Compare Sonata vs. Lunesta

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Sonata
(Zaleplon)

Lunesta
(Eszopiclone)

Helps you sleep. Sonata (Zaleplon) helps you fall asleep, but it's not as good for staying asleep. It also interacts with a lot of diseases and other drugs.Helps you sleep. Lunesta (Eszopiclone) is good for falling asleep and staying asleep. Not as habit-forming as some sleep medicines, but more likely to cause withdrawal symptoms if you stop suddenly.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
3.79Sonata
Reviews for Sonata (Zaleplon)
42%
of people (All ages) say Sonata (Zaleplon) is worth it
23%
say it works well
27%
say it's a big hassle
175 reviews
Have you used Sonata (Zaleplon)?
Worth itNot sureNot worth it
Reviews for Lunesta (Eszopiclone)
55%
+13% better vs. Sonata (Zaleplon)
36%
+13% better vs. Sonata (Zaleplon)
17%
+10% better vs. Sonata (Zaleplon)
592 reviews
Have you used Lunesta (Eszopiclone)?
Worth itNot sureNot worth it
Side effects
SonataLunesta
  • Abdominal pain 3%
  • Drowsiness 1%
  • Eye pain 2%
  • Tingling sensation 2%
  • Menstrual cramps 1%
  • Amnesia 1%
More Sonata side effects »
  • Headache 8%
  • Unpleasant taste 14%
  • Drowsiness 7%
  • Dizziness 1%
  • Nausea 1%
  • Infection 2%
  • Dry mouth 2%
  • Nervousness 2%
  • Low mood disorder 4%
More Lunesta side effects »
How it works
SonataLunesta
Sonata (Zaleplon) is in a class of drugs called sedative-hypnotics. Researchers don't know exactly how it works, but it interacts with your brain to make you relaxed and sleepy.Lunesta (Eszopiclone) is in a class of drugs called sedative-hypnotics. Researchers don't know exactly how it works, but it interacts with your brain to make you relaxed and sleepy.
Type of medication
SonataLunesta
Prescription only
Prescription only
Available as
SonataLunesta
  • Pill
  • Pill
Used for
SonataLunesta
Risk factors for serious side effects
SonataLunesta
  • Continuous use for 2 weeks or more
  • Alcohol
  • Taking other medicines that make you less alert
  • Less than 7 hours of sleep
  • Undiagnosed psychiatric conditions
  • Taking with alcohol or drugs
    • Women of childbearing age
    • Breast-feeding
    Detailed Sonata (Zaleplon) risks & warnings »
    • Continuous use for 2 weeks or more
    • Alcohol
    • Taking other medicines that make you less alert
    • Less than 7 hours of sleep.
    • Undiagnosed psychiatric conditions
    • Taking with alcohol or drugs that acts in the brain
      • Elderly
      • Higher dose
      • Liver problems
      • Taking Lunesta (Eszopiclone) with other nervous system depressants
      • Long-term use
      • Women of childbearing age
      • Breast-feeding
      Detailed Lunesta (Eszopiclone) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Interactions
      SonataLunesta
      • Interacts badly with many other medications.
      No interactions related info.
      Alcohol
      SonataLunesta
      • It works best if taken without food and avoid taking it with alcohol or drugs.
      • Might not be safe if you have a history of drug or alcohol abuse, depression, lung disease, or a condition that affects metabolism.
      • Avoid alcohol and drugs.
      Kidneys and liver
      SonataLunesta
      • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
      No kidneys and liver related info.
      Sleep
      SonataLunesta
      • Effective at helping people fall asleep faster.
      • People have sleep-walked, sleep-driven, and sleep-eaten while on Sonata (Zaleplon).
      • Only take it if you have time to sleep for at least 7 hours.
      • Can cause headache, drowsiness, or dizziness.
      • Effective at helping people fall asleep faster and sleep longer.
      • Only take it if you have time to sleep for at least 7 hours.
      • Can cause headache, drowsiness, and dizziness.
      • Lunesta (Eszopiclone) make you feel drowsy and sleepy, leading to falls and severe injuries. This is especially a risk if your older. Falls from sleep medicines like Lunesta (Eszopiclone) have caused severe injuries such as hip fractures and head injury. You may need a lower dose if you're taking other medicine that affects your nervous system or have issues with falls in the past. Check with your doctor first.
      Upsides and benefits
      SonataLunesta
      • Effective at helping people fall asleep faster.
      • Doesn't last as long in the body as some other sleep medicines, so it's okay to take it in the middle of the night as long as you enough time to sleep. (But be sure to discuss it with your doctor first.)
      • Effective at helping people fall asleep faster and sleep longer.
      • Not as habit-forming, so you can use it for longer than most other sleep medicines.
      Downsides and risks
      SonataLunesta
      • Not typically used for long-term treatment since it can be habit-forming.
      • Doesn't last as long in the body as other sleep medicines, so it's not as good at helping you stay asleep.
      • Interacts badly with many other medications.
      • Not a good option if you're pregnant or breast-feeding.
      • People have sleep-walked, sleep-driven, and sleep-eaten while on Sonata (Zaleplon).
      • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
      • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behaviors so you can sleep better naturally.
      • More likely to cause withdrawal symptoms if you stop taking it suddenly.
      • Might not be safe if you have a history of drug or alcohol abuse, depression, lung disease, or a condition that affects metabolism.
      • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behavior so that you can sleep better naturally.
      Tips from our pharmacists for people taking the medication
      SonataLunesta
      • Take 30 to 45 minutes before bedtime.
      • Only take it if you have time to sleep for at least 7 hours.
      • It's very addictive and meant for short-term treatment. Dependence can start to form after using it daily for 2 weeks.
      • Can cause headache, drowsiness, or dizziness.
      • It works best if taken without food and avoid taking it with alcohol or drugs.
      • Withdrawal symptoms usually get better in 1 to 2 days.
      • Tell your doctor about any sudden confusion or changes in thoughts or behavior.
      • Take 30 to 45 minutes before bedtime.
      • Only take it if you have time to sleep for at least 7 hours.
      • Very addictive. Meant for short-term treatment. Dependence can form after daily use for 2 weeks.
      • Can cause headache, drowsiness, and dizziness.
      • Can cause sleep-walking, sleep-driving, and sleep-eating.
      • Works best if taken without food.
      • Avoid alcohol and drugs.
      • Withdrawal symptoms usually resolve in 1 to 2 nights.
      • Report any confusion or changes in thoughts or behavior.
      Learn more
      More about SonataSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Sonata (Zaleplon)?
      Worth itNot sureNot worth it
      More about LunestaSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Lunesta (Eszopiclone)?
      Worth itNot sureNot worth it