Compare Soma vs. baclofen

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Soma
(carisoprodol)

Lioresal
(baclofen)

Relaxes your muscles. Soma (carisoprodol) is used for muscle spasms and muscle pain but it's not considered a first-choice treatment and not meant for long-term therapy.Relaxes your muscles. Lioresal (baclofen) is a first choice treatment for muscle spasticity caused by multiple sclerosis or spinal cord injuries, but it's not recommended for other types of muscle spasms.
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Coupons for Soma
Best available price for 90 (350mg) tablets of soma
Coupons for baclofen
Best available price for 90 (10mg) tablets of baclofen
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.74Soma
Reviews for Soma
61%
of people (All ages) say Soma is worth it
39%
say it works well
9%
say it's a big hassle
220 reviews
Have you used Soma (carisoprodol)?
Worth itNot sureNot worth it
Reviews for baclofen
61%
Same vs. Soma
55%
-16% worse vs. Soma
15%
+6% better vs. Soma
Have you used Lioresal (baclofen)?
Worth itNot sureNot worth it
Side effects
Somabaclofen
  • Drowsiness 7%
  • Dizziness 6%
  • Headache 3%
More Soma side effects »
  • Drowsiness 27%
More baclofen side effects »
How it works
Somabaclofen
Soma (carisoprodol) is a muscle relaxant. It works in the brain to help calm down muscle spasms.Lioresal (baclofen) is a gamma-aminobutryic acid (GABA) agonist. It's not clear how it works, but GABA is believed to help calm down nerves. Muscle spasms are thought to be started by overactive nerves.
Type of medication
Somabaclofen
Prescription onlyPrescription only
Available as
Somabaclofen
  • Pill
  • Pill
Used for
Somabaclofen
Risk factors for serious side effects
Somabaclofen
  • Taking other medications that also cause sleepiness
  • Recreational drug use
  • Excessive alcohol use
  • Elderly
  • Prior history of drug abuse
Detailed Soma (carisoprodol) risks & warnings »
  • Stopping Lioresal (baclofen) too quickly
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
  • Higher dose
Detailed Lioresal (baclofen) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
Somabaclofen
  • Don't drink alcohol while on this medication.
  • Avoid drinking alcohol while on Lioresal (baclofen) because it can make you very sleepy or slow your breathing down.
Sleep
Somabaclofen
No sleep related info.
  • Lioresal (baclofen) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
Upsides and benefits
Somabaclofen
  • Patients treated with Soma (carisoprodol) experienced improvement in function.
  • Available in generic.
  • Available in two different strengths.
  • A better option for seniors compared to other muscle relaxants since it has fewer side effects than other similar medicines.
  • Lioresal (baclofen) is available as a generic and is a relatively inexpensive medication.
Downsides and risks
Somabaclofen
  • Not first choice for treating muscle spasms or muscle pain, because it can cause dependence.
  • Can cause dizziness and sleepiness.
  • Not meant for long-term therapy, because it hasn't been shown to be effective after taking it for a short period.
  • Can cause withdrawal symptoms if you stop taking it suddenly.
  • Except for specific muscle spasms caused by brain injury or multiple sclerosis, Lioresal (baclofen) is not a recommended medicine.
  • If you've been taking Lioresal (baclofen) regularly for a long time, you'll need to get off of it slowly.
  • Lioresal (baclofen) can make you sleepy.
  • If you've had a stroke, Lioresal (baclofen) may not work as well, and you're more likely to experience side effects.
Tips from our pharmacists for people taking the medication
Somabaclofen
  • Take the medication at the same time each day.
  • Soma (carisoprodol) is not meant to be used long-term. It should be used for only 2 to 3 weeks maximum.
  • Can cause dizziness, fatigue, and sleepiness.
  • Don't drink alcohol while on this medication.
  • Soma (carisoprodol) can cause stomach pain, nausea and vomiting.
  • Lioresal (baclofen) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Don't stop taking Lioresal (baclofen) suddenly without talking to your doctor if you've been on it for a long time. It can be dangerous. Your doctor will help you get off it slowly over time.
  • Avoid drinking alcohol while on Lioresal (baclofen) because it can make you very sleepy or slow your breathing down.
Learn more
More about SomaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Soma (carisoprodol)?
Worth itNot sureNot worth it
More about baclofenSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lioresal (baclofen)?
Worth itNot sureNot worth it