Compare Robitussin Multi-Symptom Cold CF vs. Mucinex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Robitussin Multi-Symptom Cold Cf
(Dextromethorphan / Guaifenesin / Phenylephrine)

Mucinex
(Guaifenesin)

Relieves cold symptoms. Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) is okay for loosening congestion in your throat and sinuses, but it could prevent you from coughing the mucus up.Breaks up mucus that causes cough. Mucinex (Guaifenesin) is a useful medicine for loosening congestion in your chest and throat, and it lasts longer than other guaifenesin products.
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Reviews & ratings
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Reviews for Mucinex (Guaifenesin)
78%
22% vs. Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine)
47%
53% vs. Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine)
7%
7% vs. Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine)
Side effects
Robitussin Multi-Symptom Cold CFMucinex

We haven’t found good data for Robitussin Multi-Symptom Cold CF side effects.

FDA side effect reports for Robitussin Multi-Symptom Cold CF »

We haven’t found good data for Mucinex side effects.

FDA side effect reports for Mucinex »
How it works
Robitussin Multi-Symptom Cold CFMucinex
Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) is a combination medicine that treats cold symptoms. Guaifenesin breaks up mucus and phlegm. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Mucinex (Guaifenesin) is an expectorant. It contains guaifenesin, which thins and loosens mucus, making it easier to cough out.
Type of medication
Robitussin Multi-Symptom Cold CFMucinex
Cough suppressantExpectorantDecongestantOver-the-counter
ExpectorantOver-the-counter
Available as
Robitussin Multi-Symptom Cold CFMucinex
  • Liquid
  • Extended release
  • Liquid
Used for (click to learn more)
Robitussin Multi-Symptom Cold CFMucinex
Risk factors for serious side effects
Robitussin Multi-Symptom Cold CFMucinex
  • Using other medications that affect serotonin
  • History of high blood pressure
  • Taking MAO inhibitors
    • Women of childbearing age
    Detailed Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) risks & warnings »
      Detailed Mucinex (Guaifenesin) risks & warnings »
      Pregnancy category
      Robitussin Multi-Symptom Cold CFMucinex
      NFDA pregnancy category (Unknown)

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      See the FDA package insert
      NFDA pregnancy category (Unknown)

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.
      • Mucinex (Guaifenesin) is alcohol- and sugar-free.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      Robitussin Multi-Symptom Cold CFMucinex
      • Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, congestion, and a cough.
      • Helps loosen the mucus and phlegm that builds up in productive and wet coughs.
      • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
      • Mucinex (Guaifenesin) reduces the thickness and amount of mucus in your throat and chest.
      • Lasts longer than some other products that contain guaifenesin, such as Robitussin, because it's an extended-release form.
      • It’s available at the drugstore either by itself or in combination with other medications to treat cold and flu symptoms.
      • Available in liquid and tablet forms.
      • Mucinex (Guaifenesin) is alcohol- and sugar-free.
      Downsides and risks
      Robitussin Multi-Symptom Cold CFMucinex
      • Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) isn’t useful if you have a dry cough without mucus or phlegm.
      • Two of the medications in this product could potentially work against each other. Guaifenesin makes mucus easier to cough up, while dextromethorphan stops you from coughing.
      • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
      • You shouldn't use it if you have high blood pressure.
      • Mucinex (Guaifenesin) is more expensive than other medications that treat congestion.
      • You need to drink a lot of fluids while taking this medication or it won't work as well.
      • Mucinex (Guaifenesin) isn’t useful if you have a dry cough.
      • Can cause nausea, headache, and an upset stomach.
      Tips from our pharmacists for people taking the medication
      Robitussin Multi-Symptom Cold CFMucinex
      • Cough suppressant starts working in 15 to 30 minutes.
      • Drink plenty of fluids while taking Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) because liquid helps break down mucus.
      • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
      • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
      • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
      • Drink plenty of fluids while taking Mucinex (Guaifenesin) because liquid helps break down mucus.
      • Steam from a humidifier, cool mist vaporizer, or hot shower can also help add moisture to your airways.
      • Follow age-specific dosing instructions on how much to take.
      • If your cough lasts more than 7 days, call your doctor.
      • Mucinex (Guaifenesin) only works for coughs with mucus, so don't use it if you have a dry cough.
      Learn more
      More about Robitussin Multi-Symptom Cold CFSide effectsReviews & ratingsAlternativesFDA package insert
      More about MucinexSide effectsReviews & ratingsAlternativesFDA package insert