Compare Serzone vs. Pristiq

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Serzone
(Nefazodone)

Pristiq
(Desvenlafaxine)

Coming soon.Improves mood. Pristiq (Desvenlafaxine) is basically the same medication as Effexor, which is cheaper because it's available as a generic.
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Reviews & ratings
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Reviews for Pristiq (Desvenlafaxine)
48%
+48% vs. Serzone (Nefazodone)
45%
+45% vs. Serzone (Nefazodone)
25%
25% vs. Serzone (Nefazodone)
Side effects
SerzonePristiq

We haven’t found good data for Serzone side effects.

FDA side effect reports for Serzone »
  • Nausea 31%
  • Excessive sweating 17%
  • Dry mouth 16%
  • Dizziness 11%
  • Constipation 10%
  • Impotence 10%
  • Sleep difficulty 9%
  • Decreased appetite 8%
  • Drowsiness 8%
  • Fatigue 7%
More Pristiq side effects »
How it works
SerzonePristiq
Coming soon.Pristiq (Desvenlafaxine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.
Type of medication
SerzonePristiq
Coming soon.
Antidepressant
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Prescription only
Available as
SerzonePristiq
  • Pill
  • Extended release
Used for (click to learn more)
SerzonePristiq
  • Major depressive disorder
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Serzone (Nefazodone)

After 4 weeks using Start and Pristiq (Desvenlafaxine), here’s how much better people feel.

Risk factors for serious side effects
SerzonePristiq
Coming soon.
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Pristiq (Desvenlafaxine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
    Detailed Pristiq (Desvenlafaxine) risks & warnings »
    Pregnancy category
    SerzonePristiq
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.
    Food
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.
    • Can cause sexual side effects (usually low libido or the inability to have an orgasm or ejaculate).
    • Pristiq (Desvenlafaxine) can cause lower sex drive or difficulty having an orgasm. If the problem persists after the first 2 to 3 months, you can talk to your doctor about alternative antidepressants or performance-enhancing medications.
    Sleep
    No specific sleep-related info.
    • Stopping Pristiq (Desvenlafaxine) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and dizziness. Withdrawal symptoms usually occur within 3 days of stopping the medication, and go away within 1 to 2 weeks. Work with your doctor to gradually reduce your dose.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    SerzonePristiq
    Coming soon.
    • Effective at relieving symptoms and lowering relapse rates for depression.
    • Six out of ten people who use an antidepressant for the first time find that it works for them.
    Downsides and risks
    SerzonePristiq
    Coming soon.
    • Similar to Effexor, without any extra benefits in clinical studies.
    • Can cause sexual side effects (usually low libido or the inability to have an orgasm or ejaculate).
    • Not available in generic form, so it's more expensive.
    • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
    • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
    Tips from our pharmacists for people taking the medication
    SerzonePristiq
    Coming soon.
    • Takes 8 to 12 weeks to see full effects on mood.
    • Can cause sweating and high blood pressure.
    • Stop taking slowly to avoid withdrawal symptoms.
    • Tell your doctor if you notice sudden mood changes or unusual thoughts.
    Learn more
    More about SerzoneSide effectsFDA package insert
    More about PristiqSide effectsReviews & ratingsAlternativesFDA package insert