Compare Skelaxin vs. Norflex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Skelaxin
(metaxalone)

Norflex
(orphenadrine)

Relaxes your muscles. Skelaxin (metaxalone) is used for muscle spasms and musculoskeletal pain with mixed results.Coming soon.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Skelaxin (metaxalone)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Norflex (orphenadrine)?
Worth itNot sureNot worth it
Side effects
SkelaxinNorflex

The Skelaxin FDA package insert doesn’t have numbers about how common side effects are.

More about Skelaxin side effects »

We haven’t found good data for Norflex side effects.

FDA side effect reports for Norflex »
How it works
SkelaxinNorflex
How Skelaxin (metaxalone) works is not exactly known. It is believed that it works on the brain to help relieve muscle pain and relax muscles.Coming soon.
Type of medication
SkelaxinNorflex
Available as
SkelaxinNorflex
  • Pill
  • Extended release
Used for
SkelaxinNorflex
  • Musculoskeletal Pain
  • Musculoskeletal Pain
Risk factors for serious side effects
SkelaxinNorflex
  • Taking other medications that also cause sleepiness
  • Recreational drug use
  • Excessive alcohol use
  • Taking antidepressants
  • Higher than recommended doses of Skelaxin (metaxalone)
Detailed Skelaxin (metaxalone) risks & warnings »
    Coming soon.
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Food
    SkelaxinNorflex
    • Can be taken with or without food. However, Skelaxin (metaxalone) may be stronger when taken with food, especially if you are older. Be on the lookout for more pronounced drowsiness or sleepiness.
    No food related info.
    Kidneys and liver
    SkelaxinNorflex
    • People who have any liver or kidney problems should not use Skelaxin (metaxalone). Skelaxin (metaxalone) is broken down by the liver, and eliminated from the body via the kidneys. If either of those are not working at their best, you could have high levels of Skelaxin (metaxalone) in your body and more side effects.Your liver could also worsen. Talk to your doctor as you may need to get routine blood test for your liver and kidneys if you already have liver/kidney problems.
    No kidneys and liver related info.
    Sleep
    SkelaxinNorflex
    • Taking Skelaxin (metaxalone) with alcohol or narcotics can worsen the drowsiness.
    • Can make you very drowsy or sleepy
    No sleep related info.
    Upsides and benefits
    SkelaxinNorflex
    • Can be used for muscle spasms and muscle pain if other medications have not worked.
    • Available as generic.
    • Slightly less sedation and side effects compared to other muscle relaxants.
    Coming soon
    Downsides and risks
    SkelaxinNorflex
    • Effects don't last that long. You need to take Skelaxin (metaxalone) up to 3-4 times daily.
    • Several studies showed mixed results when Skelaxin (metaxalone) was compared with a sugar pill for treatment of muscle spasms and musculoskeletal pain.
    • Can make you very drowsy or sleepy
    • Even though a generic is available, it is still fairly expensive.
    Coming soon
    Tips from our pharmacists for people taking the medication
    SkelaxinNorflex
    • Can be taken with or without food. However, Skelaxin (metaxalone) may be stronger when taken with food, especially if you are older. Be on the lookout for more pronounced drowsiness or sleepiness.
    • Skelaxin (metaxalone) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
    • Taking Skelaxin (metaxalone) with alcohol or narcotics can worsen the drowsiness.
    • Skelaxin (metaxalone) can also have a more pronounced effect on women.
    Coming soon
    Learn more
    More about SkelaxinSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Skelaxin (metaxalone)?
    Worth itNot sureNot worth it
    More about NorflexSide effectsReviews & ratingsFDA package insert
    Have you used Norflex (orphenadrine)?
    Worth itNot sureNot worth it