Compare Sonata vs. Hetlioz

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Sonata
(zaleplon)

Hetlioz
(tasimelteon)

Helps you sleep. Sonata (Zaleplon) helps you fall asleep, but it's not as good for staying asleep. It also interacts with a lot of diseases and other drugs.Keeps the sleep cycle normal for completely blind people who aren't able to see light. Hetlioz (tasimelteon) is the only approved medicine to help completely blind people who are unable to see light maintain regular sleep cycles. It is only available as a brand name, so it can be expensive.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
3.79Sonata
Reviews for Sonata
42%
of people (All ages) say Sonata is worth it
23%
say it works well
27%
say it's a big hassle
175 reviews
Have you used Sonata (zaleplon)?
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Have you used Hetlioz (tasimelteon)?
Worth itNot sureNot worth it
Side effects
SonataHetlioz
  • Abdominal pain 3%
  • Drowsiness 1%
  • Eye pain 2%
  • Tingling sensation 2%
  • Menstrual cramps 1%
  • Amnesia 1%
More Sonata side effects »
  • Headache 10%
  • Abnormal liver tests 5%
  • Nightmares or abnormal dreams 10%
  • Common cold or flu 7%
  • Urinary tract infection 5%
More Hetlioz side effects »
How it works
SonataHetlioz
Sonata (Zaleplon) is in a class of drugs called sedative-hypnotics. Researchers don't know exactly how it works, but it interacts with your brain to make you relaxed and sleepy.Hetlioz (tasimelteon) is a melatonin receptor agonist. It helps you to sleep at night and stay awake during the day.
Type of medication
SonataHetlioz
Prescription onlyPrescription only
Available as
SonataHetlioz
  • Pill
  • Pill
Used for
SonataHetlioz
  • Non 24 Hour Sleep Wake Cycle
Risk factors for serious side effects
SonataHetlioz
  • Continuous use for 2 weeks or more
  • Alcohol
  • Taking other medicines that make you less alert
  • Less than 7 hours of sleep
  • Undiagnosed psychiatric conditions
Detailed Sonata (zaleplon) risks & warnings »
    Detailed Hetlioz (tasimelteon) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Interactions
    SonataHetlioz
    • Interacts badly with many other medications.
    No interactions related info.
    Alcohol
    SonataHetlioz
    • It works best if taken without food and avoid taking it with alcohol or drugs.
    No alcohol related info.
    Kidneys and liver
    SonataHetlioz
    • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
    No kidneys and liver related info.
    Sleep
    SonataHetlioz
    • Only take it if you have time to sleep for at least 7 hours.
    • Can cause headache, drowsiness, or dizziness.
    • Effective at helping people fall asleep faster.
    • People have sleep-walked, sleep-driven, and sleep-eaten while on Sonata (Zaleplon).
    • If you go to sleep at a different time, don't take Hetlioz (tasimelteon).
    Upsides and benefits
    SonataHetlioz
    • Effective at helping people fall asleep faster.
    • Doesn't last as long in the body as some other sleep medicines, so it's okay to take it in the middle of the night as long as you enough time to sleep. (But be sure to discuss it with your doctor first.)
    • Hetlioz (tasimelteon) is not addictive.
    • Hetlioz (tasimelteon) is the only drug that's approved to help people unable to see light to have regular sleep cycles.
    • If you have to stop taking Hetlioz (tasimelteon) suddenly, you're not likely to have withdrawal.
    Downsides and risks
    SonataHetlioz
    • Not typically used for long-term treatment since it can be habit-forming.
    • Doesn't last as long in the body as other sleep medicines, so it's not as good at helping you stay asleep.
    • Interacts badly with many other medications.
    • Not a good option if you're pregnant or breast-feeding.
    • People have sleep-walked, sleep-driven, and sleep-eaten while on Sonata (Zaleplon).
    • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
    • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behaviors so you can sleep better naturally.
    • Hetlioz (tasimelteon) can take weeks to months for you to notice any effect.
    • Hetlioz (tasimelteon) is only available as a brand name so it can be expensive.
    Tips from our pharmacists for people taking the medication
    SonataHetlioz
    • Take 30 to 45 minutes before bedtime.
    • Only take it if you have time to sleep for at least 7 hours.
    • It's very addictive and meant for short-term treatment. Dependence can start to form after using it daily for 2 weeks.
    • Can cause headache, drowsiness, or dizziness.
    • It works best if taken without food and avoid taking it with alcohol or drugs.
    • Withdrawal symptoms usually get better in 1 to 2 days.
    • Tell your doctor about any sudden confusion or changes in thoughts or behavior.
    • Take Hetlioz (tasimelteon) at the same time every night.
    • Take Hetlioz (tasimelteon) on an empty stomach. Swallow capsule whole. Don't crush or chew the capsule.
    • If you go to sleep at a different time, don't take Hetlioz (tasimelteon).
    • Hetlioz (tasimelteon) might take weeks or months before you notice any effects.
    • If you smoke tobacco, Hetlioz (tasimelteon) might not work as well.
    Learn more
    More about SonataSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Sonata (zaleplon)?
    Worth itNot sureNot worth it
    More about HetliozSide effectsFDA package insert
    Have you used Hetlioz (tasimelteon)?
    Worth itNot sureNot worth it