Compare Robitussin Multi-Symptom Cold CF vs. Mucinex D

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine)

Over-the-counter
Relieves cold symptoms.

Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) is okay for loosening congestion in your throat and sinuses, but it could prevent you from coughing the mucus up.

Breaks up mucus and relieves congestion.

Mucinex D (Guaifenesin / Pseudoephedrine) is good if you have a stuffy nose and a cough with mucus, but it could keep you up at night.

5.2/ 7 average rating with 1249 reviewsforMucinex D
Upsides
  • Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, congestion, and a cough.
  • Helps loosen the mucus and phlegm that builds up in productive and wet coughs.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have sinus and chest congestion.
  • Helps loosen the mucus in your airways so that you can cough it up more easily.
  • Works well to clear nasal congestion and help you breathe better.
Downsides
  • Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) isn’t useful if you have a dry cough without mucus or phlegm.
  • Two of the medications in this product could potentially work against each other. Guaifenesin makes mucus easier to cough up, while dextromethorphan stops you from coughing.
  • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • Pseudoephedrine, the decongestant in Mucinex D (Guaifenesin / Pseudoephedrine), can make your heart race or make you feel anxious and restless.
  • Doesn't work as well if you use it for more than 4 days at a time.
  • Although you don't need a prescription to get Mucinex D (Guaifenesin / Pseudoephedrine), you need to show a photo ID to buy it in the drugstore.
  • Mucinex D (Guaifenesin / Pseudoephedrine) isn’t useful if you have a dry cough.
Used for
Dosage forms
  • Liquid
  • Extended release
No pricing information available
No pricing information available
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Reviews
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1249 
76%
think this treatment is worth it
41%
think this treatment works well
7%
think this treatment is a hassle

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Side effects
The Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) FDA package insert doesn’t have numbers about how common side effects are.
The Mucinex D (Guaifenesin / Pseudoephedrine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Serotonin syndrome

    Using other medications that affect serotonin

  • High blood pressure

    History of high blood pressure

    ...and 1 more risk factors

  • Harm to unborn babies

    Women of childbearing age

See more detailed risks and warnings
  • High blood pressure

    History of high blood pressure

  • Heart problems

    History of heart problems

    ...and 1 more risk factors

See more detailed risks and warnings