Compare Silenor vs. Pamelor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Silenor
(doxepin)

Pamelor
(nortriptyline)

Helps you relax, and sleep. Doxepin is a non-addictive way to help people stay asleep, but it comes with a list of side effects.Improves your mood. Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.
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Coupons for Silenor
Best available price for 30 (10mg) capsules of doxepin
Coupons for Pamelor
Best available price for 30 (10mg) capsules of nortriptyline
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Silenor (doxepin)
Not enough review data. Review it!
of people (All ages) say Silenor (doxepin) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Silenor (doxepin)?
Worth itNot sureNot worth it
Reviews for Pamelor (nortriptyline)
79%
-21% worse vs. Silenor (doxepin)
79%
+29% better vs. Silenor (doxepin)
21%
-21% worse vs. Silenor (doxepin)
Have you used Pamelor (nortriptyline)?
Worth itNot sureNot worth it
Side effects
SilenorPamelor

We haven’t found good data for Silenor side effects.

FDA side effect reports for Silenor »

We haven’t found good data for Pamelor side effects.

FDA side effect reports for Pamelor »
How it works
SilenorPamelor
Doxepin is a tricyclic antidepressant. It keeps norepinephrine and serotonin in your brain longer, helping you relax, and sleep. It also blocks the chemical that causes itch, and wakefulness.Pamelor (Nortriptyline) is a tricyclic antidepressant (TCA). It helps improve your mood by altering the levels of serotonin, norepinephrine, and other similar chemicals in your brain.
Type of medication
SilenorPamelor
Prescription only
Available as
SilenorPamelor
  • Pill
  • Liquid
  • Pill
  • Liquid
Used for
SilenorPamelor
  • Alcoholism Anxiety Depression Anxiety Depression Anxiety Depression Psychoneurotic Personality Disorder Insomnia Pruritus Moderate
Risk factors for serious side effects
SilenorPamelor
    Coming soon.
    • Age 24 years or younger
    • Age 65 years or older
    • Stopping Pamelor (Nortriptyline) suddenly
    • Using other medications that affect serotonin
    • History of heart disease
    Detailed Pamelor (nortriptyline) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Interactions
    SilenorPamelor
    • Doxepin can interact with many different medications, vitamins, and alternative treatments.
    No interactions related info.
    Alcohol
    SilenorPamelor
    • Stay away from alcohol while taking Doxepin, because it can slow your brain, and stop your breathing.
    No alcohol related info.
    Food
    SilenorPamelor
    No food related info.
    • Take it with food and/or at bedtime to decrease the potential side effects.
    Weight
    SilenorPamelor
    • Doxepin can increase your appetite, leading to weight gain.
    No weight related info.
    Upsides and benefits
    SilenorPamelor
    • In a clinical trial Doxepin was able to significantly improve sleep quality.
    • Doxepin helps improve your appetite, energy level, and sense of well-being, which increases your interests.
    • Once your body gets used to Doxepin, most of the side effects go away.
    • Doxepin comes in a generic form, so it is pretty cheap.
    • Doxepin is not addictive.
    • Helpful with treating certain types of pain, like migraines or nerve-related pain.
    • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
    Downsides and risks
    SilenorPamelor
    • Some people taking Doxepin walk, drive, eat, and have sex while sleeping. Be sure to tell your doctor if this happens to you.
    • Doxepin can increase your appetite, leading to weight gain.
    • Taking Doxepin can make emptying your bladder difficult.
    • Some people have suicidal thoughts when taking Doxepin.
    • Doxepin can interact with many different medications, vitamins, and alternative treatments.
    • Side effects are usually manageable, but can be annoying.
    • Increases the risk of falls, especially when used in the elderly.
    • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
    Tips from our pharmacists for people taking the medication
    SilenorPamelor
    • Take Doxepin 30 minutes before bedtime so it starts working when you get in bed.
    • Avoid activities that need you to be fully alert like driving, until you know how Doxepin affects you.
    • Follow up with your doctor so he or she can make sure Doxepin is the right medication for your depression.
    • Stay away from alcohol while taking Doxepin, because it can slow your brain, and stop your breathing.
    • Some people get dry mouth, or constipation when taking Doxepin. Sugar free gum or candy can help the dry mouth, and drinking more fluid can help with constipation.
    • Avoid direct sunlight while taking this medication. When you can’t avoid it, be sure to use sunscreen. It’s also important to put on a long-sleeved shirt, pants, hat, and sunglasses.
    • Needs to be taken every day for 1 to 2 weeks to start feeling better, and for 6 to 8 weeks to see the full effect of the medication.
    • It's important to keep taking Pamelor (Nortriptyline) even when you feel your symptoms are getting better.
    • Take it with food and/or at bedtime to decrease the potential side effects.
    • Tell your doctor if you notice sudden mood changes or unusual thoughts.
    • If you decide to stop taking Pamelor (Nortriptyline), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
    Learn more
    More about SilenorSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Silenor (doxepin)?
    Worth itNot sureNot worth it
    More about PamelorSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Pamelor (nortriptyline)?
    Worth itNot sureNot worth it