Compare Saphris vs. Ativan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Saphris
(Asenapine)

Ativan
(Lorazepam)

Coming soon.Helps you relax. Ativan (Lorazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety and sleep. Less likely to have drug interactions, but more likely to cause withdrawal symptoms compared to similar drugs.
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Reviews & ratings
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Have you used Saphris (Asenapine)?
Worth itNot sureNot worth it
Reviews for Ativan (Lorazepam)
71%
+21% better vs. Saphris (Asenapine)
51%
+13% better vs. Saphris (Asenapine)
15%
-2% worse vs. Saphris (Asenapine)
642 reviews
Have you used Ativan (Lorazepam)?
Worth itNot sureNot worth it
Side effects
SaphrisAtivan

We haven’t found good data for Saphris side effects.

FDA side effect reports for Saphris »
  • Relaxation or sleepiness 16%
  • Dizziness 7%
  • Weakness 4%
  • Unsteadiness 3%
More Ativan side effects »
How it works
SaphrisAtivan
Coming soon.Ativan (Lorazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and can cause sleepiness.
Type of medication
SaphrisAtivan
Prescription only
Available as
SaphrisAtivan
  • Pill
  • Pill
  • Liquid
Used for
SaphrisAtivan
  • Bipolar I Disorder
Risk factors for serious side effects
SaphrisAtivan
Coming soon.
  • Taking more than the prescribed dose
  • Taking longer than 4 weeks
  • History of drug abuse
  • Long-term use
    • Alcohol
    • Taking other medicines that make you less alert
      Detailed Ativan (Lorazepam) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Interactions
      SaphrisAtivan
      No interactions related info.
      • Less likely to have drug interactions compared to other benzodiazepines, so it might be a better option if you're taking multiple medications.
      Alcohol
      SaphrisAtivan
      No alcohol related info.
      • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
      • Not safe to use with alcohol.
      Sleep
      SaphrisAtivan
      No sleep related info.
      • Can cause memory problems, drowsiness, dizziness, and confusion.
      • Can cause temporary dizziness and drowsiness.
      Upsides and benefits
      SaphrisAtivan
      Coming soon
      • Effective at relieving short-term anxiety and sleeplessness.
      • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
      • Less likely to have drug interactions compared to other benzodiazepines, so it might be a better option if you're taking multiple medications.
      Downsides and risks
      SaphrisAtivan
      Coming soon
      • Can cause memory problems, drowsiness, dizziness, and confusion.
      • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
      • Compared to other benzodiazepines, more likely to cause withdrawal if you take it for a long time and then stop suddenly.
      • Most people find that it gets less effective over time.
      Tips from our pharmacists for people taking the medication
      SaphrisAtivan
      Coming soon
      • Good for short-term relief of anxiety symptoms.
      • Starts working in 45 minutes when swallowed.
      • Starts working in 10 to 20 minutes when dissolved under your tongue.
      • Can cause temporary dizziness and drowsiness.
      • Addictive. Long-term use can cause dependence or abuse.
      • Not safe to use with alcohol.
      Learn more
      More about SaphrisSide effectsReviews & ratingsFDA package insert
      Have you used Saphris (Asenapine)?
      Worth itNot sureNot worth it
      More about AtivanSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Ativan (Lorazepam)?
      Worth itNot sureNot worth it