Compare Seroquel vs. Saphris

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Seroquel
(Quetiapine)

Saphris
(Asenapine)

Helps control your thoughts and mood. Seroquel (Quetiapine) is good for treating psychosis and mania. Fewer side effects than most antipsychotics, but might be less effective for people over age 40 with schizophrenia.Coming soon.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.818627450980392Seroquel
Reviews for Seroquel (Quetiapine)
52%
of people say Seroquel (Quetiapine) is worth it
46%
say it works well
28%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
SeroquelSaphris
  • Drowsiness 42%
  • Dry mouth 31%
  • Dizziness 17%
  • Fatigue 10%
  • Increased appetite 9%
  • Headache 7%
  • Nausea 6%
  • Constipation 6%
  • Muscle weakness 6%
  • Positional low blood pressure 5%
More Seroquel side effects »

We haven’t found good data for Saphris side effects.

FDA side effect reports for Saphris »
How it works
SeroquelSaphris
Seroquel (Quetiapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Coming soon.
Type of medication
SeroquelSaphris
Antipsychotic
Atypical
Prescription only
Coming soon.
Available as
SeroquelSaphris
  • Pill
  • Extended release
  • Pill
Used for (click to learn more)
SeroquelSaphris
  • Bipolar I disorder
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Seroquel (Quetiapine)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Saphris (Asenapine)
Risk factors for serious side effects
SeroquelSaphris
  • Elderly patients with dementia
      • History of heart problems
      • Drug interactions
        • People with diabetes
        • People with high cholesterol
        • People with diabetes
        • Alcohol
        • Taking other medicines that make you less alert
          Detailed Seroquel (Quetiapine) risks & warnings »
          Coming soon.
          Pregnancy category
          SeroquelSaphris
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          • Seroquel (Quetiapine) can increase your blood sugar and cholesterol. Seroquel (Quetiapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
          • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
          No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          • Can cause dizziness, drowsiness, and low blood pressure.
          No specific sleep-related info.
          Weight
          • Sometimes causes weight gain, sleepiness, and low blood pressure.
          • May cause weight gain and worsen cholesterol or blood sugar.
          • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
          No specific weight-related info.
          Upsides and benefits
          SeroquelSaphris
          • Effective at relieving psychotic symptoms and manic episodes.
          • Antipsychotic medicines are all about equally effective.
          • Fewer side effects than most antipsychotic medicines.
          • Less likely to cause heart problems compared to some antipsychotics.
          • Compared to other antipsychotics, the least likely to cause Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
          Coming soon.
          Downsides and risks
          SeroquelSaphris
          • In studies, less effective for people over age 40 for schizophrenia.
          • Sometimes causes weight gain, sleepiness, and low blood pressure.
          • You might need routine blood tests to check how the medicine is affecting your body.
          • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
          Coming soon.
          Tips from our pharmacists for people taking the medication
          SeroquelSaphris
          • Takes 4 to 6 weeks to see full effects on thoughts and mood.
          • Can cause dizziness, drowsiness, and low blood pressure.
          • For the first week, avoid activities that require you to be alert.
          • May cause weight gain and worsen cholesterol or blood sugar.
          • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
          • Elderly people with dementia shouldn't take it.
          Coming soon.
          Learn more
          More about SeroquelSide effectsReviews & ratingsAlternativesFDA package insert
          More about SaphrisSide effectsReviews & ratingsFDA package insert