Compare Seroquel vs. Saphris

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Seroquel
(quetiapine)

Saphris
(asenapine)

Helps control your thoughts and mood. Seroquel (Quetiapine) is good for treating psychosis and mania. Fewer side effects than most antipsychotics, but might be less effective for people over age 40 with schizophrenia.Treats bipolar disorder and schizophrenia. While Saphris (asenapine) has fewer side effects compared with other medicines that treat bipolar disorder and schizophrenia, it can be more expensive.
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Prices and coupon for 30 (25mg) tablets of quetiapine
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Prices and coupon for 30 (10mg) orally disintegrating tabs of asenapine
Reviews & ratings
Filter group. All currently selected
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5Seroquel
Reviews for Seroquel (quetiapine)
56%
of people (All ages) say Seroquel (quetiapine) is worth it
50%
say it works well
27%
say it's a big hassle
250 reviews
Have you used Seroquel (quetiapine)?
Worth itNot sureNot worth it

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Have you used Saphris (asenapine)?
Worth itNot sureNot worth it
Side effects
SeroquelSaphris
  • Drowsiness 42%
  • Dizziness 15%
  • Nausea 6%
  • Fatigue 5%
  • Increased appetite 8%
  • Abnormally fast heart beat 8%
  • Vomiting 4%
  • Dry mouth 7%
  • Nasal congestion 4%
  • Weight increased 6%
More Seroquel side effects »
  • Trouble sleeping 2%
  • Sleepiness 6%
  • Difficulty controlling movements 3%
  • Restlessness 3%
  • Numbness in the mouth 4%
  • Dizziness 1%
  • Weight gain 2%
More Saphris side effects »
How it works
SeroquelSaphris
Seroquel (Quetiapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.While it's not clear how Saphris (asenapine) helps to treat bipolar disorder or schizophrenia, it changes the amount of dopamine and serotonin in the brain, two chemicals that are known to regulate mood.
Type of medication
SeroquelSaphris
Prescription only
Prescription only
Available as
SeroquelSaphris
  • Pill
  • Extended release
  • Dissolving pill
Used for
SeroquelSaphris
Risk factors for serious side effects
SeroquelSaphris
  • Elderly patients with dementia
      • History of heart problems
      • Drug interactions
        • People with diabetes
        • People with high cholesterol
        • People with diabetes
        • Alcohol
        • Taking other medicines that make you less alert
          Detailed Seroquel (quetiapine) risks & warnings »
          • People age 65 or older with dementia and psychosis
          • Taking antipsychotic medications
              • High blood pressure
              • History of heart disease
                Detailed Saphris (asenapine) risks & warnings »
                Pregnancy

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                Food
                SeroquelSaphris
                • Seroquel (Quetiapine) can increase your blood sugar and cholesterol. Seroquel (Quetiapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                No food related info.
                Sleep
                SeroquelSaphris
                • Can cause dizziness, drowsiness, and low blood pressure.
                No sleep related info.
                Weight
                SeroquelSaphris
                • Sometimes causes weight gain, sleepiness, and low blood pressure.
                • May cause weight gain and worsen cholesterol or blood sugar.
                • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                • People on medicines like Saphris (asenapine) have had weight gain and higher blood sugar to the point of having diabetes. Your doctor will work with you to stop that from happening.
                Upsides and benefits
                SeroquelSaphris
                • Effective at relieving psychotic symptoms and manic episodes.
                • Antipsychotic medicines are all about equally effective.
                • Fewer side effects than most antipsychotic medicines.
                • Less likely to cause heart problems compared to some antipsychotics.
                • Compared to other antipsychotics, the least likely to cause Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
                • Saphris (asenapine) can be used to treat bipolar disorder in children age 10 or older, and schizophrenia in children age 12 or older.
                • You don't need water to take Saphris (asenapine); the pill dissolves in your mouth right away.
                • Compared to other medicines, the side effects of Saphris (asenapine) are milder.
                Downsides and risks
                SeroquelSaphris
                • In studies, less effective for people over age 40 for schizophrenia.
                • Sometimes causes weight gain, sleepiness, and low blood pressure.
                • You might need routine blood tests to check how the medicine is affecting your body.
                • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
                • Saphris (asenapine) is only available as a brand name.
                • Compared to other medicines, Saphris (asenapine) can cause changes in your hormones and make you sleepy.
                • You have to take Saphris (asenapine) twice a day, which can be hard to remember.
                Tips from our pharmacists for people taking the medication
                SeroquelSaphris
                • Takes 4 to 6 weeks to see full effects on thoughts and mood.
                • Can cause dizziness, drowsiness, and low blood pressure.
                • For the first week, avoid activities that require you to be alert.
                • May cause weight gain and worsen cholesterol or blood sugar.
                • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
                • Elderly people with dementia shouldn't take it.
                • To take Saphris (asenapine), place the pill under your tongue and let it dissolve completely. Don't chew or swallow the pill, and don't eat or drink for 10 minutes after you take it.
                • You might feel numbness or tingling in your mouth or throat after you take Saphris (asenapine). This usually goes away after an hour.
                • Don't drive or do anything requiring concentration until you know how Saphris (asenapine) affects you.
                • Don't stop taking Saphris (asenapine) suddenly without talking to your doctor first because it can be very dangerous.
                • If you miss a dose of Saphris (asenapine), take it as soon as you remember, unless it’s time for your next dose; don't take 2 doses at the same time.
                • Keep Saphris (asenapine) in your pantry away from heat, moisture, and light. Don't store it in your bathroom's medicine cabinet.
                Learn more
                More about SeroquelSide effectsReviews & ratingsAlternativesFDA package insert
                Have you used Seroquel (quetiapine)?
                Worth itNot sureNot worth it
                More about SaphrisSide effectsReviews & ratingsAlternativesFDA package insert
                Have you used Saphris (asenapine)?
                Worth itNot sureNot worth it