Compare Seroquel vs. Haldol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Seroquel
(Quetiapine)

Haldol
(Haloperidol)

Helps control your thoughts and mood. Seroquel (Quetiapine) is good for treating psychosis and mania. Fewer side effects than most antipsychotics, but might be less effective for people over age 40 with schizophrenia.Helps control your thoughts and calms agitation. Haldol (Haloperidol) is okay for treating psychosis and agitation. It's less likely to cause weight gain than other antipsychotics, but it's more likely to cause other bad side effects.
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Reviews & ratings
Filter group. All currently selected
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4.818627450980392Seroquel
Reviews for Seroquel (Quetiapine)
52%
of people (All ages) say Seroquel (Quetiapine) is worth it
46%
say it works well
28%
say it's a big hassle
204 reviews
Have you used Seroquel (Quetiapine)?
Worth itNot sureNot worth it
Reviews for Haldol (Haloperidol)
37%
15% vs. Seroquel (Quetiapine)
41%
5% vs. Seroquel (Quetiapine)
35%
7% vs. Seroquel (Quetiapine)
Have you used Haldol (Haloperidol)?
Worth itNot sureNot worth it
Side effects
SeroquelHaldol
  • Drowsiness 42%
  • Dry mouth 31%
  • Dizziness 17%
  • Fatigue 10%
  • Increased appetite 9%
  • Headache 7%
  • Nausea 6%
  • Constipation 6%
  • Muscle weakness 6%
  • Positional low blood pressure 5%
More Seroquel side effects »

The Haldol FDA package insert doesn’t have numbers about how common side effects are.

More about Haldol side effects »
How it works
SeroquelHaldol
Seroquel (Quetiapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Haldol (Haloperidol) is a traditional antipsychotic. Researchers don't know exactly how it works, but it seems to change dopamine activity in your brain, which affects thoughts and mood.
Type of medication
SeroquelHaldol
Antipsychotic
Atypical
Prescription only
Antipsychotic
Typical
Prescription only
Available as
SeroquelHaldol
  • Pill
  • Extended release
  • Pill
  • Liquid
  • Injection
Used for (click to learn more)
SeroquelHaldol
Risk factors for serious side effects
SeroquelHaldol
  • Elderly patients with dementia
      • History of heart problems
      • Drug interactions
        • People with diabetes
        • People with high cholesterol
        • People with diabetes
        • Alcohol
        • Taking other medicines that make you less alert
          Detailed Seroquel (Quetiapine) risks & warnings »
          • Elderly patients with dementia
              • History of heart problems
              • Drug interactions
                • People with diabetes
                • People with high cholesterol
                • People with diabetes
                • Alcohol
                • Taking other medicines that make you less alert
                  Detailed Haldol (Haloperidol) risks & warnings »
                  Pregnancy

                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  Food
                  SeroquelHaldol
                  • Seroquel (Quetiapine) can increase your blood sugar and cholesterol. Seroquel (Quetiapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • Haldol (Haloperidol) can increase your blood sugar and cholesterol. However, Haldol (Haloperidol) is less likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • Haldol (Haloperidol) can cause you to gain weight. However, Haldol (Haloperidol) is less likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  Sleep
                  SeroquelHaldol
                  • Can cause dizziness, drowsiness, and low blood pressure.
                  • It can cause dizziness, drowsiness, and can lower your blood pressure.
                  Weight
                  SeroquelHaldol
                  • Sometimes causes weight gain, sleepiness, and low blood pressure.
                  • May cause weight gain and worsen cholesterol or blood sugar.
                  • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • Less likely to cause weight gain and problems with cholesterol and blood sugar than most other antipsychotics.
                  • Haldol (Haloperidol) can cause you to gain weight. However, Haldol (Haloperidol) is less likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  Upsides and benefits
                  SeroquelHaldol
                  • Effective at relieving psychotic symptoms and manic episodes.
                  • Antipsychotic medicines are all about equally effective.
                  • Fewer side effects than most antipsychotic medicines.
                  • Less likely to cause heart problems compared to some antipsychotics.
                  • Compared to other antipsychotics, the least likely to cause Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
                  • Effective at relieving psychotic symptoms and agitation.
                  • Works just as well as other antipsychotic medicines.
                  • Less likely to cause weight gain and problems with cholesterol and blood sugar than most other antipsychotics.
                  Downsides and risks
                  SeroquelHaldol
                  • In studies, less effective for people over age 40 for schizophrenia.
                  • Sometimes causes weight gain, sleepiness, and low blood pressure.
                  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
                  • You might need routine blood tests to check how the medicine is affecting your body.
                  • It's an older medicine and has a lot more side effects than newer antipsychotics.
                  • Compared to other antipsychotics, it causes more hormone problems that can cause nipples to leak fluid, and sudden, dangerous abnormal heart rhythms.
                  • Has a higher risk of extrapyramidal symptoms (EPS): movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements. One of these symptoms (called tardive dyskinesia) is permanent and more likely if you take this medicine for many years.
                  • All antipsychotics have side effects that make them difficult to take. You might need to try a few different medicines until you find one that works best for you.
                  • You might need routine blood tests to check how the medicine is affecting your body.
                  Tips from our pharmacists for people taking the medication
                  SeroquelHaldol
                  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
                  • Can cause dizziness, drowsiness, and low blood pressure.
                  • For the first week, avoid activities that require you to be alert.
                  • May cause weight gain and worsen cholesterol or blood sugar.
                  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
                  • Elderly people with dementia shouldn't take it.
                  • It'll take 4 to 6 weeks to see the medication's full effects on your thoughts.
                  • It can cause dizziness, drowsiness, and can lower your blood pressure.
                  • For the first week, avoid activities like driving that require you to be alert.
                  • Immediately tell your doctor if you can't control your muscle movements or if you have a fever or excess sweating.
                  • Don't use in elderly people who have dementia.
                  • The oral liquid concentrate can be mixed with water or juice before taking it.
                  Learn more
                  More about SeroquelSide effectsReviews & ratingsAlternativesFDA package insert
                  Have you used Seroquel (Quetiapine)?
                  Worth itNot sureNot worth it
                  More about HaldolSide effectsReviews & ratingsAlternativesFDA package insert
                  Have you used Haldol (Haloperidol)?
                  Worth itNot sureNot worth it