Compare simvastatin vs. Antara

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zocor (simvastatin)

Prescription only

Antara (fenofibrate)

Prescription only
Lowers cholesterol.

Zocor (simvastatin) is a good medication to improve your cholesterol.

5.1/ 7 average rating with 1176 reviewsforsimvastatin
Lowers cholesterol and triglycerides.

Antara (fenofibrate) is effective at lowering triglyceride and cholesterol levels, but may cause liver problems and muscle pain.

3.3/ 7 average rating with 56 reviewsforAntara
  • Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
  • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Available in generic.
  • Available in combination pills with other cholesterol medicines.
  • Antara (fenofibrate) can reduce triglycerides by about 20-50%.
  • Although not as effective at lowering triglycerides, Antara (fenofibrate) can lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).
  • There is a less expensive generic version available.
  • You only need to take it once a day, with or without food.
  • You are at higher risk for side effects if you are female, are 65 years or older, drink alcohol every day, or have liver disease, kidney disease, or diabetes.
  • Not safe to use if you're pregnant.
  • Can have more drug interactions than some other drugs in the same class (statins).
  • Not as effective as statins in lowering cholesterol levels. You shouldn't take Antara (fenofibrate) by itself to lower cholesterol.
  • Drinking large amounts of alcohol regularly while taking Antara (fenofibrate) can increase your risk of liver damage.
  • Tell your doctor if you have a history of gallbladder, liver or kidney disease. Antara (fenofibrate) might not be the best choice to lower your triglyceride levels.
  • Antara (fenofibrate) can interact with other medications such as warfarin, colchicine, and sulfonylureas.
  • Antara (fenofibrate) was not shown to reduce rates of death in people with type 2 diabetes.
Used for
Dosage forms
  • Pill
  • Pill
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Side effects
The Zocor (simvastatin) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Abnormal liver function tests
  • Respiratory disorder
  • Stomach pain
  • Back pain
  • Headache
  • Increased AST
  • Increased ALT
  • Increased creatine phosphokinase
  • Nausea
  • Constipation
See more detailed side effects
Risks and warnings
  • Muscle pain and kidney damage

    Kidney disease

    ...and 4 more risk factors

  • Liver damage

    Heavy alcohol use

    ...and 1 more risk factors

  • Harm to unborn baby


    ...and 1 more risk factors

  • Drug interactions

    Certain drugs can increase the dose of Zocor (simvastatin) in the body

  • High blood sugar

    History of high blood sugar

See more detailed risks and warnings
  • Muscle pain

    Taking Antara (fenofibrate) with statins

    ...and 3 more risk factors

  • Liver damage

    History of liver disease

  • Gallstones

    History of gallstones

  • Increased bleeding risk

    Taking Antara (fenofibrate) with anticoagulants

See more detailed risks and warnings