Compare Robitussin vs. Mucinex D

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Robitussin
(Guaifenesin)

Mucinex D
(Guaifenesin / Pseudoephedrine)

Breaks up mucus that causes cough. Robitussin (Guaifenesin) is a useful medicine for loosening congestion in your chest and throat, but it doesn't last as long as other guaifenesin products.Breaks up mucus and relieves congestion. Mucinex D (Guaifenesin / Pseudoephedrine) is good if you have a stuffy nose and a cough with mucus, but it could keep you up at night.
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Reviews & ratings
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Reviews for Mucinex D (Guaifenesin / Pseudoephedrine)
76%
24% vs. Robitussin (Guaifenesin)
41%
+1% vs. Robitussin (Guaifenesin)
7%
7% vs. Robitussin (Guaifenesin)
Side effects
RobitussinMucinex D

We haven’t found good data for Robitussin side effects.

FDA side effect reports for Robitussin »

We haven’t found good data for Mucinex D side effects.

FDA side effect reports for Mucinex D »
How it works
RobitussinMucinex D
Robitussin (Guaifenesin) is an expectorant. It contains guaifenesin, which thins and loosens mucus, making it easier to cough out.Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine. Guaifenesin (an expectorant) breaks up and thins out mucus. Pseudoephedrine (a decongestant) clears your sinuses.
Type of medication
RobitussinMucinex D
ExpectorantOver-the-counter
ExpectorantDecongestantOver-the-counter
Available as
RobitussinMucinex D
  • Liquid
  • Extended release
Used for (click to learn more)
RobitussinMucinex D
Risk factors for serious side effects
RobitussinMucinex D
    Detailed Robitussin (Guaifenesin) risks & warnings »
    • History of high blood pressure
    • History of heart problems
    • Age 65 years or older
      Detailed Mucinex D (Guaifenesin / Pseudoephedrine) risks & warnings »
      Pregnancy category
      RobitussinMucinex D
      NFDA pregnancy category (Unknown)

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      See the FDA package insert
      NFDA pregnancy category (Unknown)

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      RobitussinMucinex D
      • Robitussin (Guaifenesin) reduces the thickness and amount of mucus in your throat and chest.
      • It’s available at the drugstore either by itself or in combination with other medications to treat cold and flu symptoms.
      • Available in multiple forms.
      • Can be used in children 12 years and older.
      • Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have sinus and chest congestion.
      • Helps loosen the mucus in your airways so that you can cough it up more easily.
      • Works well to clear nasal congestion and help you breathe better.
      Downsides and risks
      RobitussinMucinex D
      • Robitussin (Guaifenesin) doesn't last as long as other products that contain guaifenesin. Mucinex's extended release form lasts 12 hours and Robitussin (Guaifenesin)'s lasts 8 hours.
      • You need to drink a lot of fluids while taking this medication or it won't work as well.
      • Robitussin (Guaifenesin) isn’t useful if you have a dry cough.
      • Can cause nausea, headache, and an upset stomach.
      • Pseudoephedrine, the decongestant in Mucinex D (Guaifenesin / Pseudoephedrine), can make your heart race or make you feel anxious and restless.
      • Doesn't work as well if you use it for more than 4 days at a time.
      • Although you don't need a prescription to get Mucinex D (Guaifenesin / Pseudoephedrine), you need to show a photo ID to buy it in the drugstore.
      • Mucinex D (Guaifenesin / Pseudoephedrine) isn’t useful if you have a dry cough.
      Tips from our pharmacists for people taking the medication
      RobitussinMucinex D
      • Drink plenty of fluids while taking Robitussin (Guaifenesin) because liquid helps break down mucus.
      • Steam from a humidifier, cool mist vaporizer, or hot shower can also help add moisture to your airways.
      • Follow age-specific dosing instructions on how much to take.
      • If your cough lasts more than 7 days, call your doctor.
      • Robitussin (Guaifenesin) only works for coughs with mucus, so don't use it if you have a dry cough.
      • Drink plenty of fluids while taking Mucinex D (Guaifenesin / Pseudoephedrine) because liquid helps break down mucus.
      • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
      • You need to show an ID to buy Mucinex D (Guaifenesin / Pseudoephedrine) in the drugstore because it contains pseudoephedrine.
      • Don't take Mucinex D (Guaifenesin / Pseudoephedrine) too close to bedtime since it can keep you awake.
      • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
      Learn more
      More about RobitussinSide effectsReviews & ratingsAlternativesFDA package insert
      More about Mucinex DSide effectsReviews & ratingsAlternativesFDA package insert