heart disease
Detailed Saphris (asenapine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
RisperdalSaphris
  • Risperdal (Risperidone) can increase your blood sugar and cholesterol. Exercise and eat healthy food to lower your risk.
No food related info.
Sleep
RisperdalSaphris
  • Can cause dizziness and drowsiness.
No sleep related info.
Weight
RisperdalSaphris
  • Risperdal (Risperidone) can cause you to gain weight. Exercise and eat healthy food to lower your risk.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Moderate risk of weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
  • People on medicines like Saphris (asenapine) have had weight gain and higher blood sugar to the point of having diabetes. Your doctor will work with you to stop that from happening.
Upsides and benefits
RisperdalSaphris
  • Effective at relieving psychotic symptoms, manic episodes, irritability, and aggressive behavior.
  • Lowers relapse rates in people with schizophrenia and people with irritability associated with autism.
  • Antipsychotic medicines are all about equally effective.
  • Less likely to cause heart problems than some antipsychotics.
  • Saphris (asenapine) can be used to treat bipolar disorder in children age 10 or older, and schizophrenia in children age 12 or older.
  • You don't need water to take Saphris (asenapine); the pill dissolves in your mouth right away.
  • Compared to other medicines, the side effects of Saphris (asenapine) are milder.
Downsides and risks
RisperdalSaphris
  • Mild to moderate risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • Moderate risk of weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
  • Compared to other antipsychotics, higher risk of hormone problems that cause nipples to leak and male breasts to grow abnormally large.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
  • Saphris (asenapine) is only available as a brand name.
  • Compared to other medicines, Saphris (asenapine) can cause changes in your hormones and make you sleepy.
  • You have to take Saphris (asenapine) twice a day, which can be hard to remember.
Tips from our pharmacists for people taking the medication
RisperdalSaphris
  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
  • Can cause dizziness and drowsiness.
  • For the first week, avoid activities that require you to be alert.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take it.
  • To take Saphris (asenapine), place the pill under your tongue and let it dissolve completely. Don't chew or swallow the pill, and don't eat or drink for 10 minutes after you take it.
  • You might feel numbness or tingling in your mouth or throat after you take Saphris (asenapine). This usually goes away after an hour.
  • Don't drive or do anything requiring concentration until you know how Saphris (asenapine) affects you.
  • Don't stop taking Saphris (asenapine) suddenly without talking to your doctor first because it can be very dangerous.
  • If you miss a dose of Saphris (asenapine), take it as soon as you remember, unless it’s time for your next dose; don't take 2 doses at the same time.
  • Keep Saphris (asenapine) in your pantry away from heat, moisture, and light. Don't store it in your bathroom's medicine cabinet.
Learn more
More about RisperdalSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Risperdal (Risperidone)?
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More about SaphrisSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Saphris (asenapine)?
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