Compare nefazodone vs. Zoloft

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Serzone (nefazodone)

Prescription only

Zoloft (sertraline)

Prescription only
Treats depression.

Serzone (nefazodone) is usually used with other medicines to treat depression, but it is more likely to cause liver damage.

Improves mood and helps you relax.

Zoloft (sertraline) is good for treating depression and anxiety, but it can interact with many medicines.

4.7/ 7 average rating with 1472 reviewsforZoloft
Upsides
  • Serzone (nefazodone) is a good choice to take with other medicines for depression if they haven't worked by themselves.
  • Serzone (nefazodone) is available in generic.
  • One of the more effective and better tolerated antidepressants in its class.
  • Causes less sleepiness than other antidepressants.
  • Available as a generic, which is cheaper.
  • Best choice among antidepressants if you are pregnant.
Downsides
  • While Serzone (nefazodone) is available as a generic, it's not considered a first or second choice medicine for depression because it is more likely to cause liver damage than other similar medicines.
  • Serzone (nefazodone) is usually taken 2 times a day; the first choice medicines are only taken 1 time a day.
  • It can take up to 3 months before you notice the full effects of Serzone (nefazodone).
  • Compared to other similar medicines, Serzone (nefazodone) has a lot of interactions with other drugs, so your doctor might have to adjust the doses of your other medicines.
  • Takes at least 1 to 2 weeks to kick in and can take up to 12 weeks for maximum effect.
  • Can cause low sex drive, an inability to orgasm or ejaculate, and minor weight gain (1 to 5 pounds).
  • Is more likely to cause diarrhea compared to other antidepressants.
  • Interacts with lots of other medicines.
  • You may need to try out several different antidepressants before you find the one that works for you.
Used for
Dosage forms
  • Pill
  • Pill
  • Liquid
Price
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$8.7
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Reviews
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1472 
59%
think this treatment is worth it
41%
think this treatment works well
15%
think this treatment is a hassle

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Side effects
10possible side effects
  • Headache
    36%
  • Dry mouth
    25%
  • Sleepiness
    25%
  • Nausea
    22%
  • Dizziness
    17%
  • Constipation
    14%
  • Weakness
    11%
  • Trouble sleeping
    11%
  • Lightheadedness
    10%
  • Indigestion
    9%
See more detailed side effects
10possible side effects
  • Nausea
    26%
  • Diarrhea
    18%
  • Dry mouth
    16%
  • Difficulty sleeping
    16%
  • Drowsiness
    13%
  • Dizziness
    12%
  • Tremor
    11%
  • Fatigue
    11%
  • More sweating
    8%
  • Constipation
    8%
See more detailed side effects
Risks and warnings
  • Higher risk of suicide

    People under age 24

  • Low blood pressure

    Taking medicine for high blood pressure

  • Seizures

    History of seizures

  • Lower heart rate

    History of heart attack or heart disease

    ...and 1 more risk factors

See more detailed risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Serotonin syndrome

    Taking other medicines that affect serotonin levels

  • Mania

    Personal history of bipolar disorder

    ...and 1 more risk factors

  • Withdrawal

    Stopping Zoloft (sertraline) suddenly

  • Increased bleeding

    Taking blood thinners

  • Low sodium levels in the blood

    Older people

    ...and 1 more risk factors

See more detailed risks and warnings