Compare Rozerem vs. Oleptro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Rozerem
(ramelteon)

Oleptro
(Trazodone)

Helps you fall asleep. Rozerem (ramelteon) is a good sleep medicine that's not addictive, but it can be expensive.Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.
Reviews & ratings
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Have you used Rozerem (ramelteon)?
Worth itNot sureNot worth it
Reviews for Oleptro
73%
-73% worse vs. Rozerem
49%
-49% worse vs. Rozerem
24%
+24% better vs. Rozerem
Have you used Oleptro (Trazodone)?
Worth itNot sureNot worth it
Side effects
RozeremOleptro
  • Sleepiness 1%
  • Fatigue 1%
  • Nausea 1%
  • Worsening insomnia 1%
  • Dizziness 1%
More Rozerem side effects »
  • Incoordination 2%
  • Ejaculation disorders 2%
  • Decreased libido 2%
  • Hypotension 4%
  • Diarrhea 3%
  • Syncope 4%
  • Musculoskeletal Aches/Pains 2%
  • Tremors 1%
  • Weight Gain 3%
More Oleptro side effects »
How it works
RozeremOleptro
Rozerem (ramelteon) is a melatonin receptor agonist. Melatonin is a chemical the body uses to maintain a normal sleeping cycle; Rozerem (ramelteon) helps you fall asleep and stay asleep.Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
RozeremOleptro
Prescription onlyNo lower cost generic availablePrescription onlyLower-cost generic available
Available as
RozeremOleptro
  • Pill
  • Pill
  • Extended release
Used for
RozeremOleptro
Risk factors for serious side effects
RozeremOleptro
  • Alcohol
  • Taking narcotics, tranquilizers, or antihistamines
Detailed Rozerem (ramelteon) risks & warnings »
  • Age 24 years or younger
  • History of seizures
  • Alcoholism
  • Eating disorder
  • Higher dose
Detailed Oleptro (Trazodone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
RozeremOleptro
  • While taking Rozerem (ramelteon), don't drink alcohol or take other medicines that can make you sleepy, like opioids for pain relief, or benzodiazepines for anxiety.
No alcohol related info.
Pain
RozeremOleptro
  • If you’re taking Rozerem (ramelteon), you need to be very careful about drinking alcohol, or taking medicines such as narcotics for pain relief, tranquilizers for anxiety, or antihistamines. Taking Rozerem (ramelteon) with alcohol or these medicines can slow down your central nervous system to the point where you stop breathing. Talk to your doctor to see if you should change your other medicines while you take Rozerem (ramelteon).
No pain related info.
Sleep
RozeremOleptro
  • Don't take Rozerem (ramelteon) if you're not able to sleep for at least 8 hours.
  • If you're not sleeping better after taking Rozerem (ramelteon) for 7 to 10 days, talk to your doctor.
No sleep related info.
Upsides and benefits
RozeremOleptro
  • Rozerem (ramelteon) isn't a controlled medicine, and it's safe to use in people age 65 or older.
  • If you stop taking Rozerem (ramelteon) suddenly, your insomnia won't come back.
  • Rozerem (ramelteon) won't make you feel hungover or groggy the next day.
  • Commonly used in lower doses to help treat sleep problems (insomnia).
  • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
  • Fewer sexual side effects than many other antidepressants.
  • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
  • Comes as a generic medication and is cheaper than many other sleep aides.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides and risks
RozeremOleptro
  • Rozerem (ramelteon) is only available as a brand name.
  • Rozerem (ramelteon) is only available in 1 strength.
  • If you take Rozerem (ramelteon) on a full stomach, it won't work as well.
  • Not recommended for children.
  • Rozerem (ramelteon) can't be used if you have sleep apnea.
  • Not as effective as other medications for depression.
  • More sedating than other antidepressants.
  • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Tips from our pharmacists for people taking the medication
RozeremOleptro
  • Take Rozerem (ramelteon) on an empty stomach 30 minutes before you sleep.
  • Don't take Rozerem (ramelteon) if you're not able to sleep for at least 8 hours.
  • Swallow the Rozerem (ramelteon) tablet whole; don't break or crush it.
  • While taking Rozerem (ramelteon), don't drink alcohol or take other medicines that can make you sleepy, like opioids for pain relief, or benzodiazepines for anxiety.
  • If you're not sleeping better after taking Rozerem (ramelteon) for 7 to 10 days, talk to your doctor.
  • Makes you sleepy. Take at bedtime.
  • Can cause temporary dry mouth and upset stomach.
  • Seek medical attention for unwanted, persistent erection.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
Learn more
More about RozeremSide effectsAlternativesFDA package insert
Have you used Rozerem (ramelteon)?
Worth itNot sureNot worth it
More about OleptroSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Oleptro (Trazodone)?
Worth itNot sureNot worth it