Compare Simvastatin vs. Antara

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zocor
(Simvastatin)

Antara
(Fenofibrate)

Lowers cholesterol. Zocor (Simvastatin) is a good medication to improve your cholesterol. Statin side effects can be difficult to deal with, but the benefits might outweigh the risks.Lowers cholesterol. Antara (Fenofibrate) is good for lowering triglycerides (fats), but it's not as good as statins for improving cholesterol.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.124573378839591Simvastatin
Reviews for Zocor (Simvastatin)
61%
of people say Zocor (Simvastatin) is worth it
48%
say it works well
14%
say it's a big hassle
Reviews for Antara (Fenofibrate)
27%
34% vs. Zocor (Simvastatin)
14%
34% vs. Zocor (Simvastatin)
29%
15% vs. Zocor (Simvastatin)
Side effects
SimvastatinAntara
  • Upset stomach 3%
  • Scaly, itchy rash 2%
  • Bronchitis 1%
  • Vertigo 1%
  • Muscle pain 1%
  • Edema/swelling 1%
  • Abnormal heart rhythm 1%
More Simvastatin side effects »
  • Abnormal liver function tests 7%
  • Increased ast 2%
  • Increased creatine phosphokinase 2%
  • Abdominal pain 1%
  • Inflammation inside the nose 1%
  • Constipation 1%
  • Increased alt 1%
More Antara side effects »
How it works
SimvastatinAntara
Zocor (Simvastatin) is cholesterol-lowering medicine called a statin. It lowers the amount of cholesterol your body makes, which helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).Antara (Fenofibrate) is a cholesterol-lowering medicine. It removes triglycerides from your body and makes it easier to process "bad" cholesterol (LDL). This also increases "good" cholesterol (HDL).
Type of medication
SimvastatinAntara
Cholesterol-lowering
Statin
Prescription only
Cholesterol-lowering
Fibric acid
Prescription only
Available as
SimvastatinAntara
  • Pill
  • Dissolving tablet
  • Pill
Used for (click to learn more)
SimvastatinAntara
Risk factors for serious side effects
SimvastatinAntara
  • Kidney disease
  • High dose of Zocor (Simvastatin)
  • Combining Zocor (Simvastatin) with certain cholesterol-lowering drugs
  • Older age and female gender
  • Heavy alcohol use
  • History of chronic liver disease
  • Pregnancy
  • Breast feeding
  • Certain drugs can increase the dose of Zocor (Simvastatin) in the body
    Detailed Zocor (Simvastatin) risks & warnings »
    • Taking Antara (Fenofibrate) with statins
    • Past history of liver disease
      • Taking Antara (Fenofibrate) with anticoagulants
              Detailed Antara (Fenofibrate) risks & warnings »
              Pregnancy category
              SimvastatinAntara
              XFDA pregnancy category (Unsafe)

              Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

              See the FDA package insert
              CFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              Alcohol
              • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
              • There are reports of liver damage in people who take Zocor (Simvastatin), especially if they are heavy alcohol drinkers or have a history of liver disease. If you notice dark urine or yellowing of the eyes or skin, tell your doctor. Your doctor may also want to check your liver function periodically.
              • Drinking large amounts of alcohol regularly can raise your risk of liver damage.
              • Don't drink a lot of alcohol while taking this medicine.
              Food
              No specific food-related info.No specific food-related info.
              Kidneys and liver
              • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
              • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
              • There are rare cases of muscle damage leading to kidney failure in people taking Zocor (Simvastatin). The risk is greater in people with kidney disease or thyroid disease, are older and female and taking certain cholesterol-lowering medication combinations. Tell your doctor if you develop sudden muscle pain, weakness or fever and there is no known cause.
              • Combining certain medications can increase the risk of muscle pain (myopathy), muscle damage (rhabdomyolysis) and kidney damage. Talk to your doctor or pharmacist when taking any new medications.
              • People on Antara (Fenofibrate) while taking statins have reported muscle pain which may lead to muscle and kidney damage. This has been very rare. Talk to your doctor if you develop sudden muscle pain or weakness or fever and you don't know why.
              Sex
              No specific sex-related info.No specific sex-related info.
              Sleep
              No specific sleep-related info.No specific sleep-related info.
              Weight
              No specific weight-related info.No specific weight-related info.
              Upsides and benefits
              SimvastatinAntara
              • Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
              • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
              • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
              Downsides and risks
              SimvastatinAntara
              • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
              • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
              • Not safe to use if you're pregnant.
              • In studies, it didn't lower heart disease in people with Type 2 diabetes.
              • According to new guidelines, you shouldn't take this medicine by itself to lower cholesterol.
              • Drinking large amounts of alcohol regularly can raise your risk of liver damage.
              • Different forms and strengths of this medication can't be substituted for each other.
              Tips from our pharmacists for people taking the medication
              SimvastatinAntara
              • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
              • Most people reach their target cholesterol levels in 4 to 6 weeks.
              • Avoid grapefruit and grapefruit juice while taking this medicine.
              • Tell your doctor if you develop sudden muscle pain, fever, or weakness.
              • Tell your doctor if you notice dark urine or yellowing of the eyes or skin.
              • Certain medications can interact with this drug. Talk to your doctor or pharmacist.
              • Lowers triglycerides.
              • Can cause backache or headache.
              • Call your doctor if you develop muscle or abdominal pain.
              • Don't drink a lot of alcohol while taking this medicine.
              • Also taking Welchol or Questran? Take this medicine at least 1 hour before or 6 hours after.
              • You should use this medicine in combination with a healthy diet.
              Learn more
              More about SimvastatinSide effectsReviews & ratingsAlternativesFDA package insert
              More about AntaraSide effectsReviews & ratingsAlternativesFDA package insert