Compare Silenor vs. Surmontil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Silenor
(doxepin)

Surmontil
(trimipramine)

Helps you relax, and sleep. Doxepin is a non-addictive way to help people stay asleep, but it comes with a list of side effects.Improves your mood. Surmontil (trimipramine) is good at treating depression, but it can cause more side effects, like sleepiness and weight gain, compared to other medicines.
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Coupons for Silenor
Best available price for 30 (10mg) capsules of doxepin
Coupons for Surmontil
Best available price for 30 (100mg) capsules of trimipramine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Silenor (doxepin)
Not enough review data. Review it!
of people (All ages) say Silenor (doxepin) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Silenor (doxepin)?
Worth itNot sureNot worth it
Reviews for Surmontil (trimipramine)
Not enough review data. Review it!
-67% worse vs. Silenor (doxepin)
Not enough review data. Review it!
-17% worse vs. Silenor (doxepin)
Not enough review data. Review it!
Same vs. Silenor (doxepin)
Have you used Surmontil (trimipramine)?
Worth itNot sureNot worth it
Side effects
SilenorSurmontil

We haven’t found good data for Silenor side effects.

FDA side effect reports for Silenor »

The Surmontil FDA package insert doesn’t have numbers about how common side effects are.

More about Surmontil side effects »
How it works
SilenorSurmontil
Doxepin is a tricyclic antidepressant. It keeps norepinephrine and serotonin in your brain longer, helping you relax, and sleep. It also blocks the chemical that causes itch, and wakefulness.Surmontil (trimipramine) is a tricyclic antidepressant. It raises the amount of serotonin and norepinephrine in the brain, 2 chemicals that are known to regulate mood.
Type of medication
SilenorSurmontil
Prescription only
Available as
SilenorSurmontil
  • Pill
  • Liquid
  • Pill
Used for
SilenorSurmontil
  • Alcoholism Anxiety Depression Anxiety Depression Anxiety Depression Psychoneurotic Personality Disorder Insomnia Pruritus Moderate
Risk factors for serious side effects
SilenorSurmontil
    Coming soon.
    • People under age 24
    • Tricyclic antidepressants
    • Fentanyl
    • Tramadol
    • Buspirone
    Detailed Surmontil (trimipramine) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Interactions
    SilenorSurmontil
    • Doxepin can interact with many different medications, vitamins, and alternative treatments.
    No interactions related info.
    Alcohol
    SilenorSurmontil
    • Stay away from alcohol while taking Doxepin, because it can slow your brain, and stop your breathing.
    No alcohol related info.
    Food
    SilenorSurmontil
    No food related info.
    • Can be taken with or without food.
    Weight
    SilenorSurmontil
    • Doxepin can increase your appetite, leading to weight gain.
    No weight related info.
    Upsides and benefits
    SilenorSurmontil
    • In a clinical trial Doxepin was able to significantly improve sleep quality.
    • Doxepin helps improve your appetite, energy level, and sense of well-being, which increases your interests.
    • Once your body gets used to Doxepin, most of the side effects go away.
    • Doxepin comes in a generic form, so it is pretty cheap.
    • Doxepin is not addictive.
    • Surmontil (trimipramine) is part of the first choice medicines to treat depression.
    • Available in generic and in three different strengths.
    • Can be taken once a day, usually before you go to bed.
    • Can be taken with or without food.
    Downsides and risks
    SilenorSurmontil
    • Some people taking Doxepin walk, drive, eat, and have sex while sleeping. Be sure to tell your doctor if this happens to you.
    • Doxepin can increase your appetite, leading to weight gain.
    • Taking Doxepin can make emptying your bladder difficult.
    • Some people have suicidal thoughts when taking Doxepin.
    • Doxepin can interact with many different medications, vitamins, and alternative treatments.
    • You might not notice changes in your mood until you've taken Surmontil (trimipramine) for several weeks.
    • Stopping Surmontil (trimipramine) suddenly without telling your doctor can be dangerous.
    • Surmontil (trimipramine) can cause more side effects than other medicines used to treat depression.
    Tips from our pharmacists for people taking the medication
    SilenorSurmontil
    • Take Doxepin 30 minutes before bedtime so it starts working when you get in bed.
    • Avoid activities that need you to be fully alert like driving, until you know how Doxepin affects you.
    • Follow up with your doctor so he or she can make sure Doxepin is the right medication for your depression.
    • Stay away from alcohol while taking Doxepin, because it can slow your brain, and stop your breathing.
    • Some people get dry mouth, or constipation when taking Doxepin. Sugar free gum or candy can help the dry mouth, and drinking more fluid can help with constipation.
    • Avoid direct sunlight while taking this medication. When you can’t avoid it, be sure to use sunscreen. It’s also important to put on a long-sleeved shirt, pants, hat, and sunglasses.
    • Take Surmontil (trimipramine) at night since it can make you sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
    • If you forget a dose, take it as soon as you remember, unless it's time for your next dose. Don't take extra medicine to make up for the missed dose.
    • Don't stop taking Surmontil (trimipramine) without talking to your doctor first.
    • Be very careful getting up if you've been sitting or lying down for a while since you can feel dizzy.
    Learn more
    More about SilenorSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Silenor (doxepin)?
    Worth itNot sureNot worth it
    More about SurmontilSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Surmontil (trimipramine)?
    Worth itNot sureNot worth it