Compare scopolamine vs. Compro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Transderm-Scop
(scopolamine)

Compro
(prochlorperazine)

Prevents nausea and vomiting. Transderm-Scop (scopolamine) is a low-hassle patch that works well to prevent nausea and vomiting, but it takes several hours to work.Helps you feel less queasy. Compro (Prochlorperazine) can be used to treat severe nausea and vomiting and can be taken orally or rectally, but get ready for a nap.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.35scopolamine
Reviews for scopolamine
73%
of people (All ages) say scopolamine is worth it
58%
say it works well
19%
say it's a big hassle
Have you used Transderm-Scop (scopolamine)?
Worth itNot sureNot worth it
Reviews for Compro
45%
+28% better vs. scopolamine
35%
+23% better vs. scopolamine
35%
+16% better vs. scopolamine
Have you used Compro (prochlorperazine)?
Worth itNot sureNot worth it
Side effects
scopolamineCompro
  • Dry mouth 12%
  • Dizziness 5%
  • Drowsiness 4%
  • Agitation 2%
  • Visual changes 2%
  • Confusion 1%
  • Dilated pupils 4%
  • Sore throat 1%
More scopolamine side effects »

The Compro FDA package insert doesn’t have numbers about how common side effects are.

More about Compro side effects »
How it works
scopolamineCompro
Transderm-Scop (scopolamine) is an anti-nausea medicine. It works by blocking signals in the part of your brain that causes vomiting.Compro (Prochlorperazine) is an antiemetic (anti-nausea medicine). It works by blocking signals in the part of your brain that causes vomiting.
Type of medication
scopolamineCompro
Prescription onlyPrescription only
Available as
scopolamineCompro
  • Patch
  • Pill
  • Suppository
Used for
scopolamineCompro
Risk factors for serious side effects
scopolamineCompro
  • Open angle glaucoma
  • Blockages in the stomach, bowels or bladder
  • MRI examination
  • History of seizures
  • History of psychosis
Detailed Transderm-Scop (scopolamine) risks & warnings »
  • Over age 65
  • Dementia
  • Taking antipsychotics
  • History of seizures
  • Age over 65
Detailed Compro (prochlorperazine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
scopolamineCompro
No alcohol related info.
  • Don't drink alcohol to avoid intense side effects.
Pain
scopolamineCompro
No pain related info.
  • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Compro.
Sleep
scopolamineCompro
  • You might feel sleepy, drowsy, or have blurry vision while taking Transderm-Scop (scopolamine). Taking alcohol or other medicines that make you drowsy can make this effect worse.
  • You'll likely feel very sleepy, sluggish, or less alert after taking Compro. Avoid driving or other tasks that require your focused attention; be safe.
  • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
Upsides and benefits
scopolamineCompro
  • Transderm-Scop (scopolamine) is well tolerated.
  • Prevents nausea for 3 days.
  • Because Transderm-Scop (scopolamine) is a skin patch, it's a good alternative to stopping nausea and vomiting if you're not able to swallow pills.
  • Available in generic, so it's cheap.
  • Can be taken by mouth, as a shot, or rectally.
  • Can take anywhere from 10 minutes (by shot) to 60 minutes (rectally) to start working.
Downsides and risks
scopolamineCompro
  • Can only be used for prevention of nausea and vomiting. It can't stop nausea or vomiting that's already happening.
  • The side effects can be worse if you are 65 and older.
  • You might feel sleepy, drowsy, or have blurry vision while taking Transderm-Scop (scopolamine). Taking alcohol or other medicines that make you drowsy can make this effect worse.
  • You're more likely to have heat stroke or feel dehydrated.
  • It takes a few hours for Transderm-Scop (scopolamine) to kick in, so you have to remember to take it beforehand.
  • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
  • Can't be used by people over 65 because they can be more affected by the side effects.
  • It can make you more likely to get heatstroke.
Tips from our pharmacists for people taking the medication
scopolamineCompro
  • Starts working in 6 to 8 hours.
  • Apply Transderm-Scop (scopolamine) to a clean, dry, hairless area of the skin behind the ear. Press down for 30 seconds to make sure the patch stays firmly.
  • After handling the patch, make sure to wash your hands with soap and water to avoid accidental contact with your eyes.
  • If the patch comes off, throw it away and use a new patch.
  • You can prevent skin irritation by alternating ears and washing the area of your ear that you had placed the patch on.
  • If you're using this before surgery, place it the day before, then leave it on until the day after your surgery.
  • Take the patch off before you have an MRI because it can cause the skin to burn.
  • Compro comes in different forms. Be clear on which one you were prescribed - swallow tablets orally, unwrap and insert suppositories rectally.
  • You'll likely feel very sleepy, sluggish, or less alert after taking Compro. Avoid driving or other tasks that require your focused attention; be safe.
  • Don't drink alcohol to avoid intense side effects.
  • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Compro.
  • Avoid using if you experience seizures (epilepsy).
  • Don't use if you're 65 or older because you're at higher risk for serious side effects.
Learn more
More about scopolamineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Transderm-Scop (scopolamine)?
Worth itNot sureNot worth it
More about ComproSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Compro (prochlorperazine)?
Worth itNot sureNot worth it