Compare Robitussin Multi-Symptom Cold CF vs. Mucinex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relieves cold symptoms.

Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) is okay for loosening congestion in your throat and sinuses, but it could prevent you from coughing the mucus up.

Breaks up mucus that causes cough.

Mucinex (Guaifenesin) is a useful medicine for loosening congestion in your chest and throat, and it lasts longer than other guaifenesin products.

3.8/ 5 average rating with 902 reviewsforMucinex
Upsides
  • Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, congestion, and a cough.
  • Helps loosen the mucus and phlegm that builds up in productive and wet coughs.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Mucinex (Guaifenesin) reduces the thickness and amount of mucus in your throat and chest.
  • Lasts longer than some other products that contain guaifenesin, such as Robitussin, because it's an extended-release form.
  • It’s available at the drugstore either by itself or in combination with other medications to treat cold and flu symptoms.
  • Available in liquid and tablet forms.
  • Mucinex (Guaifenesin) is alcohol- and sugar-free.
Downsides
  • Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) isn’t useful if you have a dry cough without mucus or phlegm.
  • Two of the medications in this product could potentially work against each other. Guaifenesin makes mucus easier to cough up, while dextromethorphan stops you from coughing.
  • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • Mucinex (Guaifenesin) is more expensive than other medications that treat congestion.
  • You need to drink a lot of fluids while taking this medication or it won't work as well.
  • Mucinex (Guaifenesin) isn’t useful if you have a dry cough.
  • Can cause nausea, headache, and an upset stomach.
Used for
Dosage forms
  • Liquid
  • Extended release
  • Liquid
No pricing information available
No pricing information available
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Reviews
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902 reviews so far
78%
saidit'sworth it
47%
saiditworked well
7%
saidit'sa big hassle

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Side effects
The Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) FDA package insert doesn’t have numbers about how common side effects are.
The Mucinex (Guaifenesin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Serotonin syndrome
    • Using other medications that affect serotonin
  • High blood pressure
    • History of high blood pressure
    • Taking MAO inhibitors
  • Cough warning
  • Harm to unborn babies
    • Women of childbearing age
See more detailed risks and warnings