Compare Skelaxin vs. Norflex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relaxes your muscles.

Skelaxin (metaxalone) is used for muscle spasms and musculoskeletal pain with mixed results.

No information currently available
Upsides
  • Can be used for muscle spasms and muscle pain if other medications have not worked.
  • Available as generic.
  • Slightly less sedation and side effects compared to other muscle relaxants.
No information currently available
Downsides
  • Effects don't last that long. You need to take Skelaxin (metaxalone) up to 3-4 times daily.
  • Several studies showed mixed results when Skelaxin (metaxalone) was compared with a sugar pill for treatment of muscle spasms and musculoskeletal pain.
  • Can make you very drowsy or sleepy
  • Even though a generic is available, it is still fairly expensive.
No information currently available
Used for
  • Musculoskeletal pain
  • Musculoskeletal pain
Dosage forms
  • Pill
  • Extended release
Price
No pricing information available
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Reviews
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Side effects
The Skelaxin (metaxalone) FDA package insert doesn’t have numbers about how common side effects are.
The Norflex (Orphenadrine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Sleepiness and dizziness
    • Taking other medications that also cause sleepiness
    • Recreational drug use
    • Excessive alcohol use
  • Serotonin syndrome
    • Taking antidepressants
    • Higher than recommended doses of Skelaxin (metaxalone)
  • Liver damage
    • History of liver disease
  • Liver or Kidney problems
    • History of liver disease
    • History of kidney disease
See more detailed risks and warnings
No information currently available