Compare Simvastatin vs. Vytorin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zocor
(Simvastatin)

Vytorin
(Ezetimibe / Simvastatin)

Lowers cholesterol. Zocor (Simvastatin) is a good medication to improve your cholesterol. Statin side effects can be difficult to deal with, but the benefits might outweigh the risks.Lowers cholesterol. Vytorin is expensive and is no more effective than simvastatin by itself.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.13Simvastatin
Reviews for Zocor (Simvastatin)
61%
of people (All ages) say Zocor (Simvastatin) is worth it
48%
say it works well
14%
say it's a big hassle
1176 reviews
Have you used Zocor (Simvastatin)?
Worth itNot sureNot worth it
Reviews for Vytorin (Ezetimibe / Simvastatin)
53%
8% vs. Zocor (Simvastatin)
36%
12% vs. Zocor (Simvastatin)
19%
5% vs. Zocor (Simvastatin)
Have you used Vytorin (Ezetimibe / Simvastatin)?
Worth itNot sureNot worth it
Side effects
SimvastatinVytorin

The Simvastatin FDA package insert doesn’t have numbers about how common side effects are.

More about Simvastatin side effects »
  • Unexplained muscle pain or weakness 1%
More Vytorin side effects »
How it works
SimvastatinVytorin
Zocor (Simvastatin) is cholesterol-lowering medicine called a statin. It lowers the amount of cholesterol your body makes, which helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).Vytorin is a combination cholesterol-lowering medicine. Simvastatin prevents your body from making "bad" cholesterol (LDL) while raising "good" cholesterol (HDL). Ezetimibe prevents cholesterol absorption in your intestines.
Type of medication
SimvastatinVytorin
Cholesterol-lowering
Statin
Prescription only
Cholesterol-lowering
Cholesterol inhibitor
Statin
Prescription only
Available as
SimvastatinVytorin
  • Pill
  • Dissolving tablet
  • Pill
Used for (click to learn more)
SimvastatinVytorin
Risk factors for serious side effects
SimvastatinVytorin
  • Kidney disease
  • High dose of Zocor (Simvastatin)
  • Combining Zocor (Simvastatin) with certain cholesterol-lowering drugs
  • Older age and female gender
  • Heavy alcohol use
Detailed risks & warnings »
  • Asian patients taking high-dose niacin
  • Past history of liver disease
  • heavy alcohol use
  • Diabetes
  • Pregnancy
Detailed risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Interactions
SimvastatinVytorin
  • Certain medications can interact with this drug. Talk to your doctor or pharmacist.
No interactions related info.
Alcohol
SimvastatinVytorin
  • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
No alcohol related info.
Kidneys and liver
SimvastatinVytorin
  • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
  • There are rare cases of muscle damage leading to kidney failure in people taking Zocor (Simvastatin). The risk is greater in people with kidney disease or thyroid disease, are older and female and taking certain cholesterol-lowering medication combinations. Tell your doctor if you develop sudden muscle pain, weakness or fever and there is no known cause.
  • There are reports of liver damage in people who take Zocor (Simvastatin), especially if they are heavy alcohol drinkers or have a history of liver disease. If you notice dark urine or yellowing of the eyes or skin, tell your doctor. Your doctor may also want to check your liver function periodically.
  • People on Vytorin (Ezetimibe / Simvastatin) have reported muscle pain which may lead to muscle breakdown and kidney damage, especially in people of Asian ancestry who are also taking niacin. This has been very rare. Talk to your doctor if you suddenly develop muscle pain and a fever and you don't know why.
Pain
SimvastatinVytorin
  • Combining certain medications can increase the risk of muscle pain (myopathy), muscle damage (rhabdomyolysis) and kidney damage. Talk to your doctor or pharmacist when taking any new medications.
No pain related info.
Upsides and benefits
SimvastatinVytorin
  • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
  • A 2-in-1 cholesterol-lowering combination medicine.
  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
Downsides and risks
SimvastatinVytorin
  • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
  • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
  • Not safe to use if you're pregnant.
  • In clinical studies, simvastatin/ezetimibe hasn't controlled cholesterol better than simvastatin alone.
  • There's no generic available, so it can be expensive.
Tips from our pharmacists for people taking the medication
SimvastatinVytorin
  • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
  • Most people reach their target cholesterol levels in 4 to 6 weeks.
  • Tell your doctor if you develop sudden muscle pain, fever, or weakness.
  • Tell your doctor if you notice dark urine or yellowing of the eyes or skin.
  • Certain medications can interact with this drug. Talk to your doctor or pharmacist.
  • Avoid grapefruit and grapefruit juice while taking this medicine.
  • Take it in the evening.
  • Can cause headaches or diarrhea.
  • Call your doctor if you develop muscle pain.
  • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
  • Avoid grapefruit and grapefruit juice while taking this medicine.
Learn more
More about SimvastatinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zocor (Simvastatin)?
Worth itNot sureNot worth it
More about VytorinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Vytorin (Ezetimibe / Simvastatin)?
Worth itNot sureNot worth it