Compare Risperdal vs. Seroquel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Risperdal
(Risperidone)

Seroquel
(Quetiapine)

Helps control your thoughts and mood. Risperdal (Risperidone) is good for treating psychosis, mania, and irritability. Among newer antipsychotic medicines, more likely to cause side effects, especially weight gain and hormone problems.Helps control your thoughts and mood. Seroquel (Quetiapine) is good for treating psychosis and mania. Fewer side effects than most antipsychotics, but might be less effective for people over age 40 with schizophrenia.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.448275862068965Risperdal
Reviews for Risperdal (Risperidone)
48%
of people say Risperdal (Risperidone) is worth it
41%
say it works well
48%
say it's a big hassle
Reviews for Seroquel (Quetiapine)
52%
+4% vs. Risperdal (Risperidone)
46%
+5% vs. Risperdal (Risperidone)
28%
+20% vs. Risperdal (Risperidone)
Side effects
RisperdalSeroquel
  • Relaxation or sleepiness 48%
  • Increased appetite 29%
  • Fatigue 22%
  • Parkinsonism 17%
  • Constipation 11%
  • Dizziness 11%
  • Abdominal pain upper 11%
  • Common cold 10%
  • Nausea 9%
  • Indigestion 8%
More Risperdal side effects »
  • Drowsiness 42%
  • Dry mouth 31%
  • Dizziness 17%
  • Fatigue 10%
  • Increased appetite 9%
  • Headache 7%
  • Nausea 6%
  • Constipation 6%
  • Muscle weakness 6%
  • Positional low blood pressure 5%
More Seroquel side effects »
How it works
RisperdalSeroquel
Risperdal (Risperidone) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Seroquel (Quetiapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.
Type of medication
RisperdalSeroquel
Antipsychotic
Atypical
Prescription only
Antipsychotic
Atypical
Prescription only
Available as
RisperdalSeroquel
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
  • Pill
  • Extended release
Used for (click to learn more)
RisperdalSeroquel
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Risperdal (Risperidone)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Seroquel (Quetiapine)
Risk factors for serious side effects
RisperdalSeroquel
  • Elderly patients with dementia
      • History of heart problems
      • Drug interactions
        • People with diabetes
        • People with high cholesterol
        • People with diabetes
        • Alcohol
        • Taking other medicines that make you less alert
          Detailed Risperdal (Risperidone) risks & warnings »
          • Elderly patients with dementia
              • History of heart problems
              • Drug interactions
                • People with diabetes
                • People with high cholesterol
                • People with diabetes
                • Alcohol
                • Taking other medicines that make you less alert
                  Detailed Seroquel (Quetiapine) risks & warnings »
                  Pregnancy category
                  RisperdalSeroquel
                  CFDA pregnancy category (Weigh risks vs. benefits)

                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  See the FDA package insert
                  CFDA pregnancy category (Weigh risks vs. benefits)

                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  See the FDA package insert
                  Alcohol
                  No specific alcohol-related info.No specific alcohol-related info.
                  Food
                  • Risperdal (Risperidone) can increase your blood sugar and cholesterol. Exercise and eat healthy food to lower your risk.
                  • Risperdal (Risperidone) can cause you to gain weight. Exercise and eat healthy food to lower your risk.
                  • Seroquel (Quetiapine) can increase your blood sugar and cholesterol. Seroquel (Quetiapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  Kidneys and liver
                  No specific kidneys and liver-related info.No specific kidneys and liver-related info.
                  Sex
                  No specific sex-related info.No specific sex-related info.
                  Sleep
                  • Can cause dizziness and drowsiness.
                  • Can cause dizziness, drowsiness, and low blood pressure.
                  Weight
                  • Moderate risk of weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
                  • May cause weight gain and worsen cholesterol or blood sugar.
                  • Risperdal (Risperidone) can cause you to gain weight. Exercise and eat healthy food to lower your risk.
                  • Sometimes causes weight gain, sleepiness, and low blood pressure.
                  • May cause weight gain and worsen cholesterol or blood sugar.
                  • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  Upsides and benefits
                  RisperdalSeroquel
                  • Effective at relieving psychotic symptoms, manic episodes, irritability, and aggressive behavior.
                  • Lowers relapse rates in people with schizophrenia and people with irritability associated with autism.
                  • Less likely to cause heart problems than some antipsychotics.
                  • Antipsychotic medicines are all about equally effective.
                  • Effective at relieving psychotic symptoms and manic episodes.
                  • Fewer side effects than most antipsychotic medicines.
                  • Less likely to cause heart problems compared to some antipsychotics.
                  • Compared to other antipsychotics, the least likely to cause Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
                  • Antipsychotic medicines are all about equally effective.
                  Downsides and risks
                  RisperdalSeroquel
                  • Mild to moderate risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
                  • Moderate risk of weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
                  • Compared to other antipsychotics, higher risk of hormone problems that cause nipples to leak and male breasts to grow abnormally large.
                  • You might need routine blood tests to check how the medicine is affecting your body.
                  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
                  • In studies, less effective for people over age 40 for schizophrenia.
                  • Sometimes causes weight gain, sleepiness, and low blood pressure.
                  • You might need routine blood tests to check how the medicine is affecting your body.
                  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
                  Tips from our pharmacists for people taking the medication
                  RisperdalSeroquel
                  • Can cause dizziness and drowsiness.
                  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
                  • For the first week, avoid activities that require you to be alert.
                  • May cause weight gain and worsen cholesterol or blood sugar.
                  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
                  • Elderly people with dementia shouldn't take it.
                  • Can cause dizziness, drowsiness, and low blood pressure.
                  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
                  • For the first week, avoid activities that require you to be alert.
                  • May cause weight gain and worsen cholesterol or blood sugar.
                  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
                  • Elderly people with dementia shouldn't take it.
                  Learn more
                  More about RisperdalSide effectsReviews & ratingsAlternativesFDA package insert
                  More about SeroquelSide effectsReviews & ratingsAlternativesFDA package insert