Compare Sonata vs. Doxepin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Sonata
(zaleplon)

Zonalon
(doxepin)

Helps you sleep. Sonata (Zaleplon) helps you fall asleep, but it's not as good for staying asleep. It also interacts with a lot of diseases and other drugs.Helps you stop itching. Zonalon (Doxepin) works well treating itchy skin, but could make you sleepy.
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Coupons for Sonata
Best available price for 30 (10mg) capsules of sonata
Coupons for Doxepin
Best available price for 30 (10mg) capsules of doxepin
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
3.79Sonata
Reviews for Sonata
42%
of people (All ages) say Sonata is worth it
23%
say it works well
27%
say it's a big hassle
175 reviews
Have you used Sonata (zaleplon)?
Worth itNot sureNot worth it

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Have you used Zonalon (doxepin)?
Worth itNot sureNot worth it
Side effects
SonataDoxepin
  • Abdominal pain 3%
  • Drowsiness 1%
  • Eye pain 2%
  • Tingling sensation 2%
  • Menstrual cramps 1%
  • Amnesia 1%
More Sonata side effects »

We haven’t found good data for Doxepin side effects.

FDA side effect reports for Doxepin »
How it works
SonataDoxepin
Sonata (Zaleplon) is in a class of drugs called sedative-hypnotics. Researchers don't know exactly how it works, but it interacts with your brain to make you relaxed and sleepy.Zonalon (Doxepin) is an cream that stops you from itching by blocking the chemical receptors that cause itching.
Type of medication
SonataDoxepin
Prescription onlyPrescription only
Available as
SonataDoxepin
  • Pill
  • Cream, gel, or ointment
Used for
SonataDoxepin
  • Skin Intching Moderate
Risk factors for serious side effects
SonataDoxepin
  • Continuous use for 2 weeks or more
  • Alcohol
  • Taking other medicines that make you less alert
  • Less than 7 hours of sleep
  • Undiagnosed psychiatric conditions
Detailed Sonata (zaleplon) risks & warnings »
    Detailed Zonalon (doxepin) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Price
    SonataDoxepin
    No price related info.
    • It isn't available as a generic, so it could be kind of pricey.
    Interactions
    SonataDoxepin
    • Interacts badly with many other medications.
    • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
    Alcohol
    SonataDoxepin
    • It works best if taken without food and avoid taking it with alcohol or drugs.
    No alcohol related info.
    Kidneys and liver
    SonataDoxepin
    • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
    No kidneys and liver related info.
    Sleep
    SonataDoxepin
    • Only take it if you have time to sleep for at least 7 hours.
    • Can cause headache, drowsiness, or dizziness.
    • Effective at helping people fall asleep faster.
    • People have sleep-walked, sleep-driven, and sleep-eaten while on Sonata (Zaleplon).
    • Zonalon (Doxepin) can make you sleepy.
    Upsides and benefits
    SonataDoxepin
    • Effective at helping people fall asleep faster.
    • Doesn't last as long in the body as some other sleep medicines, so it's okay to take it in the middle of the night as long as you enough time to sleep. (But be sure to discuss it with your doctor first.)
    • In clinical trials, Zonalon (Doxepin) was found to be the most effective cream for treating itchy skin.
    • You can use Zonalon (Doxepin) for up to 8 days at a time.
    Downsides and risks
    SonataDoxepin
    • Not typically used for long-term treatment since it can be habit-forming.
    • Doesn't last as long in the body as other sleep medicines, so it's not as good at helping you stay asleep.
    • Interacts badly with many other medications.
    • Not a good option if you're pregnant or breast-feeding.
    • People have sleep-walked, sleep-driven, and sleep-eaten while on Sonata (Zaleplon).
    • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
    • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behaviors so you can sleep better naturally.
    • You need a prescription for Zonalon (Doxepin).
    • It isn't available as a generic, so it could be kind of pricey.
    • Zonalon (Doxepin) can make you sleepy.
    • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
    Tips from our pharmacists for people taking the medication
    SonataDoxepin
    • Take 30 to 45 minutes before bedtime.
    • Only take it if you have time to sleep for at least 7 hours.
    • It's very addictive and meant for short-term treatment. Dependence can start to form after using it daily for 2 weeks.
    • Can cause headache, drowsiness, or dizziness.
    • It works best if taken without food and avoid taking it with alcohol or drugs.
    • Withdrawal symptoms usually get better in 1 to 2 days.
    • Tell your doctor about any sudden confusion or changes in thoughts or behavior.
    • Be sure the affected area is clean and dry before applying Zonalon (Doxepin).
    • Wash your hands before and after using it.
    • Apply a thin layer of Zonalon (Doxepin) onto the affected area and rub it in gently.
    • Don’t put a bandage, dressing, or make-up over Zonalon (Doxepin) once it's on your skin.
    • It shouldn't affect you too much, but avoid activities that need you to be fully alert (like driving) until you know how it works.
    Learn more
    More about SonataSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Sonata (zaleplon)?
    Worth itNot sureNot worth it
    More about DoxepinSide effectsFDA package insert
    Have you used Zonalon (doxepin)?
    Worth itNot sureNot worth it