Compare Seroquel vs. Geodon

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Seroquel
(Quetiapine)

Geodon
(Ziprasidone)

Helps control your thoughts and mood. Seroquel (Quetiapine) is good for treating psychosis and mania. Fewer side effects than most antipsychotics, but might be less effective for people over age 40 with schizophrenia.Helps control your thoughts and mood. Geodon (Ziprasidone) treats bipolar disorder and schizophrenia, and causes fewer side effects than similar medicines. It’s not a good choice if you have heart problems.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.818627450980392Seroquel
Reviews for Seroquel (Quetiapine)
52%
of people say Seroquel (Quetiapine) is worth it
46%
say it works well
28%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
SeroquelGeodon
  • Drowsiness 42%
  • Dry mouth 31%
  • Dizziness 17%
  • Fatigue 10%
  • Increased appetite 9%
  • Headache 7%
  • Nausea 6%
  • Constipation 6%
  • Muscle weakness 6%
  • Positional low blood pressure 5%
More Seroquel side effects »
  • Drowsiness 19%
  • Extrapyramidal symptoms 19%
  • Dizziness 9%
  • Restlessness 5%
  • Respiratory tract infection 5%
  • Muscle weakness 4%
  • Adverse reaction 3%
  • Vomiting 3%
  • Abnormal vision 3%
  • Accidental injury 2%
More Geodon side effects »
How it works
SeroquelGeodon
Seroquel (Quetiapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Geodon (Ziprasidone) is a second generation antipsychotic. It treats schizophrenia and bipolar disorder by adjusting the levels of dopamine and serotonin in your brain, which affects thoughts and mood.
Type of medication
SeroquelGeodon
Antipsychotic
Atypical
Prescription only
Antipsychotic
2nd generation
Prescription only
Available as
SeroquelGeodon
  • Pill
  • Extended release
  • Pill
  • Injection
Used for (click to learn more)
SeroquelGeodon
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Seroquel (Quetiapine)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Geodon (Ziprasidone)
Risk factors for serious side effects
SeroquelGeodon
  • Elderly patients with dementia
      • History of heart problems
      • Drug interactions
        • People with diabetes
        • People with high cholesterol
        • People with diabetes
        • Alcohol
        • Taking other medicines that make you less alert
          Detailed Seroquel (Quetiapine) risks & warnings »
          • Elderly patients with dementia
            • History of heart problems
            • Drug interactions
            • Low potassium
            • Low magnesium
              • Duration of treatment
                • Women of childbearing age
                Detailed Geodon (Ziprasidone) risks & warnings »
                Pregnancy category
                SeroquelGeodon
                CFDA pregnancy category (Weigh risks vs. benefits)

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                See the FDA package insert
                CFDA pregnancy category (Weigh risks vs. benefits)

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                See the FDA package insert
                Alcohol
                No specific alcohol-related info.No specific alcohol-related info.
                Food
                • Seroquel (Quetiapine) can increase your blood sugar and cholesterol. Seroquel (Quetiapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                • Take Geodon (Ziprasidone) twice a day, preferably with food.
                Kidneys and liver
                No specific kidneys and liver-related info.No specific kidneys and liver-related info.
                Sex
                No specific sex-related info.No specific sex-related info.
                Sleep
                • Can cause dizziness, drowsiness, and low blood pressure.
                • Can cause drowsiness when you first start taking it, so avoid activities that require you to be alert until you know how it affects you.
                Weight
                • Sometimes causes weight gain, sleepiness, and low blood pressure.
                • May cause weight gain and worsen cholesterol or blood sugar.
                • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                • It causes slightly less weight gain than similar medicines.
                • Compared to other antipsychotics, it has a lower risk of weight gain, hyperglycemia, and hyperlipidemia.
                Upsides and benefits
                SeroquelGeodon
                • Effective at relieving psychotic symptoms and manic episodes.
                • Antipsychotic medicines are all about equally effective.
                • Fewer side effects than most antipsychotic medicines.
                • Less likely to cause heart problems compared to some antipsychotics.
                • Compared to other antipsychotics, the least likely to cause Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
                • Geodon (Ziprasidone) can be used with lithium or valproate to better treat bipolar disorder.
                • Geodon (Ziprasidone) can treat agitation in people with schizophrenia by reducing symptoms of anxiety, nervousness, and distress.
                • Compared to other antipsychotics, it has a lower risk of weight gain, hyperglycemia, and hyperlipidemia.
                • The Geodon (Ziprasidone) capsule is available as a generic.
                • The injectable form can treat sudden agitation in schizophrenia when it's not possible to use the capsules.
                • It's available as a pill that you take by mouth daily for continuous treatment and as an injection used for short-term treatment of agitation.
                Downsides and risks
                SeroquelGeodon
                • In studies, less effective for people over age 40 for schizophrenia.
                • Sometimes causes weight gain, sleepiness, and low blood pressure.
                • You might need routine blood tests to check how the medicine is affecting your body.
                • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
                • Elderly people with dementia shouldn’t take Geodon (Ziprasidone).
                • You shouldn’t take Geodon (Ziprasidone) if you have a history of heart problems (slow heart rate, recent heart attack, heart failure, or heart rhythm problems). It’s also not safe to take if you have low potassium or magnesium, or are taking medicines that increase the risk of this happening (diuretics).
                • You'll need to get blood tests before you start taking Geodon (Ziprasidone).
                • It causes slightly less weight gain than similar medicines.
                • Can't take Geodon (Ziprasidone) capsules and injections at the same time. Capsules should be used instead of the injection as soon as possible.
                Tips from our pharmacists for people taking the medication
                SeroquelGeodon
                • Takes 4 to 6 weeks to see full effects on thoughts and mood.
                • Can cause dizziness, drowsiness, and low blood pressure.
                • For the first week, avoid activities that require you to be alert.
                • May cause weight gain and worsen cholesterol or blood sugar.
                • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
                • Elderly people with dementia shouldn't take it.
                • It usually takes 4 to 6 weeks to see the full effects, so hang in there and wait until it works to figure out the right dose for you.
                • Take Geodon (Ziprasidone) twice a day, preferably with food.
                • Can cause drowsiness when you first start taking it, so avoid activities that require you to be alert until you know how it affects you.
                • Geodon (Ziprasidone) can cause heart problems, so call your doctor right away if you faint or feel a change in your heartbeat.
                • Let your doctor know if you're taking a diuretic (water pill) or have a condition like chronic diarrhea that'll lower the amount of potassium or magnesium in your blood.
                Learn more
                More about SeroquelSide effectsReviews & ratingsAlternativesFDA package insert
                More about GeodonSide effectsReviews & ratingsAlternativesFDA package insert