Compare Seroquel vs. fluphenazine decanoate

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Seroquel
(quetiapine)

Prolixin Decanoate
(fluphenazine decanoate)

Helps control your thoughts and mood. Seroquel (Quetiapine) is good for treating psychosis and mania. Fewer side effects than most antipsychotics, but might be less effective for people over age 40 with schizophrenia.Treats schizophrenia or psychosis. Prolixin Decanoate (fluphenazine decanoate) is long-acting medicine for stabilizing your mood that must be given by a trained healthcare professional.
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Reviews & ratings
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5Seroquel
Reviews for Seroquel
56%
of people (All ages) say Seroquel is worth it
50%
say it works well
27%
say it's a big hassle
250 reviews
Have you used Seroquel (quetiapine)?
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Have you used Prolixin Decanoate (fluphenazine decanoate)?
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Side effects
Seroquelfluphenazine decanoate
  • Drowsiness 42%
  • Dizziness 15%
  • Nausea 6%
  • Fatigue 5%
  • Increased appetite 8%
  • Abnormally fast heart beat 8%
  • Vomiting 4%
  • Dry mouth 7%
  • Nasal congestion 4%
  • Weight increased 6%
More Seroquel side effects »

The fluphenazine decanoate FDA package insert doesn’t have numbers about how common side effects are.

More about fluphenazine decanoate side effects »
How it works
Seroquelfluphenazine decanoate
Seroquel (Quetiapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Prolixin Decanoate (fluphenazine decanoate) is a derivative of phenothiazine. It regulates dopamine levels in your brain to control psychotic episodes or schizophrenia.
Type of medication
Seroquelfluphenazine decanoate
Prescription onlyPrescription only
Available as
Seroquelfluphenazine decanoate
  • Pill
  • Extended release
  • Injection
Used for
Seroquelfluphenazine decanoate
Risk factors for serious side effects
Seroquelfluphenazine decanoate
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Seroquel (quetiapine) risks & warnings »
  • People over 65 with dementia and psychosis
  • Taking antipsychotic medications
Detailed Prolixin Decanoate (fluphenazine decanoate) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
Seroquelfluphenazine decanoate
No alcohol related info.
  • Don't combine with alcohol or narcotics since it can stop your breathing.
Food
Seroquelfluphenazine decanoate
  • Seroquel (Quetiapine) can increase your blood sugar and cholesterol. Seroquel (Quetiapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
No food related info.
Sleep
Seroquelfluphenazine decanoate
  • Can cause dizziness, drowsiness, and low blood pressure.
  • Can make you very sleepy or dizzy. Don't drive or do anything that requires concentration until you know how it affects you.
Weight
Seroquelfluphenazine decanoate
  • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Sometimes causes weight gain, sleepiness, and low blood pressure.
No weight related info.
Upsides and benefits
Seroquelfluphenazine decanoate
  • Effective at relieving psychotic symptoms and manic episodes.
  • Antipsychotic medicines are all about equally effective.
  • Fewer side effects than most antipsychotic medicines.
  • Less likely to cause heart problems compared to some antipsychotics.
  • Compared to other antipsychotics, the least likely to cause Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • Can be given less frequently than the oral, short-acting version.
  • Available in generic.
Downsides and risks
Seroquelfluphenazine decanoate
  • In studies, less effective for people over age 40 for schizophrenia.
  • Sometimes causes weight gain, sleepiness, and low blood pressure.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
  • Can make you sensitive to the sun.
  • Can affect how your body regulates your temperature.
  • Can only be used if you're already stable on the short-acting version of this medicine.
Tips from our pharmacists for people taking the medication
Seroquelfluphenazine decanoate
  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
  • Can cause dizziness, drowsiness, and low blood pressure.
  • For the first week, avoid activities that require you to be alert.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take it.
  • Can make you more sensitive to the sun, so wear sunscreen or protective clothing while outside.
  • Can affect how your body regulates your temperature, so drink plenty of liquids especially when you're exercising.
  • Can make it difficult for you to start and stop your movements. Talk to your doctor right away if this happens.
  • Don't combine with alcohol or narcotics since it can stop your breathing.
  • Can make you very sleepy or dizzy. Don't drive or do anything that requires concentration until you know how it affects you.
Learn more
More about SeroquelSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Seroquel (quetiapine)?
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More about fluphenazine decanoateSide effectsAlternativesFDA package insert
Have you used Prolixin Decanoate (fluphenazine decanoate)?
Worth itNot sureNot worth it