Compare Rozerem vs. Remeron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Rozerem
(ramelteon)

Remeron
(mirtazapine)

Helps you fall asleep. Rozerem (ramelteon) is a good sleep medicine that's not addictive, but it can be expensive.Improves mood. Remeron (Mirtazapine) is okay for treating depression and good for sleep. More likely to cause weight gain than any other antidepressant.
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Prices and coupon for 30 (8mg) tablets of ramelteon
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Prices and coupon for 30 (15mg) tablets of mirtazapine
Reviews & ratings
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Have you used Rozerem (ramelteon)?
Worth itNot sureNot worth it
Reviews for Remeron (mirtazapine)
45%
+45% better vs. Rozerem (ramelteon)
39%
+39% better vs. Rozerem (ramelteon)
26%
-26% worse vs. Rozerem (ramelteon)
152 reviews
Have you used Remeron (mirtazapine)?
Worth itNot sureNot worth it
Side effects
RozeremRemeron
  • Dizziness 1%
  • Sleepiness 1%
  • Fatigue 1%
  • Nausea 1%
  • Worsening insomnia 1%
More Rozerem side effects »
  • Drowsiness 36%
  • Dry mouth 10%
  • Increased appetite 15%
  • Constipation 6%
  • Weight gain 10%
  • Muscle weakness 3%
  • Dizziness 4%
  • Flu syndrome 2%
  • Abnormal dreams 3%
  • Thinking abnormal 2%
More Remeron side effects »
How it works
RozeremRemeron
Rozerem (ramelteon) is a melatonin receptor agonist. Melatonin is a chemical the body uses to maintain a normal sleeping cycle; Rozerem (ramelteon) helps you fall asleep and stay asleep.Remeron (Mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.
Type of medication
RozeremRemeron
Prescription only
Prescription only
Available as
RozeremRemeron
  • Pill
  • Pill
  • Dissolving tablet
Used for
RozeremRemeron
Risk factors for serious side effects
RozeremRemeron
        • Alcohol
        • Taking narcotics, tranquilizers, or antihistamines
          Detailed Rozerem (ramelteon) risks & warnings »
          • Age 24 years or younger
          • Using other medications that affect serotonin
          • History of heart problems
          • History of liver problems
          • Higher dose
          • Alcohol
          • Taking other medicines that make you less alert
              Detailed Remeron (mirtazapine) risks & warnings »
              Pregnancy

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Alcohol
              RozeremRemeron
              • While taking Rozerem (ramelteon), don't drink alcohol or take other medicines that can make you sleepy, like opioids for pain relief, or benzodiazepines for anxiety.
              No alcohol related info.
              Pain
              RozeremRemeron
              • If you’re taking Rozerem (ramelteon), you need to be very careful about drinking alcohol, or taking medicines such as narcotics for pain relief, tranquilizers for anxiety, or antihistamines. Taking Rozerem (ramelteon) with alcohol or these medicines can slow down your central nervous system to the point where you stop breathing. Talk to your doctor to see if you should change your other medicines while you take Rozerem (ramelteon).
              No pain related info.
              Sleep
              RozeremRemeron
              • Don't take Rozerem (ramelteon) if you're not able to sleep for at least 8 hours.
              • If you're not sleeping better after taking Rozerem (ramelteon) for 7 to 10 days, talk to your doctor.
              No sleep related info.
              Weight
              RozeremRemeron
              No weight related info.
              • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
              • Can increase appetite and weight.
              • Remeron (Mirtazapine) can increase appetite and cause you to gain weight.
              Upsides and benefits
              RozeremRemeron
              • Rozerem (ramelteon) isn't a controlled medicine, and it's safe to use in people age 65 or older.
              • If you stop taking Rozerem (ramelteon) suddenly, your insomnia won't come back.
              • Rozerem (ramelteon) won't make you feel hungover or groggy the next day.
              • Effective at relieving some depression symptoms.
              • Starts to work more quickly than most antidepressants.
              • Might be a good option for people who have insomnia with their depression, because it can make you very sleepy.
              • Good option for people who are underweight or frail, because it can help you gain weight.
              • Six out of ten people who use an antidepressant for the first time find that it works for them.
              Downsides and risks
              RozeremRemeron
              • Rozerem (ramelteon) is only available as a brand name.
              • Rozerem (ramelteon) is only available in 1 strength.
              • If you take Rozerem (ramelteon) on a full stomach, it won't work as well.
              • Not recommended for children.
              • Rozerem (ramelteon) can't be used if you have sleep apnea.
              • Not as effective as other medications for depression.
              • More sedating than other antidepressants.
              • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
              • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
              • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
              Tips from our pharmacists for people taking the medication
              RozeremRemeron
              • Take Rozerem (ramelteon) on an empty stomach 30 minutes before you sleep.
              • Don't take Rozerem (ramelteon) if you're not able to sleep for at least 8 hours.
              • Swallow the Rozerem (ramelteon) tablet whole; don't break or crush it.
              • While taking Rozerem (ramelteon), don't drink alcohol or take other medicines that can make you sleepy, like opioids for pain relief, or benzodiazepines for anxiety.
              • If you're not sleeping better after taking Rozerem (ramelteon) for 7 to 10 days, talk to your doctor.
              • Makes you sleepy. Take at bedtime.
              • Can increase appetite and weight.
              • Takes 8 to 12 weeks to see full effects on mood.
              • Stop taking slowly to avoid withdrawal symptoms.
              • Tell your doctor if you notice sudden mood changes or unusual thoughts.
              Learn more
              More about RozeremSide effectsAlternativesFDA package insert
              Have you used Rozerem (ramelteon)?
              Worth itNot sureNot worth it
              More about RemeronSide effectsReviews & ratingsAlternativesFDA package insert
              Have you used Remeron (mirtazapine)?
              Worth itNot sureNot worth it