Compare Seroquel vs. Invega

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Seroquel
(quetiapine)

Invega
(paliperidone)

Helps control your thoughts and mood. Seroquel (Quetiapine) is good for treating psychosis and mania. Fewer side effects than most antipsychotics, but might be less effective for people over age 40 with schizophrenia.Helps control your thoughts and mood. Invega (Paliperidone) is good for treating psychosis and improving mood. It's more likely to cause hormone problems than other antipsychotics.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5Seroquel
Reviews for Seroquel
56%
of people (All ages) say Seroquel is worth it
50%
say it works well
27%
say it's a big hassle
250 reviews
Have you used Seroquel (quetiapine)?
Worth itNot sureNot worth it
Reviews for Invega
29%
+27% better vs. Seroquel
32%
+18% better vs. Seroquel
35%
+8% better vs. Seroquel
Have you used Invega (paliperidone)?
Worth itNot sureNot worth it
Side effects
SeroquelInvega
  • Somnolence 42%
  • Dizziness 15%
  • Nausea 6%
  • Fatigue 5%
  • Increased Appetite 8%
  • Tachycardia 8%
  • Vomiting 4%
  • Dry Mouth 7%
  • Nasal Congestion 4%
  • Weight Increased 6%
More Seroquel side effects »
  • Tachycardia 5%
  • Somnolence 2%
  • Dizziness 1%
  • Abdominal pain upper 2%
  • Dry mouth 2%
  • Bundle branch block 1%
  • Fatigue 1%
More Invega side effects »
How it works
SeroquelInvega
Seroquel (Quetiapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Invega (Paliperidone) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affect your thoughts and mood.
Type of medication
SeroquelInvega
Prescription onlyPrescription only
Available as
SeroquelInvega
  • Pill
  • Extended release
  • Extended release
  • Injection
Used for
SeroquelInvega
Risk factors for serious side effects
SeroquelInvega
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Seroquel (quetiapine) risks & warnings »
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Invega (paliperidone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
SeroquelInvega
  • Seroquel (Quetiapine) can increase your blood sugar and cholesterol. Seroquel (Quetiapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Invega (Paliperidone) can increase your blood sugar and cholesterol. Invega (Paliperidone) is moderately likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
Sleep
SeroquelInvega
  • Can cause dizziness, drowsiness, and low blood pressure.
  • Can cause dizziness and drowsiness, or worsen you cholesterol and blood sugar levels.
Weight
SeroquelInvega
  • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Sometimes causes weight gain, sleepiness, and low blood pressure.
  • Invega (Paliperidone) can cause you to gain weight. Invega (Paliperidone) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Sometimes causes weight gain and low blood pressure.
Upsides and benefits
SeroquelInvega
  • Effective at relieving psychotic symptoms and manic episodes.
  • Antipsychotic medicines are all about equally effective.
  • Fewer side effects than most antipsychotic medicines.
  • Less likely to cause heart problems compared to some antipsychotics.
  • Compared to other antipsychotics, the least likely to cause Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • Effective at relieving psychotic symptoms and relapse rates for people with schizophrenia.
  • Also relieves psychotic symptoms and improves mood for people with schizoaffective disorder.
  • Works just as well as other antipsychotic medicines.
  • Less likely to cause heart or liver problems than some other antipsychotic medications.
Downsides and risks
SeroquelInvega
  • In studies, less effective for people over age 40 for schizophrenia.
  • Sometimes causes weight gain, sleepiness, and low blood pressure.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
  • Invega (Paliperidone) has a high risk of causing hormone problems that cause nipples to leak fluid and male breasts to grow abnormally large.
  • Sometimes causes weight gain and low blood pressure.
  • Mild risk of causing extrapyramidal symptoms (EPS): movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • Not a good choice for elderly people who have dementia.
  • All antipsychotics have side effects that make them difficult to take. You might need to try a few different medicines until you find one that works best for you.
Tips from our pharmacists for people taking the medication
SeroquelInvega
  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
  • Can cause dizziness, drowsiness, and low blood pressure.
  • For the first week, avoid activities that require you to be alert.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take it.
  • It'll take 4 to 6 weeks to see the medication's full effects on thoughts and mood.
  • Can cause dizziness and drowsiness, or worsen you cholesterol and blood sugar levels.
  • For the first week, avoid activities like driving that require you to be alert.
  • Don't worry if you see tablet shells in your stool since the medication was already absorbed by your body.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people who have dementia shouldn't take Invega (Paliperidone).
Learn more
More about SeroquelSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Seroquel (quetiapine)?
Worth itNot sureNot worth it
More about InvegaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Invega (paliperidone)?
Worth itNot sureNot worth it