Compare Sonata vs. Remeron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Sonata
(Zaleplon)

Remeron
(Mirtazapine)

Helps you sleep. Sonata (Zaleplon) helps you fall asleep, but it's not as good for staying asleep. It also interacts with a lot of diseases and other drugs.Improves mood. Remeron (Mirtazapine) is okay for treating depression and good for sleep. More likely to cause weight gain than any other antidepressant.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
3.810344827586207Sonata
Reviews for Sonata (Zaleplon)
42%
of people say Sonata (Zaleplon) is worth it
24%
say it works well
27%
say it's a big hassle
Reviews for Remeron (Mirtazapine)
47%
+5% vs. Sonata (Zaleplon)
42%
+18% vs. Sonata (Zaleplon)
26%
+1% vs. Sonata (Zaleplon)
Side effects
SonataRemeron
  • Headache 7%
  • Abdominal pain 3%
  • Amnesia 3%
  • Muscle weakness 2%
  • Eye pain 2%
  • Menstrual cramps 2%
  • Drowsiness 2%
  • Tingling sensation 2%
  • Dizziness 2%
  • Tremor 1%
More Sonata side effects »
  • Drowsiness 36%
  • Increased appetite 15%
  • Dry mouth 10%
  • Weight gain 10%
  • Constipation 6%
  • Dizziness 4%
  • Muscle weakness 3%
  • Abnormal dreams 3%
  • Flu syndrome 2%
  • Thinking abnormal 2%
More Remeron side effects »
How it works
SonataRemeron
Sonata (Zaleplon) is in a class of drugs called sedative-hypnotics. Researchers don't know exactly how it works, but it interacts with your brain to make you relaxed and sleepy.Remeron (Mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.
Type of medication
SonataRemeron
SedativePrescription only
Antidepressant
Noradrenergic and specific serotonergic antidepressant
Prescription only
Available as
SonataRemeron
  • Pill
  • Pill
  • Dissolving tablet
Used for (click to learn more)
SonataRemeron
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Sonata (Zaleplon)

After 4 weeks using Start and Remeron (Mirtazapine), here’s how much better people feel.

Risk factors for serious side effects
SonataRemeron
  • Continuous use for 2 weeks or more
  • Alcohol
  • Taking other medicines that make you less alert
  • Less than 7 hours of sleep
  • Undiagnosed psychiatric conditions
  • Taking with alcohol or drugs
    • Women of childbearing age
    • Breast-feeding
    Detailed Sonata (Zaleplon) risks & warnings »
    • Age 24 years or younger
    • Using other medications that affect serotonin
    • History of heart problems
    • History of liver problems
    • Higher dose
    • Alcohol
    • Taking other medicines that make you less alert
        Detailed Remeron (Mirtazapine) risks & warnings »
        Pregnancy category
        SonataRemeron
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        Alcohol
        • It works best if taken without food and avoid taking it with alcohol or drugs.
        • Sonata (Zaleplon) can be disinhibiting (like alcohol) or cause hallucinations. Tell your doctor if you notice any unusual changes in behavior.
        No specific alcohol-related info.
        Food
        • It works best if taken without food and avoid taking it with alcohol or drugs.
        No specific food-related info.
        Kidneys and liver
        • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
        No specific kidneys and liver-related info.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        • Doesn't last as long in the body as other sleep medicines, so it's not as good at helping you stay asleep.
        • People have sleep-walked, sleep-driven, and sleep-eaten while on Sonata (Zaleplon).
        • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behaviors so you can sleep better naturally.
        • Doesn't last as long in the body as some other sleep medicines, so it's okay to take it in the middle of the night as long as you enough time to sleep. (But be sure to discuss it with your doctor first.)
        • Only take it if you have time to sleep for at least 7 hours.
        • Can cause headache, drowsiness, or dizziness.
        • All prescription sleep-aid medicines like Sonata (Zaleplon) have a risk of physical dependence. Dependence means that you'll feel withdrawal symptoms if you stop taking the medication all at once. Talk to your doctor about natural ways to improve sleep or treat underlying conditions that prevent sleep.
        • Sonata (Zaleplon) increases your risk of performing potentially dangerous activities while asleep, such as sleep-walking, sleep-driving, and sleep-eating. Talk to your doctor immediately about stopping Sonata (Zaleplon) if any sleep-related activities occur.
        No specific sleep-related info.
        Weight
        No specific weight-related info.
        • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
        • Good option for people who are underweight or frail, because it can help you gain weight.
        • Can increase appetite and weight.
        • Remeron (Mirtazapine) can increase appetite and cause you to gain weight.
        Upsides and benefits
        SonataRemeron
        • Effective at helping people fall asleep faster.
        • Doesn't last as long in the body as some other sleep medicines, so it's okay to take it in the middle of the night as long as you enough time to sleep. (But be sure to discuss it with your doctor first.)
        • Effective at relieving some depression symptoms.
        • Starts to work more quickly than most antidepressants.
        • Might be a good option for people who have insomnia with their depression, because it can make you very sleepy.
        • Good option for people who are underweight or frail, because it can help you gain weight.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        Downsides and risks
        SonataRemeron
        • Not typically used for long-term treatment since it can be habit-forming.
        • Doesn't last as long in the body as other sleep medicines, so it's not as good at helping you stay asleep.
        • Interacts badly with many other medications.
        • Not a good option if you're pregnant or breast-feeding.
        • People have sleep-walked, sleep-driven, and sleep-eaten while on Sonata (Zaleplon).
        • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
        • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behaviors so you can sleep better naturally.
        • Not as effective as other medications for depression.
        • More sedating than other antidepressants.
        • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
        • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        Tips from our pharmacists for people taking the medication
        SonataRemeron
        • Take 30 to 45 minutes before bedtime.
        • Only take it if you have time to sleep for at least 7 hours.
        • It's very addictive and meant for short-term treatment. Dependence can start to form after using it daily for 2 weeks.
        • Can cause headache, drowsiness, or dizziness.
        • It works best if taken without food and avoid taking it with alcohol or drugs.
        • Withdrawal symptoms usually get better in 1 to 2 days.
        • Tell your doctor about any sudden confusion or changes in thoughts or behavior.
        • Makes you sleepy. Take at bedtime.
        • Can increase appetite and weight.
        • Takes 8 to 12 weeks to see full effects on mood.
        • Stop taking slowly to avoid withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        Learn more
        More about SonataSide effectsReviews & ratingsAlternativesFDA package insert
        More about RemeronSide effectsReviews & ratingsAlternativesFDA package insert