Compare Robitussin Multi-Symptom Cold CF vs. Mucinex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Robitussin Multi-Symptom Cold Cf
(dextromethorphan / guaifenesin / phenylephrine)

Mucinex
(guaifenesin)

Relieves cold symptoms. Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) is okay for loosening congestion in your throat and sinuses, but it could prevent you from coughing the mucus up.Breaks up mucus that causes cough. Mucinex (Guaifenesin) is a useful medicine for loosening congestion in your chest and throat, and it lasts longer than other guaifenesin products.
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Reviews & ratings
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Reviews for Robitussin Multi-Symptom Cold Cf (dextromethorphan / guaifenesin / phenylephrine)
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of people (All ages) say Robitussin Multi-Symptom Cold Cf (dextromethorphan / guaifenesin / phenylephrine) is worth it
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say it works well
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say it's a big hassle
Have you used Robitussin Multi-Symptom Cold Cf (dextromethorphan / guaifenesin / phenylephrine)?
Worth itNot sureNot worth it
Reviews for Mucinex (guaifenesin)
78%
-22% worse vs. Robitussin Multi-Symptom Cold Cf (dextromethorphan / guaifenesin / phenylephrine)
47%
-53% worse vs. Robitussin Multi-Symptom Cold Cf (dextromethorphan / guaifenesin / phenylephrine)
7%
-7% worse vs. Robitussin Multi-Symptom Cold Cf (dextromethorphan / guaifenesin / phenylephrine)
902 reviews
Have you used Mucinex (guaifenesin)?
Worth itNot sureNot worth it
Side effects
Robitussin Multi-Symptom Cold CFMucinex

We haven’t found good data for Robitussin Multi-Symptom Cold CF side effects.

FDA side effect reports for Robitussin Multi-Symptom Cold CF »

We haven’t found good data for Mucinex side effects.

FDA side effect reports for Mucinex »
How it works
Robitussin Multi-Symptom Cold CFMucinex
Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) is a combination medicine that treats cold symptoms. Guaifenesin breaks up mucus and phlegm. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Mucinex (Guaifenesin) is an expectorant. It contains guaifenesin, which thins and loosens mucus, making it easier to cough out.
Type of medication
Robitussin Multi-Symptom Cold CFMucinex
Over-the-counter
Over-the-counter
Available as
Robitussin Multi-Symptom Cold CFMucinex
  • Liquid
  • Extended release
  • Liquid
Used for
Robitussin Multi-Symptom Cold CFMucinex
Risk factors for serious side effects
Robitussin Multi-Symptom Cold CFMucinex
  • Using other medications that affect serotonin
  • History of high blood pressure
  • Taking MAO inhibitors
  • Women of childbearing age
Detailed Robitussin Multi-Symptom Cold Cf (dextromethorphan / guaifenesin / phenylephrine) risks & warnings »
    Detailed Mucinex (guaifenesin) risks & warnings »
    Pregnancy

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Alcohol
    Robitussin Multi-Symptom Cold CFMucinex
    No alcohol related info.
    • Mucinex (Guaifenesin) is alcohol- and sugar-free.
    Upsides and benefits
    Robitussin Multi-Symptom Cold CFMucinex
    • Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, congestion, and a cough.
    • Helps loosen the mucus and phlegm that builds up in productive and wet coughs.
    • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
    • Mucinex (Guaifenesin) reduces the thickness and amount of mucus in your throat and chest.
    • Lasts longer than some other products that contain guaifenesin, such as Robitussin, because it's an extended-release form.
    • It’s available at the drugstore either by itself or in combination with other medications to treat cold and flu symptoms.
    • Available in liquid and tablet forms.
    • Mucinex (Guaifenesin) is alcohol- and sugar-free.
    Downsides and risks
    Robitussin Multi-Symptom Cold CFMucinex
    • Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) isn’t useful if you have a dry cough without mucus or phlegm.
    • Two of the medications in this product could potentially work against each other. Guaifenesin makes mucus easier to cough up, while dextromethorphan stops you from coughing.
    • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
    • You shouldn't use it if you have high blood pressure.
    • Mucinex (Guaifenesin) is more expensive than other medications that treat congestion.
    • You need to drink a lot of fluids while taking this medication or it won't work as well.
    • Mucinex (Guaifenesin) isn’t useful if you have a dry cough.
    • Can cause nausea, headache, and an upset stomach.
    Tips from our pharmacists for people taking the medication
    Robitussin Multi-Symptom Cold CFMucinex
    • Cough suppressant starts working in 15 to 30 minutes.
    • Drink plenty of fluids while taking Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) because liquid helps break down mucus.
    • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
    • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
    • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
    • Drink plenty of fluids while taking Mucinex (Guaifenesin) because liquid helps break down mucus.
    • Steam from a humidifier, cool mist vaporizer, or hot shower can also help add moisture to your airways.
    • Follow age-specific dosing instructions on how much to take.
    • If your cough lasts more than 7 days, call your doctor.
    • Mucinex (Guaifenesin) only works for coughs with mucus, so don't use it if you have a dry cough.
    Learn more
    More about Robitussin Multi-Symptom Cold CFSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Robitussin Multi-Symptom Cold Cf (dextromethorphan / guaifenesin / phenylephrine)?
    Worth itNot sureNot worth it
    More about MucinexSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Mucinex (guaifenesin)?
    Worth itNot sureNot worth it