Compare Sonata vs. Remeron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Sonata
(zaleplon)

Remeron
(mirtazapine)

Helps you sleep. Sonata (Zaleplon) helps you fall asleep, but it's not as good for staying asleep. It also interacts with a lot of diseases and other drugs.Improves mood. Remeron (Mirtazapine) is okay for treating depression and good for sleep. More likely to cause weight gain than any other antidepressant.
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Prices and coupon for 30 (10mg) capsules of zaleplon
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Prices and coupon for 30 (15mg) tablets of mirtazapine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
3.79Sonata
Reviews for Sonata (zaleplon)
42%
of people (All ages) say Sonata (zaleplon) is worth it
23%
say it works well
27%
say it's a big hassle
175 reviews
Have you used Sonata (zaleplon)?
Worth itNot sureNot worth it
Reviews for Remeron (mirtazapine)
45%
+3% better vs. Sonata (zaleplon)
39%
+16% better vs. Sonata (zaleplon)
26%
+1% better vs. Sonata (zaleplon)
152 reviews
Have you used Remeron (mirtazapine)?
Worth itNot sureNot worth it
Side effects
SonataRemeron
  • Abdominal pain 3%
  • Drowsiness 1%
  • Eye pain 2%
  • Tingling sensation 2%
  • Menstrual cramps 1%
  • Amnesia 1%
More Sonata side effects »
  • Drowsiness 36%
  • Dry mouth 10%
  • Increased appetite 15%
  • Constipation 6%
  • Weight gain 10%
  • Muscle weakness 3%
  • Dizziness 4%
  • Flu syndrome 2%
  • Abnormal dreams 3%
  • Thinking abnormal 2%
More Remeron side effects »
How it works
SonataRemeron
Sonata (Zaleplon) is in a class of drugs called sedative-hypnotics. Researchers don't know exactly how it works, but it interacts with your brain to make you relaxed and sleepy.Remeron (Mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.
Type of medication
SonataRemeron
Prescription only
Prescription only
Available as
SonataRemeron
  • Pill
  • Pill
  • Dissolving tablet
Used for
SonataRemeron
Risk factors for serious side effects
SonataRemeron
  • Continuous use for 2 weeks or more
  • Alcohol
  • Taking other medicines that make you less alert
  • Less than 7 hours of sleep
  • Undiagnosed psychiatric conditions
  • Taking with alcohol or drugs
    • Women of childbearing age
    • Breast-feeding
    Detailed Sonata (zaleplon) risks & warnings »
    • Age 24 years or younger
    • Using other medications that affect serotonin
    • History of heart problems
    • History of liver problems
    • Higher dose
    • Alcohol
    • Taking other medicines that make you less alert
        Detailed Remeron (mirtazapine) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Interactions
        SonataRemeron
        • Interacts badly with many other medications.
        No interactions related info.
        Alcohol
        SonataRemeron
        • It works best if taken without food and avoid taking it with alcohol or drugs.
        No alcohol related info.
        Kidneys and liver
        SonataRemeron
        • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
        No kidneys and liver related info.
        Sleep
        SonataRemeron
        • Effective at helping people fall asleep faster.
        • People have sleep-walked, sleep-driven, and sleep-eaten while on Sonata (Zaleplon).
        • Only take it if you have time to sleep for at least 7 hours.
        • Can cause headache, drowsiness, or dizziness.
        No sleep related info.
        Weight
        SonataRemeron
        No weight related info.
        • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
        • Can increase appetite and weight.
        • Remeron (Mirtazapine) can increase appetite and cause you to gain weight.
        Upsides and benefits
        SonataRemeron
        • Effective at helping people fall asleep faster.
        • Doesn't last as long in the body as some other sleep medicines, so it's okay to take it in the middle of the night as long as you enough time to sleep. (But be sure to discuss it with your doctor first.)
        • Effective at relieving some depression symptoms.
        • Starts to work more quickly than most antidepressants.
        • Might be a good option for people who have insomnia with their depression, because it can make you very sleepy.
        • Good option for people who are underweight or frail, because it can help you gain weight.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        Downsides and risks
        SonataRemeron
        • Not typically used for long-term treatment since it can be habit-forming.
        • Doesn't last as long in the body as other sleep medicines, so it's not as good at helping you stay asleep.
        • Interacts badly with many other medications.
        • Not a good option if you're pregnant or breast-feeding.
        • People have sleep-walked, sleep-driven, and sleep-eaten while on Sonata (Zaleplon).
        • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
        • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behaviors so you can sleep better naturally.
        • Not as effective as other medications for depression.
        • More sedating than other antidepressants.
        • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
        • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        Tips from our pharmacists for people taking the medication
        SonataRemeron
        • Take 30 to 45 minutes before bedtime.
        • Only take it if you have time to sleep for at least 7 hours.
        • It's very addictive and meant for short-term treatment. Dependence can start to form after using it daily for 2 weeks.
        • Can cause headache, drowsiness, or dizziness.
        • It works best if taken without food and avoid taking it with alcohol or drugs.
        • Withdrawal symptoms usually get better in 1 to 2 days.
        • Tell your doctor about any sudden confusion or changes in thoughts or behavior.
        • Makes you sleepy. Take at bedtime.
        • Can increase appetite and weight.
        • Takes 8 to 12 weeks to see full effects on mood.
        • Stop taking slowly to avoid withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        Learn more
        More about SonataSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Sonata (zaleplon)?
        Worth itNot sureNot worth it
        More about RemeronSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Remeron (mirtazapine)?
        Worth itNot sureNot worth it