Compare Robaxin vs. baclofen

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Robaxin (methocarbamol)

Prescription only

Lioresal (baclofen)

Prescription only
Relaxes your muscles.

Robaxin (methocarbamol) effectively relieves muscle spasms, but it can cause drowsiness and interfere with your ability to drive.

Relaxes your muscles.

Lioresal (baclofen) is a first choice treatment for muscle spasticity caused by multiple sclerosis or spinal cord injuries, but it's not recommended for other types of muscle spasms.

3.5/ 5 average rating with 33 reviewsforbaclofen
Upsides
  • Effective for relieving muscle spasms and pain.
  • For those with trouble swallowing, the pills can be crushed and mixed with food or liquid.
  • Available in generic form and cheaper than other muscle relaxants.
  • Might be a better treatment option for those with a history of drug abuse since Robaxin (methocarbamol) has a low potential for causing addiction and dependence.
  • A better option for seniors compared to other muscle relaxants since it has fewer side effects than other similar medicines.
  • Lioresal (baclofen) is available as a generic and is a relatively inexpensive medication.
Downsides
  • Robaxin (methocarbamol) can make you sleepy so you might not be able to drive or do certain activities requiring concentration.
  • Need to take a few times throughout the day to maintain effect.
  • Might not be safe to use in people age 65 or older due to increased sensitivity to side effects such as drowsiness.
  • Researches do not know the safety and effectiveness of Robaxin (methocarbamol) in people under age 16.
  • Can be dangerous when used together with other medicines that also cause drowsiness such as narcotics.
  • Except for specific muscle spasms caused by brain injury or multiple sclerosis, Lioresal (baclofen) is not a recommended medicine.
  • If you've been taking Lioresal (baclofen) regularly for a long time, you'll need to get off of it slowly.
  • Lioresal (baclofen) can make you sleepy.
  • If you've had a stroke, Lioresal (baclofen) may not work as well, and you're more likely to experience side effects.
Used for
Dosage forms
  • Pill
  • Pill
Price
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Reviews
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33 reviews so far
61%
saidit'sworth it
55%
saiditworked well
15%
saidit'sa big hassle

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Side effects
The Robaxin (methocarbamol) FDA package insert doesn’t have numbers about how common side effects are.
1possible side effects
  • Drowsiness
    63%
See more detailed side effects
Risks and risk factors
  • Drowsiness
    • Taking other medicines that also cause drowsiness
    • Drinking alcohol
    • People age 65 or older
  • Harm to fetus (unborn baby)
    • Women who want to or can become pregnant
    • Pregnant women
See more detailed risks and warnings
  • Withdrawal symptoms
    • Stopping Lioresal (baclofen) too quickly
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
  • Seizures
    • Higher dose
    • Using other medicines that can cause seizures
    • History of seizures
    • Alcoholism
    • Eating disorders
    • Brain infections
See more detailed risks and warnings