Compare Rozerem vs. Doxepin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Rozerem
(ramelteon)

Zonalon
(doxepin)

Helps you fall asleep. Rozerem (ramelteon) is a good sleep medicine that's not addictive, but it can be expensive.Helps you stop itching. Zonalon (Doxepin) works well treating itchy skin, but could make you sleepy.
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Coupons for Rozerem
Best available price for 30 (8mg) tablets of rozerem
Coupons for Doxepin
Best available price for 30 (10mg) capsules of doxepin
Reviews & ratings
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Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Rozerem (ramelteon)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Zonalon (doxepin)?
Worth itNot sureNot worth it
Side effects
RozeremDoxepin
  • Dizziness 1%
  • Sleepiness 1%
  • Fatigue 1%
  • Nausea 1%
  • Worsening insomnia 1%
More Rozerem side effects »

We haven’t found good data for Doxepin side effects.

FDA side effect reports for Doxepin »
How it works
RozeremDoxepin
Rozerem (ramelteon) is a melatonin receptor agonist. Melatonin is a chemical the body uses to maintain a normal sleeping cycle; Rozerem (ramelteon) helps you fall asleep and stay asleep.Zonalon (Doxepin) is an cream that stops you from itching by blocking the chemical receptors that cause itching.
Type of medication
RozeremDoxepin
Prescription onlyPrescription only
Available as
RozeremDoxepin
  • Pill
  • Cream, gel, or ointment
Used for
RozeremDoxepin
  • Skin Intching Moderate
Risk factors for serious side effects
RozeremDoxepin
  • Alcohol
  • Taking narcotics, tranquilizers, or antihistamines
Detailed Rozerem (ramelteon) risks & warnings »
    Detailed Zonalon (doxepin) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Price
    RozeremDoxepin
    No price related info.
    • It isn't available as a generic, so it could be kind of pricey.
    Interactions
    RozeremDoxepin
    No interactions related info.
    • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
    Alcohol
    RozeremDoxepin
    • While taking Rozerem (ramelteon), don't drink alcohol or take other medicines that can make you sleepy, like opioids for pain relief, or benzodiazepines for anxiety.
    No alcohol related info.
    Pain
    RozeremDoxepin
    • If you’re taking Rozerem (ramelteon), you need to be very careful about drinking alcohol, or taking medicines such as narcotics for pain relief, tranquilizers for anxiety, or antihistamines. Taking Rozerem (ramelteon) with alcohol or these medicines can slow down your central nervous system to the point where you stop breathing. Talk to your doctor to see if you should change your other medicines while you take Rozerem (ramelteon).
    No pain related info.
    Sleep
    RozeremDoxepin
    • Don't take Rozerem (ramelteon) if you're not able to sleep for at least 8 hours.
    • If you're not sleeping better after taking Rozerem (ramelteon) for 7 to 10 days, talk to your doctor.
    • Zonalon (Doxepin) can make you sleepy.
    Upsides and benefits
    RozeremDoxepin
    • Rozerem (ramelteon) isn't a controlled medicine, and it's safe to use in people age 65 or older.
    • If you stop taking Rozerem (ramelteon) suddenly, your insomnia won't come back.
    • Rozerem (ramelteon) won't make you feel hungover or groggy the next day.
    • In clinical trials, Zonalon (Doxepin) was found to be the most effective cream for treating itchy skin.
    • You can use Zonalon (Doxepin) for up to 8 days at a time.
    Downsides and risks
    RozeremDoxepin
    • Rozerem (ramelteon) is only available as a brand name.
    • Rozerem (ramelteon) is only available in 1 strength.
    • If you take Rozerem (ramelteon) on a full stomach, it won't work as well.
    • Not recommended for children.
    • Rozerem (ramelteon) can't be used if you have sleep apnea.
    • You need a prescription for Zonalon (Doxepin).
    • It isn't available as a generic, so it could be kind of pricey.
    • Zonalon (Doxepin) can make you sleepy.
    • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
    Tips from our pharmacists for people taking the medication
    RozeremDoxepin
    • Take Rozerem (ramelteon) on an empty stomach 30 minutes before you sleep.
    • Don't take Rozerem (ramelteon) if you're not able to sleep for at least 8 hours.
    • Swallow the Rozerem (ramelteon) tablet whole; don't break or crush it.
    • While taking Rozerem (ramelteon), don't drink alcohol or take other medicines that can make you sleepy, like opioids for pain relief, or benzodiazepines for anxiety.
    • If you're not sleeping better after taking Rozerem (ramelteon) for 7 to 10 days, talk to your doctor.
    • Be sure the affected area is clean and dry before applying Zonalon (Doxepin).
    • Wash your hands before and after using it.
    • Apply a thin layer of Zonalon (Doxepin) onto the affected area and rub it in gently.
    • Don’t put a bandage, dressing, or make-up over Zonalon (Doxepin) once it's on your skin.
    • It shouldn't affect you too much, but avoid activities that need you to be fully alert (like driving) until you know how it works.
    Learn more
    More about RozeremSide effectsAlternativesFDA package insert
    Have you used Rozerem (ramelteon)?
    Worth itNot sureNot worth it
    More about DoxepinSide effectsFDA package insert
    Have you used Zonalon (doxepin)?
    Worth itNot sureNot worth it