Compare Saphris vs. Ativan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Saphris
(Asenapine)

Ativan
(Lorazepam)

Coming soon.Helps you relax. Ativan (Lorazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety and sleep. Less likely to have drug interactions, but more likely to cause withdrawal symptoms compared to similar drugs.
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Reviews & ratings
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Reviews for Ativan (Lorazepam)
70%
+3% vs. Saphris (Asenapine)
50%
Same vs. Saphris (Asenapine)
15%
+2% vs. Saphris (Asenapine)
Side effects
SaphrisAtivan

We haven’t found good data for Saphris side effects.

FDA side effect reports for Saphris »

The Ativan FDA package insert doesn’t have numbers about how common side effects are.

More about Ativan side effects »
How it works
SaphrisAtivan
Coming soon.Ativan (Lorazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and can cause sleepiness.
Type of medication
SaphrisAtivan
Coming soon.
Anti-anxiety
Benzodiazepine
Prescription only
Available as
SaphrisAtivan
  • Pill
  • Pill
  • Liquid
Used for (click to learn more)
SaphrisAtivan
  • Bipolar I disorder
Risk factors for serious side effects
SaphrisAtivan
Coming soon.
  • Taking more than the prescribed dose
  • Taking longer than 4 weeks
  • History of drug abuse
  • Long-term use
    • Alcohol
    • Taking other medicines that make you less alert
      Detailed Ativan (Lorazepam) risks & warnings »
      Pregnancy category
      SaphrisAtivan
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      DFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.
      • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
      • Not safe to use with alcohol.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.
      • Can cause memory problems, drowsiness, dizziness, and confusion.
      • Can cause temporary dizziness and drowsiness.
      • Stopping Ativan (Lorazepam) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and muscle pain or burning. Withdrawal symptoms can last 6 weeks or longer. Work with your doctor to gradually reduce your dose.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      SaphrisAtivan
      Coming soon.
      • Effective at relieving short-term anxiety and sleeplessness.
      • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
      • Less likely to have drug interactions compared to other benzodiazepines, so it might be a better option if you're taking multiple medications.
      Downsides and risks
      SaphrisAtivan
      Coming soon.
      • Can cause memory problems, drowsiness, dizziness, and confusion.
      • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
      • Compared to other benzodiazepines, more likely to cause withdrawal if you take it for a long time and then stop suddenly.
      • Most people find that it gets less effective over time.
      Tips from our pharmacists for people taking the medication
      SaphrisAtivan
      Coming soon.
      • Good for short-term relief of anxiety symptoms.
      • Starts working in 45 minutes when swallowed.
      • Starts working in 10 to 20 minutes when dissolved under your tongue.
      • Can cause temporary dizziness and drowsiness.
      • Addictive. Long-term use can cause dependence or abuse.
      • Not safe to use with alcohol.
      Learn more
      More about SaphrisSide effectsReviews & ratingsFDA package insert
      More about AtivanSide effectsReviews & ratingsAlternativesFDA package insert