Compare Risperdal vs. Seroquel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Risperdal
(risperidone)

Seroquel
(quetiapine)

Helps control your thoughts and mood. Risperdal (Risperidone) is good for treating psychosis, mania, and irritability. Among newer antipsychotic medicines, more likely to cause side effects, especially weight gain and hormone problems.Helps control your thoughts and mood. Seroquel (Quetiapine) is good for treating psychosis and mania. Fewer side effects than most antipsychotics, but might be less effective for people over age 40 with schizophrenia.
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Coupons for Risperdal
Best available price for 30 (1mg) tablets of risperdal
Coupons for Seroquel
Best available price for 30 (25mg) tablets of seroquel
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.53Risperdal
Reviews for Risperdal
42%
of people (All ages) say Risperdal is worth it
47%
say it works well
49%
say it's a big hassle
Have you used Risperdal (risperidone)?
Worth itNot sureNot worth it
Reviews for Seroquel
56%
-14% worse vs. Risperdal
50%
-3% worse vs. Risperdal
27%
-22% worse vs. Risperdal
250 reviews
Have you used Seroquel (quetiapine)?
Worth itNot sureNot worth it
Side effects
RisperdalSeroquel
  • Parkinsonism 16%
  • Relaxation or sleepiness 7%
  • Restlessness 6%
  • Tremor 3%
  • Dizziness 1%
  • Nausea 3%
  • Muscle twitching 4%
  • Diarrhea 1%
  • Excessive saliva 2%
  • Vision blurred 1%
More Risperdal side effects »
  • Drowsiness 42%
  • Dizziness 15%
  • Nausea 6%
  • Fatigue 5%
  • Increased appetite 8%
  • Abnormally fast heart beat 8%
  • Vomiting 4%
  • Dry mouth 7%
  • Nasal congestion 4%
  • Weight increased 6%
More Seroquel side effects »
How it works
RisperdalSeroquel
Risperdal (Risperidone) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Seroquel (Quetiapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.
Type of medication
RisperdalSeroquel
Prescription onlyPrescription only
Available as
RisperdalSeroquel
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
  • Pill
  • Extended release
Used for
RisperdalSeroquel
Risk factors for serious side effects
RisperdalSeroquel
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Risperdal (risperidone) risks & warnings »
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Seroquel (quetiapine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
RisperdalSeroquel
  • Risperdal (Risperidone) can increase your blood sugar and cholesterol. Exercise and eat healthy food to lower your risk.
  • Seroquel (Quetiapine) can increase your blood sugar and cholesterol. Seroquel (Quetiapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
Sleep
RisperdalSeroquel
  • Can cause dizziness and drowsiness.
  • Can cause dizziness, drowsiness, and low blood pressure.
Weight
RisperdalSeroquel
  • Risperdal (Risperidone) can cause you to gain weight. Exercise and eat healthy food to lower your risk.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Moderate risk of weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
  • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Sometimes causes weight gain, sleepiness, and low blood pressure.
Upsides and benefits
RisperdalSeroquel
  • Effective at relieving psychotic symptoms, manic episodes, irritability, and aggressive behavior.
  • Lowers relapse rates in people with schizophrenia and people with irritability associated with autism.
  • Antipsychotic medicines are all about equally effective.
  • Less likely to cause heart problems than some antipsychotics.
  • Effective at relieving psychotic symptoms and manic episodes.
  • Antipsychotic medicines are all about equally effective.
  • Fewer side effects than most antipsychotic medicines.
  • Less likely to cause heart problems compared to some antipsychotics.
  • Compared to other antipsychotics, the least likely to cause Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
Downsides and risks
RisperdalSeroquel
  • Mild to moderate risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • Moderate risk of weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
  • Compared to other antipsychotics, higher risk of hormone problems that cause nipples to leak and male breasts to grow abnormally large.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
  • In studies, less effective for people over age 40 for schizophrenia.
  • Sometimes causes weight gain, sleepiness, and low blood pressure.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
Tips from our pharmacists for people taking the medication
RisperdalSeroquel
  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
  • Can cause dizziness and drowsiness.
  • For the first week, avoid activities that require you to be alert.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take it.
  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
  • Can cause dizziness, drowsiness, and low blood pressure.
  • For the first week, avoid activities that require you to be alert.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take it.
Learn more
More about RisperdalSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Risperdal (risperidone)?
Worth itNot sureNot worth it
More about SeroquelSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Seroquel (quetiapine)?
Worth itNot sureNot worth it