Compare Simvastatin vs. Trilipix

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zocor
(Simvastatin)

Trilipix
(Fenofibric Acid)

Lowers cholesterol. Zocor (Simvastatin) is a good medication to improve your cholesterol. Statin side effects can be difficult to deal with, but the benefits might outweigh the risks.Lowers cholesterol. Trilipix is good for lowering triglycerides (fats), but it's not as good as statins for improving cholesterol and cardiovascular disease risk.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.124573378839591Simvastatin
Reviews for Zocor (Simvastatin)
61%
of people say Zocor (Simvastatin) is worth it
48%
say it works well
14%
say it's a big hassle
Reviews for Trilipix (Fenofibric Acid)
49%
12% vs. Zocor (Simvastatin)
22%
26% vs. Zocor (Simvastatin)
25%
11% vs. Zocor (Simvastatin)
Side effects
SimvastatinTrilipix
  • Upset stomach 3%
  • Scaly, itchy rash 2%
  • Bronchitis 1%
  • Vertigo 1%
  • Muscle pain 1%
  • Edema/swelling 1%
  • Abnormal heart rhythm 1%
More Simvastatin side effects »
  • Abnormal liver tests 7%
  • Increased creatine phosphokinase 2%
  • Abdominal pain 1%
  • Inflammation inside the nose 1%
  • Decreased liver function 1%
More Trilipix side effects »
How it works
SimvastatinTrilipix
Zocor (Simvastatin) is cholesterol-lowering medicine called a statin. It lowers the amount of cholesterol your body makes, which helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).Trilipix is a cholesterol-lowering medicine. It removes triglycerides from your body and makes it easier to process "bad" cholesterol (LDL). This also increases "good" cholesterol (HDL).
Type of medication
SimvastatinTrilipix
Cholesterol-lowering
Statin
Prescription only
Cholesterol-lowering
Fibric acid
Prescription only
Available as
SimvastatinTrilipix
  • Pill
  • Dissolving tablet
  • Pill
  • Extended release
Used for (click to learn more)
SimvastatinTrilipix
Risk factors for serious side effects
SimvastatinTrilipix
  • Kidney disease
  • High dose of Zocor (Simvastatin)
  • Combining Zocor (Simvastatin) with certain cholesterol-lowering drugs
  • Older age and female gender
  • Heavy alcohol use
  • History of chronic liver disease
  • Pregnancy
  • Breast feeding
  • Certain drugs can increase the dose of Zocor (Simvastatin) in the body
    Detailed Zocor (Simvastatin) risks & warnings »
    • Taking Trilipix (Fenofibric Acid) with statins
    • Past history of liver disease
      • Taking Trilipix (Fenofibric Acid) with anticoagulants
                Detailed Trilipix (Fenofibric Acid) risks & warnings »
                Pregnancy category
                SimvastatinTrilipix
                Alcohol
                • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
                • There are reports of liver damage in people who take Zocor (Simvastatin), especially if they are heavy alcohol drinkers or have a history of liver disease. If you notice dark urine or yellowing of the eyes or skin, tell your doctor. Your doctor may also want to check your liver function periodically.
                No specific alcohol-related info.
                Food
                No specific food-related info.No specific food-related info.
                Kidneys and liver
                • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
                • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
                • There are rare cases of muscle damage leading to kidney failure in people taking Zocor (Simvastatin). The risk is greater in people with kidney disease or thyroid disease, are older and female and taking certain cholesterol-lowering medication combinations. Tell your doctor if you develop sudden muscle pain, weakness or fever and there is no known cause.
                • Combining certain medications can increase the risk of muscle pain (myopathy), muscle damage (rhabdomyolysis) and kidney damage. Talk to your doctor or pharmacist when taking any new medications.
                • People on Trilipix (Fenofibric Acid) while taking statins have reported muscle pain which may lead to muscle and kidney damage. This has been very rare. Talk to your doctor if you develop sudden muscle pain or weakness or fever and you don't know why.
                Sex
                No specific sex-related info.No specific sex-related info.
                Sleep
                No specific sleep-related info.No specific sleep-related info.
                Weight
                No specific weight-related info.No specific weight-related info.
                Upsides and benefits
                SimvastatinTrilipix
                • Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
                • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
                • Good medicine for lowering triglycerides.
                • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
                Downsides and risks
                SimvastatinTrilipix
                • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
                • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
                • Not safe to use if you're pregnant.
                • In clinical studies, Trilipix hasn't lowered cholesterol or the risk of heart attack and stroke better than statins.
                • Different forms and strengths of this medication can't be substituted for each other.
                Tips from our pharmacists for people taking the medication
                SimvastatinTrilipix
                • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
                • Most people reach their target cholesterol levels in 4 to 6 weeks.
                • Avoid grapefruit and grapefruit juice while taking this medicine.
                • Tell your doctor if you develop sudden muscle pain, fever, or weakness.
                • Tell your doctor if you notice dark urine or yellowing of the eyes or skin.
                • Certain medications can interact with this drug. Talk to your doctor or pharmacist.
                • Can be used with other medications to help lower cholesterol.
                • Lowers triglycerides.
                • Can raise your chance of getting colds and flu.
                • Call your doctor if you develop muscle or abdominal pain.
                • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
                Learn more
                More about SimvastatinSide effectsReviews & ratingsAlternativesFDA package insert
                More about TrilipixSide effectsReviews & ratingsAlternativesFDA package insert