Compare nefazodone vs. Oleptro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Serzone
(nefazodone)

Oleptro
(trazodone)

Treats depression. Serzone (nefazodone) is usually used with other medicines to treat depression, but it is more likely to cause liver damage.Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.
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Coupons for nefazodone
Best available price for 60 (100mg) tablets of nefazodone
Coupons for Oleptro
Best available price for 30 (50mg) tablets of trazodone
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Serzone (nefazodone)
Not enough review data. Review it!
of people (All ages) say Serzone (nefazodone) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Serzone (nefazodone)?
Worth itNot sureNot worth it
Reviews for Oleptro (trazodone)
73%
+73% better vs. Serzone (nefazodone)
49%
+49% better vs. Serzone (nefazodone)
24%
-24% worse vs. Serzone (nefazodone)
Have you used Oleptro (trazodone)?
Worth itNot sureNot worth it
Side effects
nefazodoneOleptro
  • Headache 3%
  • Sleepiness 11%
  • Dry mouth 12%
  • Nausea 10%
  • Dizziness 12%
  • Constipation 6%
  • Weakness 6%
  • Trouble sleeping 2%
  • Lightheadedness 7%
  • Indigestion 2%
More nefazodone side effects »
  • Somnolence/sedation 27%
  • Drowsiness 21%
  • Dry mouth 14%
  • Headache 6%
  • Dizziness/lightheadedness 13%
  • Dizziness 13%
  • Nausea 8%
  • Fatigue 7%
More Oleptro side effects »
How it works
nefazodoneOleptro
Serzone (nefazodone) is a serotonin reuptake inhibitor. Serzone (nefazodone) raises the amount of serotonin in the brain, which helps to regulate your mood.Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
nefazodoneOleptro
Prescription only
Prescription only
Available as
nefazodoneOleptro
  • Pill
  • Pill
  • Extended release
Used for
nefazodoneOleptro
Risk factors for serious side effects
nefazodoneOleptro
  • People under age 24
  • Taking medicine for high blood pressure
  • History of seizures
  • History of heart attack or heart disease
  • Medicines that slow the heartbeat
Detailed Serzone (nefazodone) risks & warnings »
  • Age 24 years or younger
  • History of seizures
  • Alcoholism
  • Eating disorder
  • Higher dose
Detailed Oleptro (trazodone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
nefazodoneOleptro
  • Compared to other similar medicines, Serzone (nefazodone) has a lot of interactions with other drugs, so your doctor might have to adjust the doses of your other medicines.
No interactions related info.
Pain
nefazodoneOleptro
  • Talk to your doctor right away if you notice yellowing in the whites of your eyes or your skin, a high fever, pain in your stomach, or dark urine.
No pain related info.
Upsides and benefits
nefazodoneOleptro
  • Serzone (nefazodone) is a good choice to take with other medicines for depression if they haven't worked by themselves.
  • Serzone (nefazodone) is available in generic.
  • Commonly used in lower doses to help treat sleep problems (insomnia).
  • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
  • Fewer sexual side effects than many other antidepressants.
  • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
  • Comes as a generic medication and is cheaper than many other sleep aides.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides and risks
nefazodoneOleptro
  • While Serzone (nefazodone) is available as a generic, it's not considered a first or second choice medicine for depression because it is more likely to cause liver damage than other similar medicines.
  • Serzone (nefazodone) is usually taken 2 times a day; the first choice medicines are only taken 1 time a day.
  • It can take up to 3 months before you notice the full effects of Serzone (nefazodone).
  • Compared to other similar medicines, Serzone (nefazodone) has a lot of interactions with other drugs, so your doctor might have to adjust the doses of your other medicines.
  • Not as effective as other medications for depression.
  • More sedating than other antidepressants.
  • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Tips from our pharmacists for people taking the medication
nefazodoneOleptro
  • You may not notice any changes in your mood until you've taken Serzone (nefazodone) for at least 2 weeks. The full effects may not happen for at least 2 to 3 months.
  • Don't drive or do anything requiring concentration until you know how Serzone (nefazodone) affects you because it can make you feel dizzy.
  • If you forget a dose of Serzone (nefazodone), take it as soon as you remember. If it's time for your next dose, don't take 2 doses at the same time to make up for the missed dose.
  • Store Serzone (nefazodone) in your pantry away from heat, light, and moisture.
  • Talk to your doctor right away if you notice yellowing in the whites of your eyes or your skin, a high fever, pain in your stomach, or dark urine.
  • Makes you sleepy. Take at bedtime.
  • Can cause temporary dry mouth and upset stomach.
  • Seek medical attention for unwanted, persistent erection.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
Learn more
More about nefazodoneSide effectsAlternativesFDA package insert
Have you used Serzone (nefazodone)?
Worth itNot sureNot worth it
More about OleptroSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Oleptro (trazodone)?
Worth itNot sureNot worth it