Compare Silenor vs. Tofranil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Silenor
(Doxepin)

Tofranil
(Imipramine Hydrochloride)

Helps you relax, and sleep. Doxepin is a non-addictive way to help people stay asleep, but it comes with a list of side effects.Coming soon.
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Reviews & ratings
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Have you used Silenor (Doxepin)?
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Have you used Tofranil (Imipramine Hydrochloride)?
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Side effects
SilenorTofranil

We haven’t found good data for Silenor side effects.

FDA side effect reports for Silenor »

We haven’t found good data for Tofranil side effects.

FDA side effect reports for Tofranil »
How it works
SilenorTofranil
Doxepin is a tricyclic antidepressant. It keeps norepinephrine and serotonin in your brain longer, helping you relax, and sleep. It also blocks the chemical that causes itch, and wakefulness.Coming soon.
Type of medication
SilenorTofranil
Available as
SilenorTofranil
  • Pill
  • Liquid
  • Pill
Used for
SilenorTofranil
  • Alcoholism Anxiety Depression Anxiety Depression Anxiety Depression Psychoneurotic Personality Disorder Insomnia Pruritus Moderate
  • Depression Nocturnal Enuresis
Risk factors for serious side effects
SilenorTofranil
Coming soon.Coming soon.
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Interactions
SilenorTofranil
  • Doxepin can interact with many different medications, vitamins, and alternative treatments.
No interactions related info.
Alcohol
SilenorTofranil
  • Stay away from alcohol while taking Doxepin, because it can slow your brain, and stop your breathing.
No alcohol related info.
Weight
SilenorTofranil
  • Doxepin can increase your appetite, leading to weight gain.
No weight related info.
Upsides and benefits
SilenorTofranil
  • In a clinical trial Doxepin was able to significantly improve sleep quality.
  • Doxepin helps improve your appetite, energy level, and sense of well-being, which increases your interests.
  • Once your body gets used to Doxepin, most of the side effects go away.
  • Doxepin comes in a generic form, so it is pretty cheap.
  • Doxepin is not addictive.
Coming soon
Downsides and risks
SilenorTofranil
  • Some people taking Doxepin walk, drive, eat, and have sex while sleeping. Be sure to tell your doctor if this happens to you.
  • Doxepin can increase your appetite, leading to weight gain.
  • Taking Doxepin can make emptying your bladder difficult.
  • Some people have suicidal thoughts when taking Doxepin.
  • Doxepin can interact with many different medications, vitamins, and alternative treatments.
Coming soon
Tips from our pharmacists for people taking the medication
SilenorTofranil
  • Take Doxepin 30 minutes before bedtime so it starts working when you get in bed.
  • Avoid activities that need you to be fully alert like driving, until you know how Doxepin affects you.
  • Follow up with your doctor so he or she can make sure Doxepin is the right medication for your depression.
  • Stay away from alcohol while taking Doxepin, because it can slow your brain, and stop your breathing.
  • Some people get dry mouth, or constipation when taking Doxepin. Sugar free gum or candy can help the dry mouth, and drinking more fluid can help with constipation.
  • Avoid direct sunlight while taking this medication. When you can’t avoid it, be sure to use sunscreen. It’s also important to put on a long-sleeved shirt, pants, hat, and sunglasses.
Coming soon
Learn more
More about SilenorSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Silenor (Doxepin)?
Worth itNot sureNot worth it
More about TofranilSide effectsReviews & ratingsFDA package insert
Have you used Tofranil (Imipramine Hydrochloride)?
Worth itNot sureNot worth it