Compare Saphris vs. Seroquel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Saphris
(Asenapine)

Seroquel
(Quetiapine)

Coming soon.Helps control your thoughts and mood. Seroquel (Quetiapine) is good for treating psychosis and mania. Fewer side effects than most antipsychotics, but might be less effective for people over age 40 with schizophrenia.
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  • Coupons for Saphris (Asenapine)
  • Cost for (30) 10mg orally disintegrating tab of Saphris (Asenapine)
Reviews & ratings
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Have you used Saphris (Asenapine)?
Worth itNot sureNot worth it
Reviews for Seroquel (Quetiapine)
52%
15% vs. Saphris (Asenapine)
46%
4% vs. Saphris (Asenapine)
28%
11% vs. Saphris (Asenapine)
204 reviews
Have you used Seroquel (Quetiapine)?
Worth itNot sureNot worth it
Side effects
SaphrisSeroquel

We haven’t found good data for Saphris side effects.

FDA side effect reports for Saphris »
  • Drowsiness 42%
  • Dry mouth 31%
  • Dizziness 17%
  • Fatigue 10%
  • Increased appetite 9%
  • Headache 7%
  • Nausea 6%
  • Constipation 6%
  • Muscle weakness 6%
  • Positional low blood pressure 5%
More Seroquel side effects »
How it works
SaphrisSeroquel
Coming soon.Seroquel (Quetiapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.
Type of medication
SaphrisSeroquel
Coming soon.
Antipsychotic
Atypical
Prescription only
Available as
SaphrisSeroquel
  • Pill
  • Pill
  • Extended release
Used for (click to learn more)
SaphrisSeroquel
  • Bipolar I disorder
Risk factors for serious side effects
SaphrisSeroquel
Coming soon.
  • Elderly patients with dementia
      • History of heart problems
      • Drug interactions
        • People with diabetes
        • People with high cholesterol
        • People with diabetes
        • Alcohol
        • Taking other medicines that make you less alert
          Detailed Seroquel (Quetiapine) risks & warnings »
          Pregnancy

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Food
          SaphrisSeroquel
          No food related info.
          • Seroquel (Quetiapine) can increase your blood sugar and cholesterol. Seroquel (Quetiapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
          • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
          Sleep
          SaphrisSeroquel
          No sleep related info.
          • Can cause dizziness, drowsiness, and low blood pressure.
          Weight
          SaphrisSeroquel
          No weight related info.
          • Sometimes causes weight gain, sleepiness, and low blood pressure.
          • May cause weight gain and worsen cholesterol or blood sugar.
          • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
          Upsides and benefits
          SaphrisSeroquel
          Coming soon
          • Effective at relieving psychotic symptoms and manic episodes.
          • Antipsychotic medicines are all about equally effective.
          • Fewer side effects than most antipsychotic medicines.
          • Less likely to cause heart problems compared to some antipsychotics.
          • Compared to other antipsychotics, the least likely to cause Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
          Downsides and risks
          SaphrisSeroquel
          Coming soon
          • In studies, less effective for people over age 40 for schizophrenia.
          • Sometimes causes weight gain, sleepiness, and low blood pressure.
          • You might need routine blood tests to check how the medicine is affecting your body.
          • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
          Tips from our pharmacists for people taking the medication
          SaphrisSeroquel
          Coming soon
          • Takes 4 to 6 weeks to see full effects on thoughts and mood.
          • Can cause dizziness, drowsiness, and low blood pressure.
          • For the first week, avoid activities that require you to be alert.
          • May cause weight gain and worsen cholesterol or blood sugar.
          • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
          • Elderly people with dementia shouldn't take it.
          Learn more
          More about SaphrisSide effectsReviews & ratingsFDA package insert
          Have you used Saphris (Asenapine)?
          Worth itNot sureNot worth it
          More about SeroquelSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Seroquel (Quetiapine)?
          Worth itNot sureNot worth it