Compare Risperdal vs. Zyprexa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Risperdal
(Risperidone)

Zyprexa
(olanzapine)

Helps control your thoughts and mood. Risperdal (Risperidone) is good for treating psychosis, mania, and irritability. Among newer antipsychotic medicines, more likely to cause side effects, especially weight gain and hormone problems.Helps control your thoughts and mood. Zyprexa (olanzapine) is good for treating psychosis, mania, and agitation, but it's more likely to cause weight gain and sleepiness than other antipsychotics.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.53Risperdal
Reviews for Risperdal
42%
of people (All ages) say Risperdal is worth it
47%
say it works well
49%
say it's a big hassle
Have you used Risperdal (Risperidone)?
Worth itNot sureNot worth it
Reviews for Zyprexa
41%
+1% better vs. Risperdal
51%
-4% worse vs. Risperdal
51%
+2% better vs. Risperdal
Have you used Zyprexa (olanzapine)?
Worth itNot sureNot worth it
Side effects
RisperdalZyprexa
  • Vision blurred 1%
  • Stomach discomfort 2%
  • Fatigue 1%
  • Lethargy 1%
  • Diarrhea 1%
  • Salivary hypersecretion 2%
  • Nausea 3%
  • Dystonia 4%
  • Tremor 3%
  • Dizziness 1%
More Risperdal side effects »
  • Feeling dizzy/faint when standing up 3%
  • Akathisia (can't sit still) 4%
  • Weight gain 5%
  • Personality disorder 4%
  • Constipation 6%
  • Dizziness 7%
  • Increased appetite 3%
  • Tremor 3%
  • Stomach problems 6%
  • Weakness 9%
More Zyprexa side effects »
How it works
RisperdalZyprexa
Risperdal (Risperidone) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Zyprexa (olanzapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change chemical activity (like dopamine and serotonin) in your brain, which affects thoughts and mood.
Type of medication
RisperdalZyprexa
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
RisperdalZyprexa
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
  • Pill
  • Dissolving tablet
  • Injection
Used for
RisperdalZyprexa
Risk factors for serious side effects
RisperdalZyprexa
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Risperdal (Risperidone) risks & warnings »
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Zyprexa (olanzapine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
RisperdalZyprexa
  • Risperdal (Risperidone) can increase your blood sugar and cholesterol. Exercise and eat healthy food to lower your risk.
No food related info.
Sleep
RisperdalZyprexa
  • Can cause dizziness and drowsiness.
  • Can cause dizziness and drowsiness.
  • Might make you more sleepy than some antipsychotics.
Weight
RisperdalZyprexa
  • Risperdal (Risperidone) can cause you to gain weight. Exercise and eat healthy food to lower your risk.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Moderate risk of weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
  • Zyprexa (olanzapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Zyprexa (olanzapine) can also cause you to gain weight. Exercise and eat healthy food to lower your risk.
  • May cause weight gain and increased cholesterol or blood sugar.
  • More likely to cause weight gain and increase cholesterol or blood sugar compared to other antipsychotics.
Upsides and benefits
RisperdalZyprexa
  • Effective at relieving psychotic symptoms, manic episodes, irritability, and aggressive behavior.
  • Lowers relapse rates in people with schizophrenia and people with irritability associated with autism.
  • Antipsychotic medicines are all about equally effective.
  • Less likely to cause heart problems than some antipsychotics.
  • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
  • Less likely to cause heart problems than other antipsychotics.
  • Less likely to cause movement problems compared to older antipsychotics.
Downsides and risks
RisperdalZyprexa
  • Mild to moderate risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • Moderate risk of weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
  • Compared to other antipsychotics, higher risk of hormone problems that cause nipples to leak and male breasts to grow abnormally large.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
  • More likely to cause weight gain and increase cholesterol or blood sugar compared to other antipsychotics.
  • Might make you more sleepy than some antipsychotics.
  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive movements you can't control.
  • You may need routine blood tests to check how the medicine is affecting your body..
Tips from our pharmacists for people taking the medication
RisperdalZyprexa
  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
  • Can cause dizziness and drowsiness.
  • For the first week, avoid activities that require you to be alert.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take it.
  • Takes at least 4 to 6 weeks to see full effects on thoughts and mood.
  • Can cause dizziness and drowsiness.
  • For the first week, avoid activities that require you to be alert.
  • May cause weight gain and increased cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take Zyprexa (olanzapine).
Learn more
More about RisperdalSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Risperdal (Risperidone)?
Worth itNot sureNot worth it
More about ZyprexaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zyprexa (olanzapine)?
Worth itNot sureNot worth it