Compare Spiriva vs. Dulera

Head-to-head comparisons of medication uses, side effects, ratings, and more.


(Mometasone / Formoterol)

Makes it easier to breathe. Spiriva (Tiotropium) works well to reduce COPD symptoms and flare-ups with fewer side effects than some medicines that open airways, but you have to use it every day.Prevents breathing problems. Dulera (Mometasone / Formoterol) is a convenient medication that'll control your asthma long-term, but it won’t stop a sudden asthma attack.
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Reviews & ratings
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Reviews for Spiriva (Tiotropium)
of people (All ages) say Spiriva (Tiotropium) is worth it
say it works well
say it's a big hassle
Have you used Spiriva (Tiotropium)?
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Have you used Dulera (Mometasone / Formoterol)?
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Side effects
  • Dry mouth 13%
  • Respiratory tract infection 4%
  • Sore throat 2%
  • Sinus inflammation 2%
  • Urinary tract infection 2%
  • Chest pain (non-specific) 2%
  • Abdominal pain 2%
  • Yeast infection 2%
  • Rash 2%
  • Nosebleed 2%
More Spiriva side effects »
  • Sinus inflammation 2%
  • Common cold 1%
  • Headache 1%
More Dulera side effects »
How it works
Spiriva (Tiotropium) is a bronchodilator. It relaxes muscles in your lungs to open your airways and make breathing easier.Dulera (Mometasone / Formoterol) is a combination asthma medicine. Mometasone (a corticosteroid) lowers lung inflammation and works to control your asthma and prevent asthma attacks. Formoterol (a long-acting bronchodilator) relaxes muscles in your lungs to open airways and prevent wheezing and shortness of breath.
Type of medication
Long-acting bronchodilator
Prescription only
Long-acting bronchodilator
Beta-2 agonist
Prescription only
Available as
  • Inhaler
  • Inhaler
Used for (click to learn more)
Risk factors for serious side effects
  • History of atropine allergic reaction
    • History of narrow-angle glaucoma
    • History of urinary bladder blockage (urinary obstruction)
    • History of enlarged prostate
    • Severe milk protein allergy
    • History of moderate to severe kidney disease
    • Taking with other anticholinergic medications
    Detailed Spiriva (Tiotropium) risks & warnings »
    • Adverse effect of all long-acting beta agonist drugs (LABAs)
    • Lowering dose or stopping Dulera (Mometasone / Formoterol) too quickly, especially after long-term treatment
    • Stress such as trauma, surgery, or infection
    • Long-term inactivity
    • History or family history of osteoporosis (postmenopausal bone loss)
    • Long-term use of drugs that cause bone loss
    • History of heart rhythm problems
    • High blood pressure
    • Heart failure
    • Long-term treatment with Dulera (Mometasone / Formoterol)
    • Not vaccinated against chickenpox or measles
    • Age greater than 65 years
    • Dose of Dulera (Mometasone / Formoterol)
    • Duration of treatment
    • History of high internal eye pressure
    • History of cataracts
    • History of glaucoma
    Detailed Dulera (Mometasone / Formoterol) risks & warnings »

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Kidneys and liver
    • The kidney is mainly responsible for removing Spiriva (Tiotropium) from the body so people with kidney disease or reduced function need to be watched closely. Spiriva (Tiotropium) can build up in the body and cause certain side effects. Tell your doctor if you develop dry mouth, blurry vision, confusion, sweating, increased heart rate or constipation. You may need to discuss other medication options to treat your COPD.
    • Adrenal suppression can occur if you lower your dose or stop taking Dulera (Mometasone / Formoterol) too quickly. Symptoms include joint or muscle pain, extreme low energy, and depression. Changes in your medication need to be done slowly and over time. Talk to your doctor before you decrease or stop Dulera (Mometasone / Formoterol).
    Upsides and benefits
    • Helps you breathe easier and lessens the need for a fast-acting (rescue) inhaler.
    • Reduces flare-ups and hospitalizations with fewer side effects compared to some other medicines that open airways.
    • You only need to take it once a day.
    • It's a combination medicine that lowers inflammation and opens airways in your lungs.
    • Significantly improves lung function and lowers the number of flare-ups by 70%. Also reduces rescue inhaler use in asthma.
    • By inhaling this medication, it gets into your lungs quickly and doesn't affect the rest of your body as much, so if should have a lower risk of side effects.
    • Some people who take Dulera (Mometasone / Formoterol) are able to use their fast-acting rescue inhalers less often.
    Downsides and risks
    • Won't cure your COPD (but it will relieve your symptoms).
    • You'll need to use this medicine for a long time, and you have to take it every day.
    • Can make symptoms of enlarged prostate or urinary blockage worse.
    • Can worsen a certain type of glaucoma.
    • You might feel dizzy or have blurry vision while taking this medicine.
    • You need to use Dulera (Mometasone / Formoterol) twice a day to control your symptoms.
    • It doesn’t stop a sudden asthma attack. You always need to have a rescue inhaler close by to treat sudden symptoms or breathing problems.
    • Steroids can suppress your immune system, so you can catch bacterial and viral infections easier while on this.
    • You may need to take a different medicine if your asthma doesn’t improve and you need your rescue inhaler more often, or if tests show that your lung function is reduced.
    Tips from our pharmacists for people taking the medication
    • Don't swallow the capsule. Insert the capsule into an inhaler device only.
    • Use daily to control your COPD.
    • Starts working the first few hours, but it may take longer to feel full effects.
    • Prevents breathing problems, but doesn't stop sudden cough or wheezing once they start.
    • Don't breathe out into the inhaler.
    • You might feel dizzy and notice changes in your vision.
    • Don't use it if you have an allergy to atropine.
    • Contains lactose, so don't use it if you're allergic to milk protein.
    • Starts working right away, but it can take 1 to 2 weeks to feel the full effects.
    • Inhale two separate puffs in the morning and two separate puffs in the evening. It’s important to read the information that comes with your medicine so you use it the correctly.
    • Clean the mouthpiece with a dry cloth every 7 days and don’t wash it with water.
    • Rinse your mouth out with water after each use to lower your chance of getting a yeast infection (thrush) in the mouth and throat.
    Learn more
    More about SpirivaSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Spiriva (Tiotropium)?
    Worth itNot sureNot worth it
    More about DuleraSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Dulera (Mometasone / Formoterol)?
    Worth itNot sureNot worth it