Compare Robitussin Multi-Symptom Cold CF vs. Delsym

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relieves cold symptoms.

Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) is okay for loosening congestion in your throat and sinuses, but it could prevent you from coughing the mucus up.

Relieves coughing.

Delsym (Dextromethorphan) is a good option for treating dry cough. It's not safe to take with MAO inhibitors though.

3.3/ 5 average rating with 127 reviewsforDelsym
Upsides
  • Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, congestion, and a cough.
  • Helps loosen the mucus and phlegm that builds up in productive and wet coughs.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Good for treating dry cough.
  • Available in drugstores either by itself or in combination with other medications to treat cold and allergy symptoms.
  • Available as a liquid and a tablet.
  • Some products relieve cough for up to 12 hours.
Downsides
  • Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) isn’t useful if you have a dry cough without mucus or phlegm.
  • Two of the medications in this product could potentially work against each other. Guaifenesin makes mucus easier to cough up, while dextromethorphan stops you from coughing.
  • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • Can't take dextromethorphan if you're taking MAO inhibitors (drugs used to treat Parkinson's disease, depression, and other emotional conditions). If taken together, they will cause dangerously high blood pressure levels.
  • If you're taking this in combination with other cold and allergy medications, you should read labels closely to make sure you're not accidentally taking too much of a single ingredient.
Used for
Dosage forms
  • Liquid
  • Pill
  • Liquid extended release
No pricing information available
No pricing information available
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Reviews
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127 reviews so far
63%
saidit'sworth it
32%
saiditworked well
12%
saidit'sa big hassle

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Side effects
The Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) FDA package insert doesn’t have numbers about how common side effects are.
The Delsym (Dextromethorphan) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Serotonin syndrome
    • Using other medications that affect serotonin
  • High blood pressure
    • History of high blood pressure
    • Taking MAO inhibitors
  • Cough warning
  • Harm to unborn babies
    • Women of childbearing age
See more detailed risks and warnings
  • Serotonin syndrome
    • Using other medications that affect serotonin
See more detailed risks and warnings