Compare Simvastatin vs. Zetia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zocor
(simvastatin)

Zetia
(ezetimibe)

Lowers cholesterol. Zocor (Simvastatin) is a good medication to improve your cholesterol. Statin side effects can be difficult to deal with, but the benefits might outweigh the risks.Lowers cholesterol. Zetia (ezetimibe) can improve your cholesterol and can be used as an alternative to statins.
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Coupons for Simvastatin
Best available price for 30 (20mg) tablets of simvastatin
Coupons for Zetia
Best available price for 30 (10mg) tablets of ezetimibe
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.13Simvastatin
Reviews for Zocor (simvastatin)
61%
of people (All ages) say Zocor (simvastatin) is worth it
48%
say it works well
14%
say it's a big hassle
1176 reviews
Have you used Zocor (simvastatin)?
Worth itNot sureNot worth it
Reviews for Zetia (ezetimibe)
42%
-19% worse vs. Zocor (simvastatin)
34%
-14% worse vs. Zocor (simvastatin)
21%
-7% worse vs. Zocor (simvastatin)
128 reviews
Have you used Zetia (ezetimibe)?
Worth itNot sureNot worth it
Side effects
SimvastatinZetia
  • Upper respiratory infections 9%
  • Abdominal pain 7%
  • Constipation 7%
  • Headache 7%
  • Bronchitis 1%
  • Abnormal heart rhythm 1%
  • Nausea 5%
  • Scaly, itchy rash 2%
  • Upset stomach 3%
  • Vertigo 1%
More Simvastatin side effects »
  • Common cold 1%
  • Sore throat 4%
  • Sinus infection 1%
  • Abnormal liver tests 3%
  • Joint pain 1%
  • Pain in arms and legs 1%
  • Muscle pain 3%
More Zetia side effects »
How it works
SimvastatinZetia
Zocor (Simvastatin) is cholesterol-lowering medicine called a statin. It lowers the amount of cholesterol your body makes, which helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).Zetia (ezetimibe) is a cholesterol-lowering medicine. It stops your body from absorbing cholesterol in food and helps process other forms of cholesterol.
Type of medication
SimvastatinZetia
Prescription only
Prescription only
Available as
SimvastatinZetia
  • Pill
  • Dissolving tablet
  • Pill
Used for
SimvastatinZetia
Risk factors for serious side effects
SimvastatinZetia
  • Kidney disease
  • High dose of Zocor (Simvastatin)
  • Combining Zocor (Simvastatin) with certain cholesterol-lowering drugs
  • Older age and female gender
  • Heavy alcohol use
Detailed Zocor (simvastatin) risks & warnings »
  • Taking Zetia (ezetimibe) with statins
  • Past history of liver disease
Detailed Zetia (ezetimibe) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
SimvastatinZetia
  • Certain medications can interact with this drug. Talk to your doctor or pharmacist.
No interactions related info.
Alcohol
SimvastatinZetia
  • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
No alcohol related info.
Kidneys and liver
SimvastatinZetia
  • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
  • There are rare cases of muscle damage leading to kidney failure in people taking Zocor (Simvastatin). The risk is greater in people with kidney disease or thyroid disease, are older and female and taking certain cholesterol-lowering medication combinations. Tell your doctor if you develop sudden muscle pain, weakness or fever and there is no known cause.
  • There are reports of liver damage in people who take Zocor (Simvastatin), especially if they are heavy alcohol drinkers or have a history of liver disease. If you notice dark urine or yellowing of the eyes or skin, tell your doctor. Your doctor may also want to check your liver function periodically.
  • Zetia (ezetimibe) can hurt your liver, especially if it is used with statins. Talk to your doctor if you have liver disease.
Pain
SimvastatinZetia
  • Combining certain medications can increase the risk of muscle pain (myopathy), muscle damage (rhabdomyolysis) and kidney damage. Talk to your doctor or pharmacist when taking any new medications.
  • Zetia (ezetimibe) can hurt your liver, especially if it is used with statins. Talk to your doctor if you have liver disease.
Upsides and benefits
SimvastatinZetia
  • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Can be used with other medicines to improve cholesterol.
  • Available in a combination pill with simvastatin.
  • Available as a generic.
Downsides and risks
SimvastatinZetia
  • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
  • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
  • Not safe to use if you're pregnant.
  • Doesn't lower triglycerides (fats).
  • Hasn't been shown to lower the risk of heart attacks or heart disease.
  • By itself, it isn't as effective as statins for improving cholesterol.
Tips from our pharmacists for people taking the medication
SimvastatinZetia
  • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
  • Most people reach their target cholesterol levels in 4 to 6 weeks.
  • Avoid grapefruit and grapefruit juice while taking this medicine.
  • Tell your doctor if you develop sudden muscle pain, fever, or weakness.
  • Tell your doctor if you notice dark urine or yellowing of the eyes or skin.
  • Certain medications can interact with this drug. Talk to your doctor or pharmacist.
  • Lowers bad cholesterol and raises good cholesterol.
  • Tell your doctor if you develop bone or muscle pain.
  • Can be used with other medications to lower cholesterol.
  • Good alternative to statins if you can't tolerate statins or are unable to control cholesterol with statins alone.
  • Can cause diarrhea or increase your chance of getting colds.
Learn more
More about SimvastatinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zocor (simvastatin)?
Worth itNot sureNot worth it
More about ZetiaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zetia (ezetimibe)?
Worth itNot sureNot worth it