Compare Seroquel vs. Saphris

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Seroquel (quetiapine)

Prescription only

Saphris (asenapine)

Prescription only
Helps control your thoughts and mood.

Seroquel (quetiapine) is a effective at treating schizophrenia, mania, and depression but it can cause weight gain and high blood glucose levels.

5.0/ 7 average rating with 250 reviewsforSeroquel
Treats bipolar disorder and schizophrenia.

While Saphris (asenapine) has fewer side effects compared with other medicines that treat bipolar disorder and schizophrenia, it can be more expensive.

Upsides
  • Seroquel (quetiapine) is effective at relieving psychotic symptoms and manic episodes.
  • Seroquel (quetiapine) has fewer side effects than most antipsychotic medications.
  • Seroquel (quetiapine) is less likely to cause heart problems compared to some other antipsychotics.
  • Seroquel (quetiapine) is also the least likely to cause Extrapyramidal Symptoms (EPS) – a movement disorder that causes stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • Saphris (asenapine) can be used to treat bipolar disorder in children age 10 or older, and schizophrenia in children age 12 or older.
  • You don't need water to take Saphris (asenapine); the pill dissolves in your mouth right away.
  • Compared to other medicines, the side effects of Saphris (asenapine) are milder.
Downsides
  • Seroquel (quetiapine) has a moderate to high risk of weight gain, elevated cholesterol and/or blood sugar compared to other antipsychotics.
  • You might need routine blood tests to check how Seroquel (quetiapine) is affecting your body.
  • Saphris (asenapine) is only available as a brand name.
  • Compared to other medicines, Saphris (asenapine) can cause changes in your hormones and make you sleepy.
  • You have to take Saphris (asenapine) twice a day, which can be hard to remember.
Used for
Dosage forms
  • Pill
  • Extended release
  • Dissolving pill
Price
Lowest price near you
$8.4
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Lowest price near you
$568.43
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Reviews
250 
56%
think this treatment is worth it
50%
think this treatment works well
27%
think this treatment is a hassle

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Side effects
10possible side effects
  • Drowsiness
    34%
  • Dry mouth
    19%
  • Headache
    17%
  • Weakness
    10%
  • Constipation
    10%
  • Dizziness
    9%
  • Tremor
    8%
  • Stomach pain
    7%
  • Low blood pressure
    7%
  • Agitation
    6%
See more detailed side effects
10possible side effects
  • Sleepiness
    22%
  • Trouble sleeping
    10%
  • Difficulty controlling movements
    6%
  • Numbness in the mouth
    5%
  • Fatigue
    4%
  • Dizziness
    4%
  • Indigestion
    3%
  • Swelling in the arms and legs
    3%
  • Weight gain
    3%
  • High blood pressure
    3%
See more detailed side effects
Risks and warnings
  • Higher risk of death

    Elderly patients with dementia-related psychosis

  • Suicidal thoughts or behavior

    Children, adolescents, and young adults (<24 years old)

  • Heart problems

    History of heart problems

    ...and 1 more risk factors

  • Metabolic changes (increased blood sugar, high cholesterol and weight gain)

    People with diabetes

    ...and 1 more risk factors

See more detailed risks and warnings
  • Higher risk of death

    People age 65 or older with dementia and psychosis

  • Neuroleptic malignant syndrome

    Taking antipsychotic medications

  • Changes in blood pressure and fainting

    High blood pressure

    ...and 1 more risk factors

See more detailed risks and warnings