Compare Silvadene vs. Bactroban

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Silvadene (Silver Sulfadiazine)

Bactroban (mupirocin)

Prescription only
No information currently available
Treats certain skin infections and kills bacteria in the nose.

Compared to over-the-counter first aid topical antibiotics, Bactroban (mupirocin) can kill a larger variety of bacteria and is a good alternative if you're allergic to certain ingredients in OTC products.

No information currently available
  • Can kill more types of bacteria than over-the-counter first aid topical antibiotics.
  • Works well at preventing resistant bacteria (bacteria that is hard to treat) in your nose from spreading to other areas.
  • Is generally a tolerable medicine. Few people experience side effects.
No information currently available
  • May be more expensive than some over-the-counter first-aid topical antibiotics.
  • You have to remember to apply this 3 times a day for skin infections, and 2 times a day for bacteria in the nose.
Used for
  • Burn
  • Impetigo
  • Secondary skin infections
  • MRSA colonization in the nostrils
Dosage forms
  • Cream, gel, or ointment
  • Cream
  • Ointment
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Side effects
The Silvadene (Silver Sulfadiazine) FDA package insert doesn’t have numbers about how common side effects are.
7possible side effects
  • Headache
  • Stuffy nose
  • Lung or breathing problems
  • Sore throat
  • Taste changes
  • Burning/ Stinging
  • Cough
See more detailed side effects
Risks and warnings
No information currently available
  • New bacteria or fungi

    Long-term use of Bactroban (mupirocin)

See more detailed risks and warnings