Compare Seroquel vs. Ativan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Seroquel
(quetiapine)

Ativan
(lorazepam)

Helps control your thoughts and mood. Seroquel (Quetiapine) is good for treating psychosis and mania. Fewer side effects than most antipsychotics, but might be less effective for people over age 40 with schizophrenia.Helps you relax. Ativan (Lorazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety and sleep. Less likely to have drug interactions, but more likely to cause withdrawal symptoms compared to similar drugs.
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Prices and coupon for 30 (25mg) tablets of quetiapine
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Prices and coupon for 60 (0.5mg) tablets of lorazepam
Reviews & ratings
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5Seroquel
Reviews for Seroquel (quetiapine)
56%
of people (All ages) say Seroquel (quetiapine) is worth it
50%
say it works well
27%
say it's a big hassle
250 reviews
Have you used Seroquel (quetiapine)?
Worth itNot sureNot worth it
Reviews for Ativan (lorazepam)
71%
+15% better vs. Seroquel (quetiapine)
51%
+1% better vs. Seroquel (quetiapine)
15%
+12% better vs. Seroquel (quetiapine)
642 reviews
Have you used Ativan (lorazepam)?
Worth itNot sureNot worth it
Side effects
SeroquelAtivan
  • Drowsiness 42%
  • Dizziness 15%
  • Nausea 6%
  • Fatigue 5%
  • Increased appetite 8%
  • Abnormally fast heart beat 8%
  • Vomiting 4%
  • Dry mouth 7%
  • Nasal congestion 4%
  • Weight increased 6%
More Seroquel side effects »
  • Relaxation or sleepiness 16%
  • Dizziness 7%
  • Weakness 4%
  • Unsteadiness 3%
More Ativan side effects »
How it works
SeroquelAtivan
Seroquel (Quetiapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Ativan (Lorazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and can cause sleepiness.
Type of medication
SeroquelAtivan
Prescription only
Prescription only
Available as
SeroquelAtivan
  • Pill
  • Extended release
  • Pill
  • Liquid
Used for
SeroquelAtivan
Risk factors for serious side effects
SeroquelAtivan
  • Elderly patients with dementia
      • History of heart problems
      • Drug interactions
        • People with diabetes
        • People with high cholesterol
        • People with diabetes
        • Alcohol
        • Taking other medicines that make you less alert
          Detailed Seroquel (quetiapine) risks & warnings »
          • Taking more than the prescribed dose
          • Taking longer than 4 weeks
          • History of drug abuse
          • Long-term use
            • Alcohol
            • Taking other medicines that make you less alert
              Detailed Ativan (lorazepam) risks & warnings »
              Pregnancy

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Interactions
              SeroquelAtivan
              No interactions related info.
              • Less likely to have drug interactions compared to other benzodiazepines, so it might be a better option if you're taking multiple medications.
              Alcohol
              SeroquelAtivan
              No alcohol related info.
              • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
              • Not safe to use with alcohol.
              Food
              SeroquelAtivan
              • Seroquel (Quetiapine) can increase your blood sugar and cholesterol. Seroquel (Quetiapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
              • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
              No food related info.
              Sleep
              SeroquelAtivan
              • Can cause dizziness, drowsiness, and low blood pressure.
              • Can cause memory problems, drowsiness, dizziness, and confusion.
              • Can cause temporary dizziness and drowsiness.
              Weight
              SeroquelAtivan
              • Sometimes causes weight gain, sleepiness, and low blood pressure.
              • May cause weight gain and worsen cholesterol or blood sugar.
              • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
              No weight related info.
              Upsides and benefits
              SeroquelAtivan
              • Effective at relieving psychotic symptoms and manic episodes.
              • Antipsychotic medicines are all about equally effective.
              • Fewer side effects than most antipsychotic medicines.
              • Less likely to cause heart problems compared to some antipsychotics.
              • Compared to other antipsychotics, the least likely to cause Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
              • Effective at relieving short-term anxiety and sleeplessness.
              • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
              • Less likely to have drug interactions compared to other benzodiazepines, so it might be a better option if you're taking multiple medications.
              Downsides and risks
              SeroquelAtivan
              • In studies, less effective for people over age 40 for schizophrenia.
              • Sometimes causes weight gain, sleepiness, and low blood pressure.
              • You might need routine blood tests to check how the medicine is affecting your body.
              • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
              • Can cause memory problems, drowsiness, dizziness, and confusion.
              • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
              • Compared to other benzodiazepines, more likely to cause withdrawal if you take it for a long time and then stop suddenly.
              • Most people find that it gets less effective over time.
              Tips from our pharmacists for people taking the medication
              SeroquelAtivan
              • Takes 4 to 6 weeks to see full effects on thoughts and mood.
              • Can cause dizziness, drowsiness, and low blood pressure.
              • For the first week, avoid activities that require you to be alert.
              • May cause weight gain and worsen cholesterol or blood sugar.
              • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
              • Elderly people with dementia shouldn't take it.
              • Good for short-term relief of anxiety symptoms.
              • Starts working in 45 minutes when swallowed.
              • Starts working in 10 to 20 minutes when dissolved under your tongue.
              • Can cause temporary dizziness and drowsiness.
              • Addictive. Long-term use can cause dependence or abuse.
              • Not safe to use with alcohol.
              Learn more
              More about SeroquelSide effectsReviews & ratingsAlternativesFDA package insert
              Have you used Seroquel (quetiapine)?
              Worth itNot sureNot worth it
              More about AtivanSide effectsReviews & ratingsAlternativesFDA package insert
              Have you used Ativan (lorazepam)?
              Worth itNot sureNot worth it