Compare nefazodone vs. Pristiq

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Serzone
(nefazodone)

Pristiq
(desvenlafaxine)

Treats depression. Serzone (nefazodone) is usually used with other medicines to treat depression, but it is more likely to cause liver damage.Improves mood. Pristiq (Desvenlafaxine) is basically the same medication as Effexor, which is cheaper because it's available as a generic.
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Reviews & ratings
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Have you used Serzone (nefazodone)?
Worth itNot sureNot worth it
Reviews for Pristiq (desvenlafaxine)
53%
+53% better vs. Serzone (nefazodone)
49%
+49% better vs. Serzone (nefazodone)
23%
-23% worse vs. Serzone (nefazodone)
196 reviews
Have you used Pristiq (desvenlafaxine)?
Worth itNot sureNot worth it
Side effects
nefazodonePristiq
  • Headache 3%
  • Sleepiness 11%
  • Dry mouth 12%
  • Nausea 10%
  • Dizziness 12%
  • Constipation 6%
  • Weakness 6%
  • Trouble sleeping 2%
  • Lightheadedness 7%
  • Indigestion 2%
More nefazodone side effects »
  • Nausea 16%
  • Dry mouth 8%
  • Sleep difficulty 6%
  • Excessive sweating 7%
  • Dizziness 5%
  • Drowsiness 5%
  • Constipation 5%
  • Decreased appetite 6%
  • Fatigue 3%
  • Anxiety 3%
More Pristiq side effects »
How it works
nefazodonePristiq
Serzone (nefazodone) is a serotonin reuptake inhibitor. Serzone (nefazodone) raises the amount of serotonin in the brain, which helps to regulate your mood.Pristiq (Desvenlafaxine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.
Type of medication
nefazodonePristiq
Prescription only
Prescription only
Available as
nefazodonePristiq
  • Pill
  • Extended release
Used for
nefazodonePristiq
Risk factors for serious side effects
nefazodonePristiq
  • People under age 24
    • Taking medicine for high blood pressure
      • History of seizures
      • History of heart attack or heart disease
      • Medicines that slow the heartbeat
      Detailed Serzone (nefazodone) risks & warnings »
      • Age 24 years or younger
      • Using other medications that affect serotonin
      • Stopping Pristiq (Desvenlafaxine) suddenly
      • History of high blood pressure
      • Taking other blood-thinning drugs
        • History of bipolar disorder
        • At risk for bipolar disorder
        Detailed Pristiq (desvenlafaxine) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Interactions
        nefazodonePristiq
        • Compared to other similar medicines, Serzone (nefazodone) has a lot of interactions with other drugs, so your doctor might have to adjust the doses of your other medicines.
        No interactions related info.
        Pain
        nefazodonePristiq
        • Talk to your doctor right away if you notice yellowing in the whites of your eyes or your skin, a high fever, pain in your stomach, or dark urine.
        No pain related info.
        Upsides and benefits
        nefazodonePristiq
        • Serzone (nefazodone) is a good choice to take with other medicines for depression if they haven't worked by themselves.
        • Serzone (nefazodone) is available in generic.
        • Effective at relieving symptoms and lowering relapse rates for depression.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        Downsides and risks
        nefazodonePristiq
        • While Serzone (nefazodone) is available as a generic, it's not considered a first or second choice medicine for depression because it is more likely to cause liver damage than other similar medicines.
        • Serzone (nefazodone) is usually taken 2 times a day; the first choice medicines are only taken 1 time a day.
        • It can take up to 3 months before you notice the full effects of Serzone (nefazodone).
        • Compared to other similar medicines, Serzone (nefazodone) has a lot of interactions with other drugs, so your doctor might have to adjust the doses of your other medicines.
        • Similar to Effexor, without any extra benefits in clinical studies.
        • Can cause sexual side effects (usually low libido or the inability to have an orgasm or ejaculate).
        • Not available in generic form, so it's more expensive.
        • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        Tips from our pharmacists for people taking the medication
        nefazodonePristiq
        • You may not notice any changes in your mood until you've taken Serzone (nefazodone) for at least 2 weeks. The full effects may not happen for at least 2 to 3 months.
        • Don't drive or do anything requiring concentration until you know how Serzone (nefazodone) affects you because it can make you feel dizzy.
        • If you forget a dose of Serzone (nefazodone), take it as soon as you remember. If it's time for your next dose, don't take 2 doses at the same time to make up for the missed dose.
        • Store Serzone (nefazodone) in your pantry away from heat, light, and moisture.
        • Talk to your doctor right away if you notice yellowing in the whites of your eyes or your skin, a high fever, pain in your stomach, or dark urine.
        • Takes 8 to 12 weeks to see full effects on mood.
        • Can cause sweating and high blood pressure.
        • Stop taking slowly to avoid withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        Learn more
        More about nefazodoneSide effectsAlternativesFDA package insert
        Have you used Serzone (nefazodone)?
        Worth itNot sureNot worth it
        More about PristiqSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Pristiq (desvenlafaxine)?
        Worth itNot sureNot worth it