Compare Serzone vs. Zoloft

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Coming soon.

Serzone
(Nefazodone)

Zoloft
(Sertraline)

Coming soon.Improves mood and helps you relax. Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.
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Reviews & ratings
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Have you used Serzone (Nefazodone)?
Worth itNot sureNot worth it
Reviews for Zoloft (Sertraline)
59%
41% vs. Serzone (Nefazodone)
41%
59% vs. Serzone (Nefazodone)
15%
15% vs. Serzone (Nefazodone)
1472 reviews
Have you used Zoloft (Sertraline)?
Worth itNot sureNot worth it
Side effects
SerzoneZoloft

We haven’t found good data for Serzone side effects.

FDA side effect reports for Serzone »
  • Nausea 19%
  • Ejaculation failure 18%
  • Sleep difficulty 16%
  • Diarrhea/loose stools 14%
  • Fatigue 9%
  • Loss of appetite 9%
  • Lower sex drive 9%
  • Sweating increased 9%
  • Dizziness 8%
  • Indigestion 8%
More Zoloft side effects »
How it works
SerzoneZoloft
Coming soon.Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.
Type of medication
SerzoneZoloft
Coming soon.
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Available as
SerzoneZoloft
  • Pill
  • Pill
  • Liquid
Used for (click to learn more)
SerzoneZoloft
  • Major depressive disorder
Risk factors for serious side effects
SerzoneZoloft
  • Under 24 years old
  • Interactions with other medications
  • Stopping Zoloft (Sertraline) suddenly
  • Taking with blood-thinning drugs
  • Elderly
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
SerzoneZoloft
No interactions related info.
  • It interacts with St. John's Wort and Tryptophan.
Sex
SerzoneZoloft
No sex related info.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
Sleep
SerzoneZoloft
No sleep related info.
  • Causes less drowsiness than other antidepressants.
  • Zoloft (Sertraline) may increase the risk of low sodium levels in the blood (hyponatremia). Watch out for symptoms including headache, difficulty concentrating, memory problems, confusion, weakness, and unsteadiness, which may lead to falls. Talk to a doctor right away before developing more serious symptoms, such as hallucination, fainting, coma, and death.
Upsides and benefits
SerzoneZoloft
Coming soon
  • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
  • Causes less drowsiness than other antidepressants.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides and risks
SerzoneZoloft
Coming soon
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • More likely to cause diarrhea than other antidepressants.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Tips from our pharmacists for people taking the medication
SerzoneZoloft
Coming soon
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • It interacts with St. John's Wort and Tryptophan.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
Learn more
More about SerzoneSide effectsReviews & ratingsFDA package insert
Have you used Serzone (Nefazodone)?
Worth itNot sureNot worth it
More about ZoloftSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zoloft (Sertraline)?
Worth itNot sureNot worth it