Compare Seroquel vs. Zyprexa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Seroquel
(Quetiapine)

Zyprexa
(Olanzapine)

Helps control your thoughts and mood. Seroquel (Quetiapine) is good for treating psychosis and mania. Fewer side effects than most antipsychotics, but might be less effective for people over age 40 with schizophrenia.Helps control your thoughts and mood. Zyprexa (Olanzapine) is good for treating psychosis, mania, and agitation. More likely to cause weight gain and sleepiness than other antipsychotics.
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Reviews & ratings
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4.818627450980392Seroquel
Reviews for Seroquel (Quetiapine)
52%
of people (All ages) say Seroquel (Quetiapine) is worth it
46%
say it works well
28%
say it's a big hassle
204 reviews
Have you used Seroquel (Quetiapine)?
Worth itNot sureNot worth it
Reviews for Zyprexa (Olanzapine)
45%
7% vs. Seroquel (Quetiapine)
53%
+7% vs. Seroquel (Quetiapine)
47%
19% vs. Seroquel (Quetiapine)
Have you used Zyprexa (Olanzapine)?
Worth itNot sureNot worth it
Side effects
SeroquelZyprexa
  • Drowsiness 42%
  • Dry mouth 31%
  • Dizziness 17%
  • Fatigue 10%
  • Increased appetite 9%
  • Headache 7%
  • Nausea 6%
  • Constipation 6%
  • Muscle weakness 6%
  • Positional low blood pressure 5%
More Seroquel side effects »
  • Relaxation or sleepiness 39%
  • Increased appetite 25%
  • Weight increase 22%
  • Drowsiness 22%
  • Dry mouth 15%
  • Dizziness 12%
  • Muscle weakness 9%
  • Fatigue 8%
  • Constipation 6%
  • Indigestion 6%
More Zyprexa side effects »
How it works
SeroquelZyprexa
Seroquel (Quetiapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Zyprexa (Olanzapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.
Type of medication
SeroquelZyprexa
Antipsychotic
Atypical
Prescription only
Antipsychotic
Atypical
Prescription only
Available as
SeroquelZyprexa
  • Pill
  • Extended release
  • Pill
  • Dissolving tablet
  • Injection
Used for (click to learn more)
SeroquelZyprexa
Risk factors for serious side effects
SeroquelZyprexa
  • Elderly patients with dementia
      • History of heart problems
      • Drug interactions
        • People with diabetes
        • People with high cholesterol
        • People with diabetes
        • Alcohol
        • Taking other medicines that make you less alert
          Detailed Seroquel (Quetiapine) risks & warnings »
          • Elderly patients with dementia
              • History of heart problems
              • Drug interactions
                • People with diabetes
                • People with high cholesterol
                • People with diabetes
                • Alcohol
                • Taking other medicines that make you less alert
                  Detailed Zyprexa (Olanzapine) risks & warnings »
                  Pregnancy

                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  Food
                  SeroquelZyprexa
                  • Seroquel (Quetiapine) can increase your blood sugar and cholesterol. Seroquel (Quetiapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • Zyprexa (Olanzapine) can increase your blood sugar and cholesterol. Zyprexa (Olanzapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  Sleep
                  SeroquelZyprexa
                  • Can cause dizziness, drowsiness, and low blood pressure.
                  • Might make you more sleepy than some antipsychotics.
                  • Can cause dizziness and drowsiness.
                  Weight
                  SeroquelZyprexa
                  • Sometimes causes weight gain, sleepiness, and low blood pressure.
                  • May cause weight gain and worsen cholesterol or blood sugar.
                  • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
                  • May cause weight gain and worsen cholesterol or blood sugar.
                  • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  Upsides and benefits
                  SeroquelZyprexa
                  • Effective at relieving psychotic symptoms and manic episodes.
                  • Fewer side effects than most antipsychotic medicines.
                  • Less likely to cause heart problems compared to some antipsychotics.
                  • Compared to other antipsychotics, the least likely to cause Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
                  • Antipsychotic medicines are all about equally effective.
                  • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
                  • Lowers relapse rates for schizophrenia and bipolar disorder.
                  • Less likely to cause heart problems than some antipsychotics.
                  • Antipsychotic medicines are all about equally effective.
                  Downsides and risks
                  SeroquelZyprexa
                  • In studies, less effective for people over age 40 for schizophrenia.
                  • Sometimes causes weight gain, sleepiness, and low blood pressure.
                  • You might need routine blood tests to check how the medicine is affecting your body.
                  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
                  • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
                  • Might make you more sleepy than some antipsychotics.
                  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
                  • You might need routine blood tests to check how the medicine is affecting your body.
                  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
                  Tips from our pharmacists for people taking the medication
                  SeroquelZyprexa
                  • Can cause dizziness, drowsiness, and low blood pressure.
                  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
                  • For the first week, avoid activities that require you to be alert.
                  • May cause weight gain and worsen cholesterol or blood sugar.
                  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
                  • Elderly people with dementia shouldn't take it.
                  • Can cause dizziness and drowsiness.
                  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
                  • For the first week, avoid activities that require you to be alert.
                  • May cause weight gain and worsen cholesterol or blood sugar.
                  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
                  • Elderly people with dementia shouldn't take it.
                  Learn more
                  More about SeroquelSide effectsReviews & ratingsAlternativesFDA package insert
                  Have you used Seroquel (Quetiapine)?
                  Worth itNot sureNot worth it
                  More about ZyprexaSide effectsReviews & ratingsAlternativesFDA package insert
                  Have you used Zyprexa (Olanzapine)?
                  Worth itNot sureNot worth it