Compare Robitussin Multi-Symptom Cold CF vs. Robitussin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine)

Over-the-counter

Robitussin (Guaifenesin)

Over-the-counter
Relieves cold symptoms.

Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) is okay for loosening congestion in your throat and sinuses, but it could prevent you from coughing the mucus up.

Breaks up mucus that causes cough.

Robitussin (Guaifenesin) is a useful medicine for loosening congestion in your chest and throat, but it doesn't last as long as other guaifenesin products.

Upsides
  • Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, congestion, and a cough.
  • Helps loosen the mucus and phlegm that builds up in productive and wet coughs.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Robitussin (Guaifenesin) reduces the thickness and amount of mucus in your throat and chest.
  • It’s available at the drugstore either by itself or in combination with other medications to treat cold and flu symptoms.
  • Available in multiple forms.
  • Can be used in children 12 years and older.
Downsides
  • Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) isn’t useful if you have a dry cough without mucus or phlegm.
  • Two of the medications in this product could potentially work against each other. Guaifenesin makes mucus easier to cough up, while dextromethorphan stops you from coughing.
  • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • Robitussin (Guaifenesin) doesn't last as long as other products that contain guaifenesin. Mucinex's extended release form lasts 12 hours and Robitussin (Guaifenesin)'s lasts 8 hours.
  • You need to drink a lot of fluids while taking this medication or it won't work as well.
  • Robitussin (Guaifenesin) isn’t useful if you have a dry cough.
  • Can cause nausea, headache, and an upset stomach.
Used for
Dosage forms
  • Liquid
  • Liquid
No pricing information available
No pricing information available
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Reviews
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Side effects
The Robitussin Multi-Symptom Cold Cf (Dextromethorphan / Guaifenesin / Phenylephrine) FDA package insert doesn’t have numbers about how common side effects are.
The Robitussin (Guaifenesin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Serotonin syndrome

    Using other medications that affect serotonin

  • High blood pressure

    History of high blood pressure

    ...and 1 more risk factors

  • Harm to unborn babies

    Women of childbearing age

See more detailed risks and warnings