Compare Skelaxin vs. Zanaflex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Skelaxin
(Metaxalone)

Zanaflex
(Tizanidine)

Coming soon.Relaxes your muscles. Zanaflex (Tizanidine) isn't a first-choice treatment for muscle spasms. Try other options before using this.
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Reviews & ratings
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Have you used Skelaxin (Metaxalone)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Zanaflex (Tizanidine)?
Worth itNot sureNot worth it
Side effects
SkelaxinZanaflex

We haven’t found good data for Skelaxin side effects.

FDA side effect reports for Skelaxin »

We haven’t found good data for Zanaflex side effects.

FDA side effect reports for Zanaflex »
How it works
SkelaxinZanaflex
Coming soon.Zanaflex (Tizanidine) is a muscle relaxer. It works in the nervous system to calm down muscle spasms without interfering with normal muscle function.
Type of medication
SkelaxinZanaflex
Prescription only
Available as
SkelaxinZanaflex
  • Pill
  • Pill
Used for
SkelaxinZanaflex
  • Musculoskeletal Pain
Risk factors for serious side effects
SkelaxinZanaflex
Coming soon.
    • Age 65 years or older
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
      Detailed Zanaflex (Tizanidine) risks & warnings »
      Pregnancy

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Alcohol
      SkelaxinZanaflex
      No alcohol related info.
      • Don't drink alcohol while using this.
      Food
      SkelaxinZanaflex
      No food related info.
      • Can be taken with or without food, but you need to be consistent in how you take it every day.
      • Need to be consistent every day in taking this with or without food.
      • Can be taken with or without food, but you need to be consistent since food affects how the medication is absorbed and works.
      Sleep
      SkelaxinZanaflex
      No sleep related info.
      • Can cause dizziness, fatigue, drowsiness, and dry mouth.
      • Can cause extreme drowsiness or dizziness if you are taking meds for high blood pressure.
      Upsides and benefits
      SkelaxinZanaflex
      Coming soon
      • Relieves muscle spasms well.
      • Can be taken with or without food, but you need to be consistent in how you take it every day.
      • Available as a generic.
      • Available in a tablet or capsule form. It also comes in a capsule that can be opened and sprinkled in applesauce for people that can't swallow pills.
      Downsides and risks
      SkelaxinZanaflex
      Coming soon
      • This isn't a first-choice muscle relaxing medication. Other drugs work better and have fewer side effects.
      • Zanaflex (Tizanidine) can lower blood pressure, so be careful if you are already on a blood pressure medication.
      • Need to be consistent every day in taking this with or without food.
      • Elderly individuals have more side effects when taking Zanaflex (Tizanidine).
      • Can't stop taking this abruptly if you use it regularly.
      Tips from our pharmacists for people taking the medication
      SkelaxinZanaflex
      Coming soon
      • Can cause dizziness, fatigue, drowsiness, and dry mouth.
      • Avoid activities requiring mental alertness (like driving) until you know how it affects you.
      • Can cause extreme drowsiness or dizziness if you are taking meds for high blood pressure.
      • Side effects are more prevalent in the elderly.
      • Don't drink alcohol while using this.
      • Can be taken with or without food, but you need to be consistent since food affects how the medication is absorbed and works.
      Learn more
      More about SkelaxinSide effectsReviews & ratingsFDA package insert
      Have you used Skelaxin (Metaxalone)?
      Worth itNot sureNot worth it
      More about ZanaflexSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Zanaflex (Tizanidine)?
      Worth itNot sureNot worth it