Compare Robitussin Multi-Symptom Cold CF vs. Mucinex D

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Robitussin Multi-Symptom Cold Cf
(Dextromethorphan / Guaifenesin / Phenylephrine)

Mucinex D
(Guaifenesin / Pseudoephedrine)

Relieves cold symptoms. Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) is okay for loosening congestion in your throat and sinuses, but it could prevent you from coughing the mucus up.Breaks up mucus and relieves congestion. Mucinex D (Guaifenesin / Pseudoephedrine) is good if you have a stuffy nose and a cough with mucus, but it could keep you up at night.
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Reviews & ratings
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Reviews for Mucinex D (Guaifenesin / Pseudoephedrine)
76%
24% vs. Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine)
41%
59% vs. Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine)
7%
7% vs. Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine)
Side effects
Robitussin Multi-Symptom Cold CFMucinex D

We haven’t found good data for Robitussin Multi-Symptom Cold CF side effects.

FDA side effect reports for Robitussin Multi-Symptom Cold CF »

We haven’t found good data for Mucinex D side effects.

FDA side effect reports for Mucinex D »
How it works
Robitussin Multi-Symptom Cold CFMucinex D
Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) is a combination medicine that treats cold symptoms. Guaifenesin breaks up mucus and phlegm. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine. Guaifenesin (an expectorant) breaks up and thins out mucus. Pseudoephedrine (a decongestant) clears your sinuses.
Type of medication
Robitussin Multi-Symptom Cold CFMucinex D
Cough suppressantExpectorantDecongestantOver-the-counter
ExpectorantDecongestantOver-the-counter
Available as
Robitussin Multi-Symptom Cold CFMucinex D
  • Liquid
  • Extended release
Used for (click to learn more)
Robitussin Multi-Symptom Cold CFMucinex D
Risk factors for serious side effects
Robitussin Multi-Symptom Cold CFMucinex D
  • Using other medications that affect serotonin
  • History of high blood pressure
  • Taking MAO inhibitors
    • Women of childbearing age
    Detailed Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) risks & warnings »
    • History of high blood pressure
    • History of heart problems
    • Age 65 years or older
      Detailed Mucinex D (Guaifenesin / Pseudoephedrine) risks & warnings »
      Pregnancy category
      Robitussin Multi-Symptom Cold CFMucinex D
      NFDA pregnancy category (Unknown)

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      See the FDA package insert
      NFDA pregnancy category (Unknown)

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      Robitussin Multi-Symptom Cold CFMucinex D
      • Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, congestion, and a cough.
      • Helps loosen the mucus and phlegm that builds up in productive and wet coughs.
      • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
      • Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have sinus and chest congestion.
      • Helps loosen the mucus in your airways so that you can cough it up more easily.
      • Works well to clear nasal congestion and help you breathe better.
      Downsides and risks
      Robitussin Multi-Symptom Cold CFMucinex D
      • Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) isn’t useful if you have a dry cough without mucus or phlegm.
      • Two of the medications in this product could potentially work against each other. Guaifenesin makes mucus easier to cough up, while dextromethorphan stops you from coughing.
      • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
      • You shouldn't use it if you have high blood pressure.
      • Pseudoephedrine, the decongestant in Mucinex D (Guaifenesin / Pseudoephedrine), can make your heart race or make you feel anxious and restless.
      • Doesn't work as well if you use it for more than 4 days at a time.
      • Although you don't need a prescription to get Mucinex D (Guaifenesin / Pseudoephedrine), you need to show a photo ID to buy it in the drugstore.
      • Mucinex D (Guaifenesin / Pseudoephedrine) isn’t useful if you have a dry cough.
      Tips from our pharmacists for people taking the medication
      Robitussin Multi-Symptom Cold CFMucinex D
      • Cough suppressant starts working in 15 to 30 minutes.
      • Drink plenty of fluids while taking Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) because liquid helps break down mucus.
      • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
      • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
      • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
      • Drink plenty of fluids while taking Mucinex D (Guaifenesin / Pseudoephedrine) because liquid helps break down mucus.
      • You need to show an ID to buy Mucinex D (Guaifenesin / Pseudoephedrine) in the drugstore because it contains pseudoephedrine.
      • Don't take Mucinex D (Guaifenesin / Pseudoephedrine) too close to bedtime since it can keep you awake.
      • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
      • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
      Learn more
      More about Robitussin Multi-Symptom Cold CFSide effectsReviews & ratingsAlternativesFDA package insert
      More about Mucinex DSide effectsReviews & ratingsAlternativesFDA package insert