Compare Robitussin Multi-Symptom Cold CF vs. Mucinex DM

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Robitussin Multi-Symptom Cold Cf
(Dextromethorphan / Guaifenesin / Phenylephrine)

Mucinex Dm
(Dextromethorphan / Guaifenesin)

Relieves cold symptoms. Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) is okay for loosening congestion in your throat and sinuses, but it could prevent you from coughing the mucus up.Breaks up mucus and relieves cough. Mucinex Dm (Dextromethorphan / Guaifenesin) is okay for loosening congestion in your chest and throat, but it could prevent you from coughing the mucus up. It comes as an extended-release tablet and a short-acting liquid.
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Side effects
Robitussin Multi-Symptom Cold CFMucinex DM

We haven’t found good data for Robitussin Multi-Symptom Cold CF side effects.

FDA side effect reports for Robitussin Multi-Symptom Cold CF »

We haven’t found good data for Mucinex DM side effects.

FDA side effect reports for Mucinex DM »
How it works
Robitussin Multi-Symptom Cold CFMucinex DM
Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) is a combination medicine that treats cold symptoms. Guaifenesin breaks up mucus and phlegm. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Mucinex Dm (Dextromethorphan / Guaifenesin) is a combination medicine. Guaifenesin is an expectorant that breaks up and thins out mucus. Dextromethorphan is a cough suppressant.
Type of medication
Robitussin Multi-Symptom Cold CFMucinex DM
Cough suppressantExpectorantDecongestantOver-the-counter
Cough suppressantExpectorantOver-the-counter
Available as
Robitussin Multi-Symptom Cold CFMucinex DM
  • Liquid
  • Pill
  • Extended release
  • Liquid
Used for (click to learn more)
Robitussin Multi-Symptom Cold CFMucinex DM
Risk factors for serious side effects
Robitussin Multi-Symptom Cold CFMucinex DM
  • Using other medications that affect serotonin
  • History of high blood pressure
  • Taking MAO inhibitors
    • Women of childbearing age
    Detailed Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) risks & warnings »
      • Using other medications that affect serotonin
        Detailed Mucinex Dm (Dextromethorphan / Guaifenesin) risks & warnings »
        Pregnancy category
        Robitussin Multi-Symptom Cold CFMucinex DM
        NFDA pregnancy category (Unknown)

        The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

        See the FDA package insert
        NFDA pregnancy category (Unknown)

        The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.No specific alcohol-related info.
        Food
        No specific food-related info.No specific food-related info.
        Kidneys and liver
        No specific kidneys and liver-related info.No specific kidneys and liver-related info.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.
        Weight
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        Robitussin Multi-Symptom Cold CFMucinex DM
        • Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, congestion, and a cough.
        • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
        • Helps loosen the mucus and phlegm that builds up in productive and wet coughs.
        • Mucinex Dm (Dextromethorphan / Guaifenesin) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have chest congestion and a cough.
        • The extended release version of Mucinex DM lasts up to 12 hours.
        • Helps loosen the mucus and phlegm that builds up in productive and wet coughs.
        Downsides and risks
        Robitussin Multi-Symptom Cold CFMucinex DM
        • Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) isn’t useful if you have a dry cough without mucus or phlegm.
        • Two of the medications in this product could potentially work against each other. Guaifenesin makes mucus easier to cough up, while dextromethorphan stops you from coughing.
        • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
        • You shouldn't use it if you have high blood pressure.
        • Mucinex Dm (Dextromethorphan / Guaifenesin) isn’t useful if you have a dry cough without mucus or phlegm.
        • The two medications in this product could potentially work against each other. Guaifenesin makes mucus easier to cough up, while dextromethorphan (the "DM" in Mucinex Dm (Dextromethorphan / Guaifenesin)) stops you from coughing.
        • Can cause sleepiness, dizziness, and an upset stomach.
        Tips from our pharmacists for people taking the medication
        Robitussin Multi-Symptom Cold CFMucinex DM
        • Drink plenty of fluids while taking Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) because liquid helps break down mucus.
        • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
        • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
        • Cough suppressant starts working in 15 to 30 minutes.
        • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
        • Drink plenty of fluids while taking Mucinex Dm (Dextromethorphan / Guaifenesin) because liquid helps break down mucus.
        • If your cough lasts more than 7 days, call your doctor.
        • Cough suppressant starts working in 15 to 30 minutes.
        • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
        Learn more
        More about Robitussin Multi-Symptom Cold CFSide effectsReviews & ratingsAlternativesFDA package insert
        More about Mucinex DMSide effectsReviews & ratingsAlternativesFDA package insert