Compare Sonata vs. Rozerem

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Sonata
(zaleplon)

Rozerem
(ramelteon)

Helps you sleep. Sonata (Zaleplon) helps you fall asleep, but it's not as good for staying asleep. It also interacts with a lot of diseases and other drugs.Helps you fall asleep. Rozerem (ramelteon) is a good sleep medicine that's not addictive, but it can be expensive.
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Coupons for Sonata
Best available price for 30 (10mg) capsules of zaleplon
Coupons for Rozerem
Best available price for 30 (8mg) tablets of ramelteon
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
3.79Sonata
Reviews for Sonata (zaleplon)
42%
of people (All ages) say Sonata (zaleplon) is worth it
23%
say it works well
27%
say it's a big hassle
175 reviews
Have you used Sonata (zaleplon)?
Worth itNot sureNot worth it
Reviews for Rozerem (ramelteon)
Not enough review data. Review it!
-42% worse vs. Sonata (zaleplon)
Not enough review data. Review it!
-23% worse vs. Sonata (zaleplon)
Not enough review data. Review it!
+27% better vs. Sonata (zaleplon)
Have you used Rozerem (ramelteon)?
Worth itNot sureNot worth it
Side effects
SonataRozerem
  • Abdominal pain 3%
  • Drowsiness 1%
  • Eye pain 2%
  • Tingling sensation 2%
  • Menstrual cramps 1%
  • Amnesia 1%
More Sonata side effects »
  • Dizziness 1%
  • Sleepiness 1%
  • Fatigue 1%
  • Nausea 1%
  • Worsening insomnia 1%
More Rozerem side effects »
How it works
SonataRozerem
Sonata (Zaleplon) is in a class of drugs called sedative-hypnotics. Researchers don't know exactly how it works, but it interacts with your brain to make you relaxed and sleepy.Rozerem (ramelteon) is a melatonin receptor agonist. Melatonin is a chemical the body uses to maintain a normal sleeping cycle; Rozerem (ramelteon) helps you fall asleep and stay asleep.
Type of medication
SonataRozerem
Prescription only
Prescription only
Available as
SonataRozerem
  • Pill
  • Pill
Used for
SonataRozerem
Risk factors for serious side effects
SonataRozerem
  • Continuous use for 2 weeks or more
  • Alcohol
  • Taking other medicines that make you less alert
  • Less than 7 hours of sleep
  • Undiagnosed psychiatric conditions
Detailed Sonata (zaleplon) risks & warnings »
  • Alcohol
  • Taking narcotics, tranquilizers, or antihistamines
Detailed Rozerem (ramelteon) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
SonataRozerem
  • Interacts badly with many other medications.
No interactions related info.
Alcohol
SonataRozerem
  • It works best if taken without food and avoid taking it with alcohol or drugs.
  • While taking Rozerem (ramelteon), don't drink alcohol or take other medicines that can make you sleepy, like opioids for pain relief, or benzodiazepines for anxiety.
Kidneys and liver
SonataRozerem
  • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
No kidneys and liver related info.
Pain
SonataRozerem
No pain related info.
  • If you’re taking Rozerem (ramelteon), you need to be very careful about drinking alcohol, or taking medicines such as narcotics for pain relief, tranquilizers for anxiety, or antihistamines. Taking Rozerem (ramelteon) with alcohol or these medicines can slow down your central nervous system to the point where you stop breathing. Talk to your doctor to see if you should change your other medicines while you take Rozerem (ramelteon).
Sleep
SonataRozerem
  • Effective at helping people fall asleep faster.
  • People have sleep-walked, sleep-driven, and sleep-eaten while on Sonata (Zaleplon).
  • Only take it if you have time to sleep for at least 7 hours.
  • Can cause headache, drowsiness, or dizziness.
  • Don't take Rozerem (ramelteon) if you're not able to sleep for at least 8 hours.
  • If you're not sleeping better after taking Rozerem (ramelteon) for 7 to 10 days, talk to your doctor.
Upsides and benefits
SonataRozerem
  • Effective at helping people fall asleep faster.
  • Doesn't last as long in the body as some other sleep medicines, so it's okay to take it in the middle of the night as long as you enough time to sleep. (But be sure to discuss it with your doctor first.)
  • Rozerem (ramelteon) isn't a controlled medicine, and it's safe to use in people age 65 or older.
  • If you stop taking Rozerem (ramelteon) suddenly, your insomnia won't come back.
  • Rozerem (ramelteon) won't make you feel hungover or groggy the next day.
Downsides and risks
SonataRozerem
  • Not typically used for long-term treatment since it can be habit-forming.
  • Doesn't last as long in the body as other sleep medicines, so it's not as good at helping you stay asleep.
  • Interacts badly with many other medications.
  • Not a good option if you're pregnant or breast-feeding.
  • People have sleep-walked, sleep-driven, and sleep-eaten while on Sonata (Zaleplon).
  • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
  • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behaviors so you can sleep better naturally.
  • Rozerem (ramelteon) is only available as a brand name.
  • Rozerem (ramelteon) is only available in 1 strength.
  • If you take Rozerem (ramelteon) on a full stomach, it won't work as well.
  • Not recommended for children.
  • Rozerem (ramelteon) can't be used if you have sleep apnea.
Tips from our pharmacists for people taking the medication
SonataRozerem
  • Take 30 to 45 minutes before bedtime.
  • Only take it if you have time to sleep for at least 7 hours.
  • It's very addictive and meant for short-term treatment. Dependence can start to form after using it daily for 2 weeks.
  • Can cause headache, drowsiness, or dizziness.
  • It works best if taken without food and avoid taking it with alcohol or drugs.
  • Withdrawal symptoms usually get better in 1 to 2 days.
  • Tell your doctor about any sudden confusion or changes in thoughts or behavior.
  • Take Rozerem (ramelteon) on an empty stomach 30 minutes before you sleep.
  • Don't take Rozerem (ramelteon) if you're not able to sleep for at least 8 hours.
  • Swallow the Rozerem (ramelteon) tablet whole; don't break or crush it.
  • While taking Rozerem (ramelteon), don't drink alcohol or take other medicines that can make you sleepy, like opioids for pain relief, or benzodiazepines for anxiety.
  • If you're not sleeping better after taking Rozerem (ramelteon) for 7 to 10 days, talk to your doctor.
Learn more
More about SonataSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Sonata (zaleplon)?
Worth itNot sureNot worth it
More about RozeremSide effectsAlternativesFDA package insert
Have you used Rozerem (ramelteon)?
Worth itNot sureNot worth it