Compare Seroquel vs. chlorpromazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Seroquel
(quetiapine)

Thorazine
(chlorpromazine)

Helps control your thoughts and mood. Seroquel (Quetiapine) is good for treating psychosis and mania. Fewer side effects than most antipsychotics, but might be less effective for people over age 40 with schizophrenia.Stabilizes your mood. Thorazine (chlorpromazine) has more side effects than other medicines like it. It is most useful during psychotic episodes because it slows you down quickly.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5Seroquel
Reviews for Seroquel
56%
of people (All ages) say Seroquel is worth it
50%
say it works well
27%
say it's a big hassle
250 reviews
Have you used Seroquel (quetiapine)?
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Have you used Thorazine (chlorpromazine)?
Worth itNot sureNot worth it
Side effects
Seroquelchlorpromazine
  • Somnolence 42%
  • Dizziness 15%
  • Nausea 6%
  • Fatigue 5%
  • Increased Appetite 8%
  • Tachycardia 8%
  • Vomiting 4%
  • Dry Mouth 7%
  • Nasal Congestion 4%
  • Weight Increased 6%
More Seroquel side effects »

The chlorpromazine FDA package insert doesn’t have numbers about how common side effects are.

More about chlorpromazine side effects »
How it works
Seroquelchlorpromazine
Seroquel (Quetiapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Thorazine (chlorpromazine) is a derivative of phenothiazine, which regulates dopamine levels in your brain to improve your mood.
Type of medication
Seroquelchlorpromazine
Prescription onlyPrescription only
Available as
Seroquelchlorpromazine
  • Pill
  • Extended release
  • Pill
  • Injection
Used for
Seroquelchlorpromazine
Risk factors for serious side effects
Seroquelchlorpromazine
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Seroquel (quetiapine) risks & warnings »
  • People over 65 with dementia and psychosis
  • Taking antipsychotic medications
  • Asthma
  • COPD
  • Acute respiratory infections
Detailed Thorazine (chlorpromazine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
Seroquelchlorpromazine
No alcohol related info.
  • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
Food
Seroquelchlorpromazine
  • Seroquel (Quetiapine) can increase your blood sugar and cholesterol. Seroquel (Quetiapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
No food related info.
Sleep
Seroquelchlorpromazine
  • Can cause dizziness, drowsiness, and low blood pressure.
  • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
Weight
Seroquelchlorpromazine
  • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Sometimes causes weight gain, sleepiness, and low blood pressure.
No weight related info.
Upsides and benefits
Seroquelchlorpromazine
  • Effective at relieving psychotic symptoms and manic episodes.
  • Antipsychotic medicines are all about equally effective.
  • Fewer side effects than most antipsychotic medicines.
  • Less likely to cause heart problems compared to some antipsychotics.
  • Compared to other antipsychotics, the least likely to cause Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • Acts fast to slow you down during a psychotic episode.
  • Can also be used for nausea or migraines.
  • Safe for use in children as young as 6 months.
  • Comes in a sugar-coated pill for easy administration.
Downsides and risks
Seroquelchlorpromazine
  • In studies, less effective for people over age 40 for schizophrenia.
  • Sometimes causes weight gain, sleepiness, and low blood pressure.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
  • Has more side effects than other medicines like it.
  • Can affect how your other medicines work.
  • Makes you more sensitive to the sun.
  • Can make you dizzy or lightheaded, especially when injected.
  • Cannot be stopped right away.
Tips from our pharmacists for people taking the medication
Seroquelchlorpromazine
  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
  • Can cause dizziness, drowsiness, and low blood pressure.
  • For the first week, avoid activities that require you to be alert.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take it.
  • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
  • Can cause involuntary muscle movements just like other medicines for your mood.
  • Can dry you out and make you more sensitive to the sun.
  • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
  • Cannot be stopped suddenly.
Learn more
More about SeroquelSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Seroquel (quetiapine)?
Worth itNot sureNot worth it
More about chlorpromazineSide effectsAlternativesFDA package insert
Have you used Thorazine (chlorpromazine)?
Worth itNot sureNot worth it